Pentoxifylline-Standard-BL-191-Standard-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEPentoxifylline(Standard)Cat.No.:HY-B0715RCASNo.:6493-05-6Synonyms:BL-191(Standard);PTX(Standard);Oxpentifylline(Standard)分?式:C??H??N?O?分?量:278.31作?靶點(diǎn):HIV;Phosphodiesterase(PDE);Autophagy作?通路:Anti-infection;MetabolicEnzyme/Protease;Autophagy儲(chǔ)存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Pentoxifylline(Standard)Pentoxifylline的分析標(biāo)準(zhǔn)品。本產(chǎn)品?于研究及分析應(yīng)?。Pentoxifylline(BL-191)?種?液流變學(xué)改劑。Pentoxifylline?種具有?服活性的，?選擇性的磷酸?酯酶(PDE)抑制劑，具有免疫調(diào)節(jié)、抗炎、?液流變學(xué)改、抗纖溶和抗增殖作?。Pentoxifylline可?于研究周?管疾病、腦?管疾病和其他?些涉及局部微循環(huán)缺陷的疾病[1][2][3]。IC50&TargetPDE[1]體外研究Pentoxifylline(0.1-50mM;24-48hours)inhibitscellproliferationinadose-dependentmanner[3].Pentoxifylline(0.5mM;12-36hours)increasesapoptosisanddecreasesautophagylevelsinMDA-MB-231cells[3].Pentoxifylline(0.5mM;12-36hours)inducesautophagyinMDA-MB-231cells[3].Pentoxifylline(0.5mM;24-48hours)blockscellcycleattheG0/G1phase[3].PentoxifyllineresultsinhighLC3-II/LC3-ratio[3].體內(nèi)研究Pentoxifylline(200mg/kg;i.p.)hasaprotectiveeffectonratswithtransientglobalischemiaandreducescognitiveimpairment[4].?MolCancer.2022Apr27;21(1):106.?JIntegrAgric.2023Feb24.1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE?EurJPharmacol.2023Feb21;175607.?OncolRep.2021Jan22.?JCancerResClinOncol.2023Mar31.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].IffatHassan,etal.Pentoxifyllineanditsapplicationsindermatology.IndianDermatolOnlineJ.2014Oct-Dec;5(4):510–516.[2].AWard,etal.Pentoxifylline.Areviewofitspharmacodynamicandpharmacokineticproperties,anditstherapeuticefficacy.Drugs.1987Jul;34(1):50-97.[3].YessicaCristinaCastellanos-Esparza,etal.Synergisticpromotingeffectsofpentoxifyllineandsimvastatinontheapoptosisoftriple-negativeMDA-MB-231breastcancercells.IntJOncol.2018Apr;52(4):1246-1254.[4].ShabnamMovassaghi,etal.EffectofPentoxifyllineonIschemia-inducedBrainDamageandSpatialMemoryImpairmentinRat.IranJBasicMedSci.2012Sep-Oct;15(5):1083-1090.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuse