呼吸系統(tǒng)藥理學(xué)醫(yī)學(xué)ppt課件

1、glucocorticosteroids mediator release inhibitorsONCH3HOH3COdisorders, etc. Mesna 美司鈉美司鈉Asthma Asthma is physiologically characterized by increased responsiveness of the trachea and bronchi to various stimuli and by widespread narrowing of the airways that changes in severity either spontaneously or

2、as a result of therapy. Its pathologic features are contraction of airway smooth muscle, mucosal thickening from edema and cellular infiltration, and inspissation in the airway lumen of abnormally thick, viscid plugs of mucus. Symptom: dyspnea, wheezing, stridor, coughing, an inability for physical

3、exertion. The cough may sometimes produce clear sputum. Between episodes, most patients feel well but can have mild symptoms and they may remain short of breath after exercise for longer periods of time than the unaffected individual. Asthmaless systemic toxicityNNNNH3CHCH2NH22H2OCH2NH2OOCH3- - - -

4、-2. . .secretion, etc.OCCH2CH2CH2C6H5CHOCHCH3CH3CHNCH3CHOH(CH3)2CHOHOClCH3OCOC2H5COCH2OCOC2H5OONaOOCCOONaOCH2CHCH2OOHOOLeukotriene pathway inhibitors Airways LTC4, LTD4, LTE4-bronchoconstrictors, increase microvascular permeability, mucus secretion LTB4-chemoattractant for neutrophils Leukotriene pathway inhibitors CysLT1 receptor antagonist (zafirlukast): for mild or moderate as