Photo-lysine-hydrochloride _Biochemical Assay Reagent - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEPhoto-lysine hydrochlorideCat. No.: HY-19804A分式: CHClNO分量: 245.11作靶點: Others作通路: Others儲存式: 4C, protect from light, stored under nitrogen* In solvent : -80C, 6 months; -20C, 1 month (protect fromlight, stored under nitrogen)溶解性數(shù)

2、據(jù)體外實驗 H2O : 40 mg/mL (163.19 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 4.0798 mL 20.3990 mL 40.7980 mL5 mM 0.8160 mL 4.0798 mL 8.1596 mL10 mM 0.4080 mL 2.0399 mL 4.0798 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Photo-lysi

3、ne hydrochloride，種新的于賴氨酸光反應性的氨 酸，它捕獲結(jié)合賴氨酸翻譯后修飾的蛋質(zhì)。體外研究Photo-lysine is designed and synthesized by incorporating a photo-cross-linker (diazirine) into the side chainof natural lysine. Photo-lysine, which is readily incorporated into proteins by native mammalian translationmachinery, can be used to ca

4、pture and identify proteins that recognize lysine post-translational modifications(PTMs), including readers and erasers of histone modifications. Photo-lysine can be incorporated intoMDH2 and mediate photo-cross-linking to fix protein-protein interactions in cells. UV irradiation of cells in thepres

5、ence of photo-lysine induced robust cross-linking of HSP90 and HSP60. Photo-lysine has higher1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEefficiency than photo-leucine for photo-cross-linking of the two chaperone proteins. Photo-lysine enablescapture of the heterodimer of proteins Ku70 and Ku80

6、within a protein complex. Photo-lysine enablesidentification of histone- and chromatin-binding proteins 1.REFERENCES1. Yang T, et al. Photo-lysine captures proteins that bind lysine post-translational modifications. Nat Chem Biol. 2016 Feb;12(2):70-2.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-