Flupirtine-hydrochloride-D-9998-hydrochloride-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEFlupirtinehydrochlorideCat.No.:HY-W709349CASNo.:33400-45-2Synonyms:D9998hydrochloride分?式:C??H??ClFN?O?分?量:340.78作?靶點(diǎn):PotassiumChannel;iGluR作?通路:MembraneTransporter/IonChannel;NeuronalSignaling儲(chǔ)存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Flupirtinehydrochloride(D9998hydrochloride)?種選擇性的神經(jīng)鉀通道開放劑，具有鎮(zhèn)痛活性。Flupirtinehydrochloride被?于抑制各種疼痛狀態(tài)，包括慢性肌??骼疼痛、偏頭痛和神經(jīng)痛等。Flupirtinehydrochloride具有抗抑郁和抗氧化的特性，并能增加與嗎啡的聯(lián)合療法中的鎮(zhèn)痛作?。Flupirtinehydrochloride能夠緩解異常增加的肌?緊張，并具有肌?松弛作?。Flupirtinehydrochloride在臨床中相較于其他藥物，如曲馬多和潘妥昔，再加上副作?的耐受性更優(yōu)。Flupirtinehydrochloride對(duì)抑制神經(jīng)過度興奮具有顯著效果，因此在各種疼痛狀態(tài)中展現(xiàn)出抑制潛?。REFERENCES[1].KornhuberJ,etal.FlupirtineshowsfunctionalNMDAreceptorantagonismbyenhancingMg2+blockviaactivationofvoltageindependentpotassiumchannels.Rapidcommunication.JNeuralTransm.1999;106(9-10):857-67.[2].KlingerF,etal.ConcomitantfacilitationofGABAAreceptorsandKV7channelsbythenon-opioidanalgesicflupirtine.BrJPharmacol.2012Jul;166(5):1631-42.[3].SwedbergMD,etal.Pharmacologicalmechanismsofactionofflupirtine:anovel,centrallyacting,nonopioidanalgesicevaluatedbyitsdiscriminativeeffectsintherat.JPharmacolExpTher.1988Sep;246(3):1067-74.[4].WuSN,etal.Evidenceforinhibitoryeffectsofflupirtine,acentrallyactinganalgesic,ondelayedrectifierk(+)currentsinmotorneuron-likecells.EvidBasedComplementAlternatMed.2012;2012:148403.[5].KolosovA,etal.Flupirtineenhancestheanti-hyperalgesiceffectsofmorphineinaratmodelofprostatebonemetastasis.PainMed.2012Nov;13(11):1444-56.[6].MichelMC,etal.Unexpectedfrequenthepatotoxicityofaprescriptiondrug,flupirtine,marketedforabout30years.BrJClinPharmacol.2012May;73(5):821-5.1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE[7].Flupirtineinpainmanagement:pharmacologicalpropertiesandclinicaluseMcePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel: