GM-60186-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEGM-60186Cat.No.:HY-169229分?式:C??H??FN?O?分?量:504.59作?靶點(diǎn):5-HTReceptor作?通路:GPCR/GProtein;NeuronalSignaling儲(chǔ)存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性GM-60186?種5-HT受體2B(HTR2B)抑制劑，IC50為257nM。GM-60186可顯著抑制結(jié)直腸癌的增殖和遷移。IC50&Target5-HT2BReceptor257nM(IC50)體外研究GM-60186(50-500?nM;72hours)effectivelyinhibitstheproliferationincolorectalcancer(CRC)cells[1].GM-60186(500?nM;24-48hours)effectivelyinhibitscolorectalcancermigration[1].CellViabilityAssay[1]CellLine:COLO-205,MC38,CT26andCaco2cellsConcentration:0,50,100,and500?nMIncubationTime:72hoursResult:DemonstratedeffectiveinhibitionofcellproliferationintheseCRCcelllines.CellMigrationAssay[1]CellLine:COLO-205,CT26andMC38cellsConcentration:500?nMIncubationTime:24,and48?h1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEResult:Inhibitedcolorectalcancermigration.體內(nèi)研究GM-60186(10-20mg/kg;IP;daily;for20days)significantlyreducestumorsizeandweightinxenograftmousemodels[1].AnimalModel:HomozygousmaleBALB/cnudemice(CAnN.Cg-Foxn1nu/Crl;8-week-old)injectedwithCOLO-205cells[1]Dosage:10mg/kg;20mg/kgAdministration:IP;daily;for20daysResult:Significantlyreducedtumorsizeandweight.REFERENCES[1].Jeong-YunLee,etal.InhibitionofHTR2B-mediatedserotoninsignalingincolorectalcancersuppressestumorgrowththroughERKsignaling.BiomedPharmacother.2024Oct:179:117428.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-58