結(jié)腸水療與莫沙必利治療慢性功能性便秘的臨床對(duì)照觀察

1、結(jié)腸水療與莫沙必利治療慢性功能性便秘的臨床對(duì)照觀察作者：仲惠杜平彭麗瓊梅永紅劉程麗資艷妮陳志 航【摘要】目的：觀察結(jié)腸水療對(duì)慢性功能性便秘(cfc)的治療效果。 方法：將cfc患者203例隨機(jī)分a組66例，行結(jié)腸水療；b組69例， 行結(jié)腸水療及服用枸椽酸莫沙必利治療；c組68例，服用枸椽酸莫 沙必利治療。2周后觀察療效。結(jié)果：a, b, c 3組有效率分別為： 78.79% ( 52/66 )、86.96% ( 60/69 ). 72. 06% ( 49/68 )。經(jīng)統(tǒng)計(jì)學(xué)處理 b, c兩組療效有明顯差異(p<0. 05),觀察有顯效及有效者3、6 個(gè)月,a組分別有14 ( 26

2、.92%)、18例(34.62% )復(fù)發(fā);b組分別有 17 ( 28. 33%)、20 例(33. 33%)復(fù)發(fā)，c 組分別有 31 ( 63. 27%)、39 例( 79.59%)復(fù)發(fā)。a, b結(jié)腸水療組復(fù)發(fā)率明顯低于枸椽酸莫沙必 利治療組(p<0. 05)o結(jié)論：結(jié)腸水療治療慢性功能性便秘效果好, 治愈后復(fù)發(fā)率低?！娟P(guān)鍵詞】結(jié)腸水療；莫沙必利；慢性功能性便秘abstract objective: to evaluate the effect of colonhydrotherapy in the treatment of functional constipation.met

3、hods: a total of 203 patients with functional constipation were randomizedly divided into three groups group a received colon hydrotherapy. group b received colon hydrotherapy and taken mosapride group c taken mosapride only. the treatment lasted 2 weeks results: the effective rate in group a, b and

4、 c was 7& 79% (52/66), 86. 96% (60/69), 72.06% (49/68), respectively. there was significantly difference in effective rate between group b and group c (p⁢ 0. 05). follow up for three and six months, recurrence rate at three month in group a, b and c was 26.92%, 2& 33%, and 63.27%, res

5、pectively, and at six month was 34. 62%, 33. 33% and 79. 59%, respectively. the recurrence rates in colon hydrotherapy groups were lower than that in the mosapride group (p⁢0.05). conclusions: colon hydrotherapy is more effective than mosapride in the treatment of functional constipationkey w

6、ords functional constipation, colon hydrotherapy慢性功能性便秘(cfc)嚴(yán)重影響現(xiàn)代人的生活質(zhì)量，其發(fā)病機(jī)制不 完全清楚，傳統(tǒng)的治療方法主要是交替選擇通便藥物的對(duì)癥治療及胃 腸動(dòng)力藥治療，有一定療效1,2,但停藥后，復(fù)發(fā)率高。結(jié)腸水療 是通過結(jié)腸途徑治療系統(tǒng)對(duì)結(jié)腸進(jìn)行清洗、灌藥，效果滿意，為總結(jié) 經(jīng)驗(yàn)，我們對(duì)結(jié)腸水療與枸椽酸莫沙必利片進(jìn)行臨床觀察比較觀察, 報(bào)告如下。1資料與方法1. 1觀察對(duì)象：2005年3月至2006年12月住院及門診cfc患者 203例，其中男67例，女136例，年齡1671歲，平均47歲。隨 機(jī)分a組（結(jié)腸水療）66例、b

7、組（結(jié)腸水療加枸椽酸莫沙必利）69 例、c組（枸椽酸莫沙必利）68例。3組患者年齡、性別相似有可比 性。1.2對(duì)象入選標(biāo)準(zhǔn)3:便秘癥狀持續(xù)3個(gè)月以上，排除器質(zhì)性疾 病，并具備下述兩個(gè)或兩個(gè)以上條件：自發(fā)性排便次數(shù)2次/周； 25%以上時(shí)間排便困難；25%以上時(shí)間糞質(zhì)較硬或硬球狀；25% 以上時(shí)間排便有不盡感或不暢；近一年內(nèi)曾做過結(jié)腸鏡或領(lǐng)劑灌腸 檢查，除外結(jié)腸器質(zhì)性病變。1.3治療方法:a組：患者排便后取左側(cè)臥位，屈曲雙下肢。用結(jié) 腸清洗液5000 10000 ml,通過ims 100a結(jié)腸途徑治療系統(tǒng)（北 京智立醫(yī)學(xué)儀器有限公司生產(chǎn)）清洗結(jié)腸，將結(jié)腸內(nèi)糞便、細(xì)菌、毒 素等排除體外，然后將甲硝哇注射液100 ml.慶大霉素24萬(wàn)u、地 塞米松注射液5 mg注入結(jié)直腸內(nèi)，1次/2 d, 7次為一療程，