生物藥劑學(xué)與藥物動(dòng)力學(xué)專(zhuān)業(yè)詞匯

1、生物藥劑學(xué)與藥物動(dòng)力學(xué)專(zhuān)業(yè)詞匯Absolute bioavailability, F絕對(duì)生物利用度 Absorption吸收 Absorption pharmacokinetics吸收動(dòng)力學(xué) Absorption routes吸收途徑 Absorption rate吸收速率 Absorption rate constant吸收速率常數(shù) Absorptive epithelium吸收上皮 Accumulation累積 Accumulation factor累積因子 Accuracy準(zhǔn)確度 Acetylation乙?；?Acid glycoprotein酸性糖蛋白 Active transport

2、主動(dòng)轉(zhuǎn)運(yùn) Atomic absorption spectrometry原子吸收光譜法 Additive加和型 Additive errors加和型誤差 Adipose脂肪 Administration protocol給藥方案 Administration route給藥途徑 Adverse reaction不良反應(yīng) Age differences年齡差異 Akaikes information criterion, AICAIC判據(jù) Albumin白蛋白 All-or-none response全或無(wú)效應(yīng) Amino acid conjugation氨基酸結(jié)合 Analog類(lèi)似物 Analy

3、sis of variance, ANOVAANOVA方差分析 Anatomic Volume解剖學(xué)體積 Antagonism拮抗作用 Antiproliferation assays抑制增殖法 Apical membrane頂端表面 Apoprotein載脂蛋白脫輔基蛋白 Apparatus儀器 Apparent volume of distribution表觀分布容積 Area under the curve, AUC曲線下面積 Aromatisation芳構(gòu)化 Artery動(dòng)脈室 Artifical biological membrane人工生物膜 Aryl芳基 Ascorbic aci

4、d抗壞血酸維生素C Assistant in study design輔助實(shí)驗(yàn)設(shè)計(jì) Average steady-state plasma drug concentration平均穩(wěn)態(tài)血漿藥物濃度 Azo reductase含氮還原酶 Backward elimination逆向剔除 Bacteria flora菌叢 Basal membrane基底膜 Base structural model基礎(chǔ)結(jié)構(gòu)模型 Basolateral membrane側(cè)底膜 Bayesian estimation貝易斯氏評(píng)估法 Bayesian optimization貝易斯優(yōu)化法 Bile膽汁 Billiary

5、 clearance膽汁清除率 Biliary excretion膽汁排泄 Binding結(jié)合 Binding site結(jié)合部位 Bioactivation生物活化 Bioavailability, BA生物利用度 Bioequivalence, BE生物等效性 Biological factors生理因素 Biological half life生物半衰期 Biological specimen生物樣品 Biomembrane limit膜限速型 Biopharmaceutics生物藥劑學(xué) Bioequivalency criteria生物等效性判斷標(biāo)準(zhǔn) Biotransformation生

6、物轉(zhuǎn)化 Biowaiver生物豁免 Blood brain barrier, BBBBBB血腦屏障 Blood clearance血液清除率 Blood flow rate-limited models血流速度限速模型 Blood flux in tissue組織血流量 Body fluid體液 Buccal absorption of drug口腔用藥的吸收 Buccal mucosa口腔粘膜頰粘膜 Buccal spray formulation口腔噴霧制劑 Capacity limited容量限制 Carrier mediated transport載體轉(zhuǎn)運(yùn) Catenary model

7、鏈狀模型 Caucasion白種人 Central compartment中央室 Characteristic特點(diǎn) Chelate螯合物 Chinese Traditional medicine products中藥制劑 Cholesterol esterase膽固醇酯酶 Chromatogram色譜圖 Circulation循環(huán) Classification分類(lèi) Clearance清除率 Clinical testing in first phaseI期臨床試驗(yàn) Clinical testing in second phase期臨床試驗(yàn) Clinical testing in third p

8、hase期臨床試驗(yàn) Clinical trial臨床試驗(yàn) Clinical trial simulation臨床實(shí)驗(yàn)計(jì)劃仿真 Clockwise hysteresis loop順時(shí)針滯后回線 Collection采集 Combined administration合并用藥 Combined errors結(jié)合型誤差 Common liposomes, CL普通脂質(zhì)體 Compartment models隔室模型 Compartments隔室 Competitive interaction競(jìng)爭(zhēng)性相互作用 Complements補(bǔ)體 Complex絡(luò)合物 Confidential interval置

9、信區(qū)間 Conjugation with glucuronic acid葡萄糖醛酸結(jié)合 Controlled-release preparations控釋制劑 Control stream控制文件 Conventional tablet普通片 Convergence收斂 Convolution卷積 Corresponding relationship對(duì)應(yīng)關(guān)系 Corticosteroids皮質(zhì)甾體類(lèi) Counter-clockwise hysteresis loop逆時(shí)針滯后回線 Countermeasure對(duì)策 Course in infusion period滴注期間 Covariance

10、協(xié)方差 Covariates相關(guān)因素 Creatinine肌酐 Creatinine clearance肌酐清除率 Cytochrome P450, CYP450細(xì)胞色素P450 Cytoplasm細(xì)胞質(zhì) Cytosis胞飲作用 Cytosol胞漿胞液質(zhì) Data File數(shù)據(jù)文件 Data Inspection檢視數(shù)據(jù) Deamination脫氨基 Deconvolution反卷積 Degree of fluctuation, DFDF波動(dòng)度 Delayed release preparations遲釋制劑 Desaturation降低飽和度 Desmosome橋粒 Desulfuratio

11、n脫硫 Detoxication解毒 Diagnosis診斷 Diffusion擴(kuò)散作用 Dietary factors食物因素 Displacement置換作用 Disposition處置 Dissolution溶解作用 Distribution分布 Dosage adjustment劑量調(diào)整 Dosage form劑型 Dosage form design劑型設(shè)計(jì) Dosage regimen給藥方案 Dose劑量 dose-proportionality study劑量均衡研究 Dropping pills滴丸 Drug absorption via eyes眼部用藥物的吸收 Drug

12、binding藥物結(jié)合 Drug concentration in plasma血漿中藥物濃度 Drug Delivery System, DDS藥物給藥系統(tǒng) Drug interaction藥物相互作用 Drug-plasma protein binding ratio藥物血漿蛋白結(jié)合率 Drug-Protein Binding藥物蛋白結(jié)合 Drug transport to foetus胎內(nèi)轉(zhuǎn)運(yùn)Efficient concentration range有效濃度范圍 Efflux外排 Electrolyte電解質(zhì) Electro-spray ionization, ESI電噴霧離子化 Eli

13、mination消除 Elimination rate constant消除速度常數(shù) Elongation延長(zhǎng) Emulsion乳劑 Endocytosis入胞作用 Endoplasmic reticulum內(nèi)質(zhì)網(wǎng) Enterohepatic cycle腸肝循環(huán) Enzyme酶 Enzyme induction酶誘導(dǎo) Enzyme inhibition酶抑制 Enzyme-linked immunosorbent assays ELISA酶聯(lián)免疫法 Enzymes or carrier-mediated system酶或載體傳遞系統(tǒng) Epithelium cell上皮細(xì)胞 Epoxide hy

14、drolase環(huán)化物水解酶 Erosion溶蝕 Excretion排泄 Exocytosis出胞作用 Exons外顯子 Experimental design實(shí)驗(yàn)設(shè)計(jì) Experimental procedures實(shí)驗(yàn)過(guò)程 Exponential errors指數(shù)型誤差 Exposure-response studies療效研究 Extended least squares, ELS擴(kuò)展最小二乘法 Extended-release preparations緩控釋制劑 Extent of absorption吸收程度 External predictability外延預(yù)見(jiàn)性 Extraction

15、 ratio抽取比 Extract recovery rate提取回收率 Extrapolation外推法 Extravascular administration血管外給藥 F testF檢驗(yàn) Facilitated diffusion促進(jìn)擴(kuò)散 Factors of dosage forms劑型因素 Fasting禁食 Fibronectin纖粘連蛋白 First order rate一級(jí)速度 First Moment一階矩 First order absorption一級(jí)吸收 First-order conditional estimation, FOCE一級(jí)條件評(píng)估法 First-ord

16、er estimation, FO一級(jí)評(píng)估法 Fiest-order kinetics一級(jí)動(dòng)力學(xué) First pass effect首過(guò)作用首過(guò)效應(yīng) Fixed-effect parameters固定效應(yīng)參數(shù) Flavoprotein reductase NADPH細(xì)胞色素還原酶附屬黃素蛋白還原酶 Flow-through cell dissolution method流室法 Fluorescent detection method熒光檢測(cè)法 Fraction of steady-state plasma drug concentration達(dá)穩(wěn)分?jǐn)?shù) Free drug游離藥物 Free dr

17、ug concentration游離藥物濃度Gap junction有隙結(jié)合 Gas chromatography, GC氣相色譜法 Gasrtointestinal tract, GI tract胃腸道 Gender differences性別差異 Generalized additive modeling, GAM通用迭加模型化法 Glimepiride谷胱甘肽 Global minimum整體最小值 Glomerular filtration腎小球過(guò)濾 Glomerular filtration rate, GFR腎小球過(guò)濾率 Glucuonide conjugation葡萄糖醛酸結(jié)合

18、Glutathione conjugation谷胱甘肽結(jié)合 Glycine conjugation甘氨酸結(jié)合 Glycocalyx多糖蛋白質(zhì)復(fù)合體 Goodness of Fit擬合優(yōu)度 Graded response梯度效應(yīng) Graphic method圖解法 Gut wall clearance腸壁清除率 Half life半衰期 Health volunteers健康志愿者 Hemodialysis血液透析 Hepatic artery perfusion administration肝動(dòng)脈灌注給藥 Hepatic clearance, Clh肝清除率 Hierarchical Mode

19、ls相同系列藥物動(dòng)力學(xué)模型 High performance liquid chromatography, HPLC高效液相色譜 Higuchi equation Higuchi方程 Homologous類(lèi)似 Human liver cytochrome P450人類(lèi)肝細(xì)胞色素P450 Hydrolysis水解 Hydroxylation羥基化 Hysteresis滯后 Hysteresis of plasma drug concentration血藥濃度滯后于藥理效應(yīng) Hysteresis of response藥理效應(yīng)滯后于血藥濃度 Immunoradio metrec assays, I

20、RMA免疫放射定量法 Incompatibility配伍禁忌 Independent無(wú)關(guān)，獨(dú)立 Individual parameters個(gè)體參數(shù) Individual variability個(gè)體差異 Individualization of drug dosage regimen給藥方案的個(gè)體化 Inducer誘導(dǎo)劑 Induction誘導(dǎo) Infusion輸注 Inhibition抑制 Inhibitor抑制劑 Initial dose速釋部分 Initial values初始值 Injection sites注射部位 Insulin胰島素 Inter-compartmental clea

21、rance隔室間清除率 Inter-individual model個(gè)體間模型 Inter-individual random effects個(gè)體間隨機(jī)效應(yīng) Inter-individual variability個(gè)體間變異性 Intermittence intravenous infusion間歇靜脈輸液 Internal predictability內(nèi)延預(yù)見(jiàn)性 Inter-occasion random effects實(shí)驗(yàn)間隨機(jī)效應(yīng) Intestinal bacterium flora腸道菌叢 Intestinal metabolism腸道代謝 Intra-individual model

22、個(gè)體內(nèi)模型 Intra-individual variability個(gè)體內(nèi)變異性 Intramuscular administration肌內(nèi)給藥 Intramuscular injection肌內(nèi)注射 Intra-peritoneal administration腹腔給藥 Intravenous administration靜脈給藥 Intravenous infusion靜脈輸液 Intravenous injection靜脈注射 Intrinsic clearance 固有清除率內(nèi)在清除率 Inulin菊粉 In vitro experiments體外試驗(yàn) In vitroIn vivo

23、 correlation, IVIVC體外體內(nèi)相關(guān)關(guān)系 In vitro mean dissolution time, MDT vitro體外平均溶出時(shí)間 In vivo Mean dissolution time, MDT vivo體內(nèi)平均溶出時(shí)間 Ion exchange離子交換 Isoform異構(gòu)體 Isozyme 同工酶Kerckring環(huán)狀皺褶Kidney腎Lag time滯后時(shí)間 Laplace transform拉普拉斯變換 Lateral intercellular fluid側(cè)細(xì)胞間隙液 Lateral membrane側(cè)細(xì)胞膜 Least detection amount最

24、小檢測(cè)量 Linearity線性 Linear models線性模型 Linear regression method線性回歸法 Linear relationship線性關(guān)系 Lipoprotein脂蛋白 Liposomes脂質(zhì)體 Liver flow肝血流 Local minimum局部最小值 Loading dose負(fù)荷劑量 Logarithmic models對(duì)數(shù)模型 Long circulation time liposomes長(zhǎng)循環(huán)脂質(zhì)體 Loo-Riegelman methodLoo-Riegelman法 Lowest detection concentration最低檢測(cè)濃度

25、Lowest limit of quantitation定量下限 Lowest steady-state plasma drug concentration最低穩(wěn)態(tài)血藥濃度 Lung clearance肺清除率 Lymphatic circulation淋巴循環(huán) Lymphatic system淋巴系統(tǒng)Maintenance dose維持劑量 Mass balance study質(zhì)量平衡研究 Masticatory mucosa咀嚼粘膜 Maximum likelihood最大似然性 Mean absolute prediction error, MAPE平均絕對(duì)預(yù)測(cè)誤差 Mean absor

26、ption time, MAT平均吸收時(shí)間 Mean disintegration time, MDIT平均崩解時(shí)間 Mean dissolution time, MDT平均溶出時(shí)間 Mean residence time, MRT平均駐留時(shí)間 Mean sojourn time平均逗留時(shí)間 Mean squares均方 Mean transit time平均轉(zhuǎn)運(yùn)時(shí)間 Membrane-limited models膜限速模型 Membrane-mobile transport膜動(dòng)轉(zhuǎn)運(yùn) Membrane transport膜轉(zhuǎn)運(yùn) Metabolism代謝 Metabolism enzymes代謝

27、酶 Metabolism locations代謝部位 Metabolites代謝物 Metabolites clearance, Clm代謝物清除率 Method of residuals殘數(shù)法剩余法 Methylation甲基化 Michaelis-Menten equation米氏方程 Michaelis-Menten constant米氏常數(shù) Microbial assays微生物檢定法 Microsomal P450 mixed-function oxygenases肝微粒體P-450混合功能氧化酶 Microspheres微球 Microvilli微絨毛 Minimum drug c

28、oncentration in plasma血漿中最小藥物濃度 Mixed effects modeling混合效應(yīng)模型化 Mixed-function oxidase, MFO混合功能氧化酶 Models模型 Modeling efficiency模型效能 Model validation模型驗(yàn)證 Modified release preparations調(diào)釋制劑 Molecular mechanisms分子機(jī)制 Mono-exponential equation單指數(shù)項(xiàng)公式 Mono-oxygenase單氧加合酶 Mucous membrane injury粘膜損傷 Multi-compa

29、rtment models多室模型延遲分布模型 Multi-exponential equation多指數(shù)項(xiàng)公式 Multifactor analysis of variance, multifactor ANOVA多因素方差分析 Multiple dosage多劑量給藥 Multiple-dosage function多劑量函數(shù) Multiple-dosage regimen多劑量給藥方案 Multiple intravenous injection多次靜脈注射 Myoglobin肌血球素Naive average data, NAD簡(jiǎn)單平均數(shù)據(jù)法 Naive pool data, NPD簡(jiǎn)

30、單合并數(shù)據(jù)法 Nanoparticles納米粒 Nasal cavity鼻腔 Nasal mucosa鼻粘膜 National Institute of Health美國(guó)國(guó)立衛(wèi)生研究所 Nephron腎原 Nephrotoxicity腎毒性 No hysteresis無(wú)滯后 Non-compartmental analysis, NCA非隔室模型法 Non-compartmental assistant Technology非隔室輔助技術(shù) Nonionized form非離子型 Nonlinear mixed effects models, NONMEM非線性混合效應(yīng)模型 Nonlinear

31、pharmacokinetics非線性藥物動(dòng)力學(xué) Non-linear relationship非線性關(guān)系 Nonparametric test非參數(shù)檢驗(yàn) Objective function, OF目標(biāo)函數(shù) Observed values觀測(cè)值 One-compartment model一室模型（單室模型） Onset發(fā)生 Open randomized two-way crossover design開(kāi)放隨機(jī)兩路交叉實(shí)驗(yàn)設(shè)計(jì) Open crossover randomized design開(kāi)放交叉隨機(jī)設(shè)計(jì) Oral administration口服給藥 Ordinary least squ

32、ares, OLS常規(guī)最小二乘法 Organ器官 Organ clearance器官清除率 Original data原始數(shù)據(jù) Osmosis滲透壓作用 Outlier偏離數(shù)據(jù) Outlier consideration異常值的考慮 Over-parameterized過(guò)度參數(shù)化 Oxidation氧化 Oxidation reactions氧化反應(yīng)Paracellular pathway細(xì)胞旁路通道 Parameters參數(shù) Passive diffusion被動(dòng)擴(kuò)散 Pathways途徑 Patient病人 Peak concentration峰濃度 Peak concentration

33、of drug in plasma血漿中藥物峰濃度 Poly-peptide多肽 Percent of absorption吸收百分?jǐn)?shù) Percent of fluctuation, PF波動(dòng)百分?jǐn)?shù) Perfused liver灌注肝臟 Period周期 Peripheral compartments外周室 Peristalsis蠕動(dòng) Permeability of cell membrane細(xì)胞膜的通透性 P-glycoprotein, p-gpP-糖蛋白 Phagocytosis吞噬 Pharmaceutical dosage form藥物劑型 pharmaceutical equival

34、ents藥劑等效性 Pharmacokinetic models藥物動(dòng)力學(xué)模型 Pharmacokinetic physiological models藥物動(dòng)力學(xué)的生理模型 Pharmacological effects藥理效應(yīng) Pharmacologic efficacy藥理效應(yīng) Pharmacokinetics, PK藥物動(dòng)力學(xué) Pharmacokinetic/pharmacodynamic link model藥物動(dòng)力學(xué)-藥效動(dòng)力學(xué)統(tǒng)一模型 Pharmacodynamics, PD藥效動(dòng)力學(xué) Pharmacodynamic model藥效動(dòng)力學(xué)模型 Phase II metabolism

35、第II相代謝 Phase I metabolism第I相代謝 pH-partition hypothesispH分配假說(shuō) Physiological function生理功能 Physiological compartment models生理房室模型 Physiological pharmacokinetic models生理藥物動(dòng)力學(xué)模型 Physiological pharmacokinetics生理藥物動(dòng)力學(xué)模型 Pigment色素 Physicochemical factors理化因素 Physicochemical property of drug藥物理化性質(zhì) Physiologi

36、cal factors生理因素 Physiology生理 Physiological pharmacokinetic models生理藥物動(dòng)力學(xué)模型 Pinocytosis吞噬 Plasma drug concentration血漿藥物濃度 Plasma drug concentrationtime curve血漿藥物濃度-時(shí)間曲線 Plasma drug-protein binding血漿藥物蛋白結(jié)合 Plasma metabolite concentration血漿代謝物濃度 Plasma protein binding血漿蛋白結(jié)合 Plateau level坪濃度 Polymorphis

37、m多態(tài)性 Population average pharmacokinetic parameters群體平均動(dòng)力學(xué)參數(shù) Population model群體模型 Population parameters群體參數(shù) Population pharmacokinetics群體藥物動(dòng)力學(xué) Post-absorptive phase吸收后相 Post-distributive phase分布后相 Posterior probability后發(fā)概率 practical pharmacokinetic program實(shí)用藥代動(dòng)力學(xué)計(jì)算程序 Precision精密度 Preclinical臨床前的 Pred

38、iction errors預(yù)測(cè)偏差 Prediction precision預(yù)測(cè)精度 Predicted values擬合值 Preliminary structural model初始結(jié)構(gòu)模型 Primary active transport原發(fā)性主動(dòng)轉(zhuǎn)運(yùn) Principle of superposition疊加原理 Prior distribution前置分布 Prodrug前體藥物 Proliferation assays細(xì)胞增殖法 Proportional比例型 Proportional errors比例型誤差 Prosthehetic group輔基 Protein蛋白質(zhì) Pseud

39、o-distribution equilibrium偽分布平衡 Pseudo steady state偽穩(wěn)態(tài) Pulmonary location肺部 Pulsatile drug delivery system脈沖式釋藥系統(tǒng) QQuality controlled samples質(zhì)控樣品 Quality control質(zhì)量控制 Quick tissue快分布組織 RRadioimmuno assays, RIA放射免疫法 Random error model隨機(jī)誤差模型 Rapid intravenous injection快速靜脈注射 Rate constants速度常數(shù) Rate met

40、hod速度法 Re-absorption重吸收 Receptor location受體部位 Recovery回收率 Rectal absorption直腸吸收 Rectal blood circulation直腸部位的血液循環(huán) Rectal mucosa直腸黏膜 Reductase還原酶 Reduction還原 Reductive metabolism還原代謝 Reference individual參比個(gè)體 Reference product參比制劑 Relative bioavailability, Fr相對(duì)生物利用度 Release釋放 Release medium釋放介質(zhì) Releas

41、e standard釋放度標(biāo)準(zhǔn) Renal腎的 Renal clearance, Clr腎清除率 Renal excretion腎排泄 Renal failure腎衰 Renal impairment腎功能衰竭 Renal tubular腎小管 Renal tubular re-absorption腎小管重吸收 Renal tubular secretion腎小管分泌 Repeatability重現(xiàn)性 Repeated one-point method重復(fù)一點(diǎn)法 Requirements要求 Research field研究?jī)?nèi)容 Reside駐留 Respiration呼吸 Respirati

42、on organ呼吸器官 Response效應(yīng) Residuals殘留誤差 Residual random effects殘留隨機(jī)效應(yīng) Reversal恢復(fù) Rich Data富集數(shù)據(jù) Ritschel one-point method Ritschel一點(diǎn)法 Rotating bottle method轉(zhuǎn)瓶法 Rough surfaced endoplasmic reticulum粗面內(nèi)質(zhì)網(wǎng) Routes of administration給藥途徑SSafety and efficacy therapy安全有效用藥 Saliva唾液 Scale up外推 Scale-Up/Post-Appr

43、oval Changes, SUPAC放大/審批后變化 Second moment二階矩 Secondary active transport繼發(fā)性主動(dòng)轉(zhuǎn)運(yùn) Secretion分泌 Sensitivity靈敏度 Serum creatinine血清肌酐 Sigma curve西格瑪曲線 Sigma-minus method虧量法（總和減量法） Sigmoid curveS型曲線 Sigmoid modelHills方程 Simulated design模擬設(shè)計(jì) Single-dose administration單劑量（單次）給藥 Single dose response單劑量效應(yīng) Sink

44、condition漏槽條件 Skin皮膚 Slow Tissue慢分布組織 Smooth surfaced endoplasmic reticulum滑面內(nèi)質(zhì)網(wǎng) Soluble cell sap fraction可溶性細(xì)胞液部分 Solvent drag effect溶媒牽引效應(yīng) Stability穩(wěn)定性 Steady-state volume of distribution穩(wěn)態(tài)分布容積 Sparse data稀疏數(shù)據(jù) Special dosage forms特殊劑型 Special populations特殊人群 Specialized mucosa特性粘膜 Species種屬 Specie

45、s differences種屬差異 Specificity特異性專(zhuān)屬性 Square sum of residual error殘差平方和 Stagnant layer不流動(dòng)水層 Standard curve標(biāo)準(zhǔn)曲線 Standard two stage, STS標(biāo)準(zhǔn)兩步法 Statistical analysis統(tǒng)計(jì)分析 Statistical moments統(tǒng)計(jì)矩 Statistical moment theory統(tǒng)計(jì)矩原理 Steady state穩(wěn)態(tài) Steady state plasma drug concentration穩(wěn)態(tài)血藥濃度 Stealth liposomes, SL隱形

46、脂質(zhì)體 Steroid類(lèi)固醇 Steroid-sulfatases類(lèi)固醇硫酸酯酶 Structure結(jié)構(gòu) Structure and function of GI epithelial cells胃腸道上皮細(xì)胞的構(gòu)造與功能 Subcutaneous injections皮下注射 Subgroup亞群體 Subjects受試者 Sublingual administration舌下給藥 Sublingual mucosa舌下粘膜 Subpopulation亞群 Substrate底物 Sulfate conjugation硫酸鹽結(jié)合 Sulfation硫酸結(jié)合 Sum of squares平方和 Summation相加 Superposition method疊加法 Susceptible subject易受影響的患者 Sustained-release preparations緩