Eicosapentaenoic-acid-metformin-EPA-metformin-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEEicosapentaenoicacid(metformin)Cat.No.:HY-B0660ACASNo.:1384526-74-2Synonyms:EPA(metformin);Timnodonicacid(metformin)分?式:C??H??N?O?分?量:431.61作?靶點(diǎn):EndogenousMetabolite;HistoneDemethylase作?通路:MetabolicEnzyme/Protease;Epigenetics儲(chǔ)存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性EicosapentaenoicAcid(EPA)metformin?種具有?服活性的ω-3長(zhǎng)鏈多不飽和脂酸(ω-3LC-PUFAs)。Eicosapentaenoicacidmetformin具有促進(jìn)腫瘤抑制因CCAAT/增強(qiáng)?結(jié)合蛋?δ(C/EBPδ)重新表達(dá)的DNA去甲化作?。Eicosapentaenoicacidmetformin通過H-RAS內(nèi)含?1CpG島去甲化激活U937??病細(xì)胞中的RAS/ERK/C/EBPβ途徑。Eicosapentaenoicacidmetformin能促進(jìn)?管平滑肌細(xì)胞的松弛和?管舒張。戶使?本產(chǎn)品發(fā)表的科研?獻(xiàn)?GutMicrobes.2022,14(1):2139978.?CancerImmunolRes.2022Dec2;10(12):1542-1558.?Haematologica.2021Feb4.?ProcNatlAcadSciUSA.2021Oct26;118(43):e2104689118.?PharmacolRes.2024May17:107214.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].Martins,J.G.,EPAbutnotDHAappearstoberesponsiblefortheefficacyofomega-3longchainpolyunsaturatedfattyacidsupplementationindepression:evidencefromameta-analysisofrandomizedcontrolledtrials.JAmCollNutr,2009.28(5):p.525-42.[2].Shun-heWang,etal.Endogenousomega-3long-chainfattyacidbiosynthesisfromalpha-linolenicacidisaffectedbysubstratelevels,1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEgeneexpression,andproductinhibition.RSCAdv.,2017,7,40946-40951.[3].MiaozhenPan,etal.Dietaryω-3polyunsaturatedfattyacidsareprotectiveformyopia.ProcNatlAcadSciUSA.2021Oct26;118(43):e2104689118.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;02