Costunolide-plus-Costunolide-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemECostunolideCat. No.: HY-N0036CAS No.: 553-21-9Synonyms: (+)-Costunolide; Costus lactone分式: CHO分量: 232.32作靶點(diǎn): Apoptosis作通路: Apoptosis儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 49 mg/mL

2、(210.92 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 4.3044 mL 21.5220 mL 43.0441 mL5 mM 0.8609 mL 4.3044 mL 8.6088 mL10 mM 0.4304 mL 2.1522 mL 4.3044 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前?qǐng)先配制澄清的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)

3、結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.58 mg/mL (11.11 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.58 mg/mL (11.11 mM); Clear solution1/2 Master of Small Mole

4、cules 您邊的抑制劑師www.MedChemE3. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.58 mg/mL (11.11 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Costunolide有抗炎和抗氧化活性，能介導(dǎo)凋亡。戶使本產(chǎn)品發(fā)表的科研獻(xiàn) Cell Mol Biol Lett. 2019 Aug 14;24:52. Gene. 2018 Dec 15;678:261-269.See more customer validations on HYPERLINK / www.MedChemEREF

5、ERENCES1. Cheon YH, Song MJ, Kim JY, Costunolide Inhibits Osteoclast Differentiation by Suppressing c-Fos Transcriptional Activity. PhytotherRes. 2013 Jul 6.2. Rasul A, Bao R, Malhi M, Induction of apoptosis by costunolide in bladder cancer cells is mediated through ROS generation andmitochondrial d

6、ysfunction. Molecules. 2013 Jan 24;18(2):1418-33.3. Kretschmer N, Rinner B, Stuendl N, Effect of costunolide and dehydrocostus lactone on cell cycle, apoptosis, and ABC transporterexpression in human soft tissue sarcoma cells. Planta Med. 2012 Nov;78(16):1749-56.4. Matsuda H, Shimoda H, Ninomiya K,

7、Inhibitory mechanism of costunolide, a sesquiterpene lactone isolated from Laurus nobilis, onblood-ethanol elevation in rats: involvement of inhibition of gastric emptying and increase in gastric juice secretion. Alcohol Alcohol. 2002Mar-Apr;37(2):121-7.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use