BTR-1 - Apoptosis Activator - 生命科學(xué)試劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEBTR-1Cat. No.: HY-111617CAS No.: 18331-34-5分式: CHNOS分量: 249.35作靶點(diǎn): Apoptosis作通路: Apoptosis儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 25 mg/mL (100.26 mM; Need ultrasonic)H2O : 40% PEG3

2、00 5% Tween-80 45% salineSolubility: 2.08 mg/mL (8.34 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (8.34 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 BTR-1種活性抗癌劑，能夠誘導(dǎo)細(xì)胞周 期 S 期停滯，影響 DNA 復(fù)制。BTR-1 可激活凋亡 (apoptosis)，導(dǎo)致細(xì)胞死亡 1。I

3、C50 & Target Apoptosis 1體外研究 BTR-1 (10, 50, 100, and 250 M, 5 days) dose-dependently causes cytotoxicity in human leukemic cells, withIC50s of 8 and 6 M at 48 and 72 h, respectively 1.Cell Viability Assay 1Cell Line: T-cell leukemic cell linesConcentration: 10, 50, 100, and 250 MIncubation Time: 5 d

4、aysResult: Induced cytotoxicity in human leukemic cells in a dose-dependent manner.REFERENCES1. Moorthy BT, et al. Novel rhodanine derivatives induce growth inhibition followed by apoptosis. Bioorg Med Chem Lett. 2010 Nov1;20(21):6297-301.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: 021