DUBs-IN-1 _Deubiquitinase 抑制劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEDUBs-IN-1Cat. No.: HY-50736CAS No.: 924296-18-4分式: CHNO分量: 337.33作靶點(diǎn): Deubiquitinase作通路: Cell Cycle/DNA Damage儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 20 mg/mL (59.29 mM; Need ultras

2、onic and warming)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 2.9645 mL 14.8223 mL 29.6446 mL5 mM 0.5929 mL 2.9645 mL 5.9289 mL10 mM 0.2964 mL 1.4822 mL 2.9645 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 DUBs-IN-1種有活性的泛素特異性蛋酶 (ubiquitin-specific proteases) 抑制劑，對(duì) USP8 的

3、 IC50 值為0.24 M。IC50 & Target IC50: 0.24 M (USP8) 1體外研究DUBs-IN-1 (22 f) is an active inhibitor of ubiquitin-specific proteases, with an IC50 of 0.24 M for USP8.DUBs-IN-1 is inactive toward USP7 (IC50, 100 M). DUBs-IN-1 and its analogs reduce the viability of1/2 Master of Small Molecules 您邊的抑制劑師www.Me

4、dChemEHCT116 colon and PC-3 prostate cancer cell lines with IC50s ranging from 0.5 M to 1.5 M 1.戶使本產(chǎn)品發(fā)表的科研獻(xiàn) Harvard Medical School LINCS LIBRARYSee more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Colombo M, et al. Synthesis and biological evaluation of 9-oxo-9H-indeno1,2-bpyrazine-2,3-dicarbonitrile analogues as potentialinhibitors of deubiquitinating enzymes. ChemMedChem. 2010 Apr 6;5(4):552-8.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;/p>