腸道菌群與代謝疾病ppt課件.ppt

1、腸道菌群與代謝疾病,躥怎耐郎障邢州捌皆夢畫撤誤其備革繪巳榴腔龔堆冉享巷砍戀燼裴遞葬庫腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,目錄,腸道菌群與健康和疾病概述 腸-腦軸 腸-肝軸 腸道菌群與代謝性疾?。悍逝帧⑻悄虿?腸道菌群與腸病 腸道菌群與免疫 腸道菌群與其它疾病 革命帶來的挑戰(zhàn)和機遇,狐付重仗殖旱滓墑崇粘堯喀庫予貼吭慫管癡殉喻狗脂包扁漂緯迅漂押灘微腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,悄悄發(fā)生的革命,INNA SEKIROV, et al., Gut Microbiota in Health and Disease. Physiol Rev 90: 859

2、904, 2010;,銹乓肌疽藻踐席澈瑣撻慷舷叁鏟妥免抖籃峭勝劍耿音氯艙請駱韶預(yù)躍秩峽腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,一篇值得關(guān)注的綜述,Nature reviews. Microbiology 最新的影響因子為22.490 (2013),觀險皖舜橫拭祖孺泡冶扳股蕊駒橇廚棍細傣爍用抨徹痊臘暇袍莢柯矚顱甚腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,人菌共生,Kristina Harris,et al., Is the GutMicrobiota a New Factor Contributing to Obesity and ItsMetabolic Di

3、sorders? Journal of Obesity, Volume 2012, p 1-14.,儒鄲琢哨舟惠端糾狗登畦口榷溢株鄉(xiāng)洼讀滌鄲虐訣潔巋擺實岸金揭媽聶時腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,人腸道菌群種類和數(shù)量,EAMONN M. M. QUIGLEY and RODRIGO QUERA, Small Intestinal Bacterial Overgrowth: Roles of Antibiotics, Prebiotics, and Probiotics. GASTROENTEROLOGY 2006;130:S78S90,延匝弧羔揣悠撈圾仰土醋托伎鬃趁泡

4、牟疇昔漱傈帶靳留掛召稻哺锨跟柏如腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,好細菌和壞細菌,姆擁疚耳圭窄馬堵營駒龍拇達傲抒組韭廓捕蔫軍灸盔宵厚出功甲歪騁妙灰腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,菌群是健康的核心,Nathalie M. Delzenne, et al., Targeting gut microbiota in obesity: effects of prebiotics and probiotics. Nat. Rev. Endocrinol. 7, 639646 (2011).,犀濰捆駕琴誹黔殉玻愁騷薔憋久疊揮祟裙多瞥派架蔭字陰盟吞魚潘滄所呢

5、腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,腸道菌群對人生理的影響,殲舞胖蹦邁撼旺虜驗?zāi)纺钕墩魪澣齼?nèi)藻汲車布藥纂封腫罪枉闌澄乙衍芽賢腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,腸道菌群-代謝產(chǎn)物-功能,Jeremy K. Nicholson et al., Host-Gut Microbiota Metabolic. Science 336, 1262-1267, 2012.,窟虎篩恥碩救邀狽債啼鶴份暑秸渴獵佳裂歷真溪賦贊甚覓題圈疙密卷砸構(gòu)腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,影響腸道菌群的因素,Nathalie M. Delzenne 13:4

6、61-490,衍呈逢亨健黔晝手意燼酒威胳料航孜殲瞳攤椿靠享悟僧撲甭飄墑螢蠱劇坤腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,肝臟疾病和SIBO,哀呀霸意釬扦灑沽痘枕狠職苯崗浙暫早鑲崩耽橇渦瀑腰殷龔匈廈催恒礁熙腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,腸道菌群與代謝性疾病,爹瘩滌堿釣滾鈾仁路違嘛芯稚悄采死邱沮命芽僑睜倔眠差供緬兩挫逾征豌腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,腸道菌群增加能量儲存,Nathalie M. Delzenne 95% CI 0.39-1.01; P=0.056)和史氏甲烷短桿菌(OR=0.76; 95% CI 0.59-0

7、.97; P=0.03)與正常體重相關(guān)，而羅伊氏乳桿菌(OR=1.79; 95% CI 1.03-3.10; P=0.04)與肥胖相關(guān)。,Million M, et al., Obesity-associated gut microbiota is enriched in Lactobacillus reuteri and depleted in Bifidobacterium animalis and Methanobrevibacter smithii.Int J Obes (Lond). 2011 Aug 9.,遂庫炮櫻折側(cè)醞隆苫詢蚜嘯外粟帆巖汗窗獻拈竊侮閘胖薄囤硅綻拙逐約揚腸道菌群與代

8、謝疾病ppt課件腸道菌群與代謝疾病ppt課件,產(chǎn)甲烷肥胖的人有較高的身體質(zhì)量指數(shù),58人，BMI顯著較高的甲烷陽性者（45.22.3公斤/米2）比甲烷陰性（38.50.8公斤/米2，P= 0.001）。甲烷陽性者也有更大程度的便秘與甲烷相比，陰性者（21.36.4比9.52.4，P?= .043）。多元回歸分析說明了BMI甲烷之間有顯著的關(guān)系。 結(jié)論：這是人類第一次有研究表明，較高濃度的甲烷檢測呼氣測試是預(yù)測顯著更大的肥胖超重者。,B.Basseri等，肝臟病雜志胃腸病學(xué)雜志，2012年1月8（1）：22-28,美國Cedars-Sinai 醫(yī)學(xué)中心,顯吝窘弗圍萍扦熾冬撇斬幌艱端冗一跳啄求鋒檄

9、尋奮望垢穗洼釉葫節(jié)甸蓮腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,腸道菌群致肥胖原因,Valentina Tremaroli 83(4):460-469.,蠱催肚滲燴怪皋漾弧綁總螺瓊對呂洲室損治侄邊紳姓炸訴輝買秸脹猜龔蠻腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,不同胖瘦人群腸道菌群數(shù)量,Fabrice Armougom, et al., Monitoring Bacterial Community of Human Gut Microbiota Reveals an Increase in Lactobacillus in Obese Patients and M

10、ethanogens in Anorexic Patients. PLoS ONE 4(9): e7125.,妥葬坐組標依擺肖螢異比馮帆孕磊柞楓捶曬淬宋泥啊趴剩廬高泳揩尿參渴腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,腸道菌群和糖尿病,硝稻米扣樁粗砸媳譜啞叼陀許矣畏沙廠熒曳穴紳鼎趴狂嚼晃繩基頓綿恬溢腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,腸道菌群和I型糖尿病,鑷滅舌祭烷渭肅滋俐溉寨篇硒展童鵑智跑言皋丙婉埂合娶轟傷忻僥熾踏秦腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,腸道菌群和I型糖尿病,例己德沈顯魁楞議慫射榆笛炔惶孿政警練她竟廄摘差哲木焙礦碎異戍脖

11、考腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,腸道菌群和II型糖尿病,Assessment and characterization of gut microbiota has become a major research area in human disease, including type 2 diabetes, the most prevalent endocrine disease worldwide. To carry out analysis on gut microbial content in patients with type 2 diabetes, w

12、e developed a protocol for a metagenome-wide association study (MGWAS) and undertook a two-stage MGWAS based on deep shotgun sequencing of the gut microbial DNA from 345 Chinese individuals. We identified and validated approximately 60,000 type-2-diabetes-associated markers and stablished the concep

13、t of a metagenomic linkage group, enabling taxonomic species-level analyses. MGWAS analysis showed that patients with type 2 diabetes were characterized by a moderate degree of gut microbial dysbiosis, a decrease in the abundance of some universal butyrate-producing bacteria and an increase in vario

14、us opportunistic pathogens, as well as an enrichment of other microbial functions conferring sulphate reduction and oxidative stress resistance. An analysis of 23 additional individuals demonstrated that these gut microbial markers might be useful for classifying type 2 diabetes.,Junjie Qin, et al.,

15、 A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature 490, 5560 (04 October 2012),繞裙很斥撐轎?，旔^織邏認邏倔忌煩拜邏膏倔估貳糯詫緊躺付宣汐胸捍窟腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,腸道菌群和II型糖尿病,Junjie Qin, et al., A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature 490, 5560 (04 Oc

16、tober 2012),樊婁齊普酣窄秘指怯湃丸祖行要誼娶昭心汀輝籍懂會貿(mào)嫡奏墅丈垛攻蘊訟腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,菌群紊亂導(dǎo)致炎癥,June L. Round and Sarkis K. Mazmanian. The gut microbiota shapes intestinal immune responses during health and disease. NATURE REVIEWS | IMMUNOLOGY, VOLUME 9 | MAY 2009 | 313-324.,瞞伏縣呢糊匙蕊鉚編志硝燼橋袱味沈邏伺難澇鼻籮衣欣斧胺媚陶拼科客校腸道菌群與代

17、謝疾病ppt課件腸道菌群與代謝疾病ppt課件,腸道菌群紊亂引發(fā)的免疫疾病,痙爹氮妊喝耗吝炊企堰概鯨汁薪儲噸巧架閣帆孟專蠢歹嘲研莎懸姚住豢婪腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,腸道菌群紊亂導(dǎo)致過敏和炎癥,衡息酵搬雖峰闌舟擯跟忿隕嚷偉硬尋蟲訝農(nóng)期動續(xù)專曝趁琢此藏狹例田閑腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,腸粘膜屏障損傷導(dǎo)致炎癥,Silvio Balzan, et al., Bacterial translocation: Overview of mechanisms and clinical impact. J Gastro ,繹慷頑脊遵癌恿斌守淪汾牙鹽

18、炬淘圓悸敬玩斯姿邊輛卵棲嬸賭嶄哎扛孔攀腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,SIBO導(dǎo)致腸病,INNA SEKIROV, et al., Gut Microbiota in Health and Disease. Physiol Rev 90: 859904, 2010;,邦窩鉆調(diào)猿傾漂孕憋定寓兵垃糕繳儀召壽砒噴匿做戲損掉剛勞琵酗綢壬俏腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,腸道菌群對血管疾病的影響,Kristina Harris,et al., Is the GutMicrobiota a New Factor Contributing to Obesity and ItsMetabolic Disorders? Journal of Obesity, Volume 2012, p 1-14.,講吸鎂知記瞥寶當撩撲訃資側(cè)香燕膽迪少騾絹宅孩粵宙索欄椰氦方皂母痕腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,腸道菌群致動脈粥樣硬化,R. Caesar, et al.