阿爾茨海默癥英語介紹市公開課金獎市賽課一等獎課件

1、Alzheimers Disease阿爾茨海默癥 第1頁Ronald Wilson Reagan羅納德威爾遜里根第40任（第49-50屆）美國總統(tǒng) president“I know Im on my way to the twilight. I know theres always a bright dawn ahead of the United states. Thank you, my friends. May God bless you forever.”第2頁brief introduction01PathogenyTreatment03Clinical manifestation0

2、2Other04Catalog第3頁brief introduction1第4頁What?Alzheimers disease (AD) is a progressive neurodegenerative disorder .臨床癥狀Clinical symptom記憶障礙dysmnesia失語aphasia失認agnosia執(zhí)行功效障礙executive dysfunction癡呆dementiaThe disease usually begins after age 60, and risk goes up with age.第5頁Two typesAlzheimers disease(

3、AD) 65 years oldsenile dementia(SDAT)65 years old第6頁NameIn 1906,AD is named by Dr. Alois Alzheimer, a German doctor. Dr. Alzheimer noticed changes in the brain tissue of a woman who had died of an unusual mental illness.He found abnormal clumps. Scientists also have found other brain changes in peop

4、le with AD.Nerve cells die in areas of the brain that are vital to memory and other mental abilities.第7頁Clinical manifestation2第8頁Clinical manifestation期期期death1-3 years2-10 years8-12 yearsMild dementiaModerate dementiaSevere dementiaMore women than men 7:54:6Disease for up to 10-20 years第9頁Degradat

5、ion of memory and cognitionWilliam Utermohlen自畫像第10頁Degradation of memory and cognitionWilliam Utermohlen is an American artist, in 1995 he was diagnosed with Alzheimers disease. Since then, he has decided to take advantage of the limited time available to retain memory and better understand himself

6、 through self portraits.William insisted the 5 New Year paintings self portrait, until completely forgotten how to draw. From the use of skilled drawing, dark portrayal of vivid features, to the same color, shape deformation, self portrait became more and more abstract (pictured above).第11頁Degradati

7、on of memory and cognition the effects of Alzheimers disease on the right parietal lobe of the brain are particularly severe, which directly affects the ability of the brain to visualize and develop the ability to draw pictures of the brain.said Dr. Bruce Miller, a neurologist.His work became more a

8、bstract, may be the parietal function damaged, causing blindness.What kind of changes have occurred in the brains of patients with dementia, which is not yet fully understood by the world s academia.第12頁PathogenyTreatment3第13頁Pathogenesis hypothesis of AD第14頁PathogenyAbnormal amyloid beta cell depos

9、ition in neuronsAbnormal phosphorylation of tau proteinvs第15頁Beta amyloid (blue curve) and Tau protein (orange curve) Research papers published in recent 30 years第16頁Treatmentincrease the concentration of acetylcholine (Ach) in the brainpromoting survival of cholinergic neurons in the brain or improving their nerve conduction functionreducing the production or promoting degradation of beta amyloid第17頁Other4第18頁Still AliceFilmThe film tells the story of Ali