Purvalanol-B-NG-95-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEPurvalanol BCat. No.: HY-18299CAS No.: 212844-54-7Synonyms: NG 95分式: CHClNO分量: 432.9作靶點(diǎn): CDK作通路: Cell Cycle/DNA Damage儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 40 mg/mL (92.40 mM)* me

2、ans soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.3100 mL 11.5500 mL 23.1000 mL5 mM 0.4620 mL 2.3100 mL 4.6200 mL10 mM 0.2310 mL 1.1550 mL 2.3100 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Purvalanol B(NG-95)是CDK抑制劑，對cdc2/cyclin B，cdk2

3、/cyclin A，cdk2/cyclin E，cdk4/cyclin D1和cdk5-p35的IC50 分別為6，6，9， 10000和6 nM。IC50 & Target cdc2/cyclin B cyclin dependent cdk2/cyclin A CDK2/cyclinE6 nM (IC50) kinase 1-cyclinB 6 nM (IC50) 9 nM (IC50)1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE6 nM (IC50)CDK5/p35 Cdk4/cyclin D1 TrkA TrkB6 nM (IC50

4、) 10000 nM (IC50) 51 nM (IC50) 11 nM (IC50)REFERENCES1. purvalanol B (CID 448991) - Compound BioActivity Data2. Knockaert M, et al. p42/p44 MAPKs are intracellular targets of the CDK inhibitor purvalanol. Oncogene. 2002 Sep 19;21(42):6413-24.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: 021