Maropitant _Neurokinin Receptor Antagonist - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEMaropitantCat. No.: HY-10053CAS No.: 147116-67-4分式: CHNO分量: 468.67作靶點(diǎn): Neurokinin Receptor作通路: GPCR/G Protein; Neuronal Signaling儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 33.33 mg/mL

2、(71.12 mM; Need ultrasonic)H2O : 90% corn oilSolubility: 2.5 mg/mL (5.33 mM); Clear solutionBIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE物活性 Maropitant是神經(jīng)激肽（NK1）受體拮抗劑。REFERENCES1. Hay Kraus BL. Efficacy of maropitant in preventing vomiting in dogs premedicated with hydromorpho

3、ne. Vet Anaesth Analg. 2013Jan;40(1):28-34.2. Lesman SP, Boucher JF, Grover GS, et al. The pharmacokinetics of maropitant citrate dosed orally to dogs at 2 mg/kg and 8 mg/kgonce daily for 14 days consecutive days. J Vet Pharmacol Ther. 2012 Nov 20.3. Alvillar BM, Boscan P, Mama KR, et al. Effect of

4、epidural and intravenous use of the neurokinin-1 (NK-1) receptor antagonist maropitanton the sevoflurane minimum alveolar concentration (MAC) in dogs. Vet Anaesth Analg. 2012 Mar;39(2):201-5.4. Ramsey DS, Kincaid K, Watkins JA et al. Safety and efficacy of injectable and oral maropitant, a selective

5、 neurokinin 1 receptorantagonist, in a randomized clinical trial for treatment of vomiting in dogs. J Vet Pharmacol Ther. 2008 Dec;31(6):538-43. doi:10.1111/j.1365-2885.2008.00992.x.5. Benchaoui HA, Cox SR, Schneider RP et al. The pharmacokinetics of maropitant, a novel neurokinin type-1 receptor antagonist, in dogs.J Vet Pharmacol Ther. 2007 Aug;30(4):336-44.6. MaropitantMcePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;