Sertaconazole-nitrate-Standard-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemESertaconazolenitrate(Standard)Cat.No.:HY-B0736ARCASNo.:99592-39-9分?式:C??H??Cl?N?O?S分?量:500.78作?靶點(diǎn):Fungal;Autophagy;Apoptosis;p38MAPK;Microtubule/Tubulin作?通路:Anti-infection;Autophagy;Apoptosis;MAPK/ERKPathway;CellCycle/DNADamage;Cytoskeleton儲(chǔ)存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Sertaconazole(nitrate)(Standard)Sertaconazole(nitrate)的分析標(biāo)準(zhǔn)品。本產(chǎn)品?于研究及分析應(yīng)?。Sertaconazolenitrate(FI7056)?種局部?譜的抗真劑，可通過(guò)激活p38-COX-2-PGE2通路來(lái)發(fā)揮抗炎活性。Sertaconazolenitrate也?種微管蛋?抑制劑，具有抗癌細(xì)胞增殖活性，誘導(dǎo)細(xì)胞的凋亡和?噬，還能抑制細(xì)胞的遷移，具有較好的抗癌活性。REFERENCES[1].Carrillo-Mu?ozAJ,etal.In-vitroantifungalactivityofsertaconazole,econazole,andbifonazoleagainstCandidaspp.JAntimicrobChemother.1995Oct;36(4):713-6.[2].SurR,etal.Anti-inflammatoryactivityofsertaconazolenitrateismediatedviaactivationofap38-COX-2-PGE2pathway.JInvestDermatol.2008Feb;128(2):336-44.[3].SebastianJ,etal.SertaconazoleinducedtoxicityinHeLacellsthroughmitoticarrestandinhibitionofmicrotubuleassembly.NaunynSchmiedebergsArchPharmacol.2021Jun;394(6):1231-1249.[4].ZhangW,etal.SertaconazoleprovokesproapoptoticautophagyviastabilizingTRADDinnonsmallcelllungcancercells.MedComm(2020).2021Dec16;2(4):821-837.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax: