rac-Lomedeucitinib-rac-BMS-986322-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemE(rac)-LomedeucitinibCat.No.:HY-160144S2CASNo.:2328064-33-9Synonyms:(rac)-BMS-986322分?式:C??H??D?N?O?S分?量:419.47作?靶點(diǎn):Others作?通路:Others儲(chǔ)存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:25mg/mL(59.60mM;ultrasonicandwarmingandheatto60°C)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM2.3840mL11.9198mL23.8396mL5mM0.4768mL2.3840mL4.7679mL10mM0.2384mL1.1920mL2.3840mLBIOLOGICALACTIVITY?物活性(rac)-Lomedeucitinib((rac)-BMS-986322)Lomedeucitinib的外消旋體。Lomedeucitinib(BMS-986322)是?種酪氨酸蛋?激酶(tyrosineproteinkinase(TYK2))抑制劑。Lomedeucitinib具有抗炎活性，對(duì)IL-12/TYK2下游IFNα產(chǎn)?具有顯著的抑制作?(IC50=0.047μM)。Lomedeucitinib可?于斑塊狀銀屑病和瘙癢的研究。REFERENCES[1].DrakosA,etal.EmergingOralTherapiesfortheTreatmentofPsoriasis:AReviewofPipelineAgents[J].Pharmaceutics,2024,16(1):1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE111.[2].ZhangK,etal.Developmentandtherapeuticimplicationsoftyrosinekinase2inhibitors[J].JournalofMedicinalChemistry,2023,66(7):4378-4416.[3].AndrewNicholasBillin,etal.Il-31modulatorsfortreatingfxr-inducedpruritis.WO2022266444A1.2022-06-17McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:021-5