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DigitalHealth
Radar2024
Summary
1.DigitalHealth
Radar
OpeningInsights
StartupLonglist
2.Insights
OurShortlist
MarketInsights
AViewtotheFuture
3
5
6
7
11
3.SelectCase
Studies
CharcoNeurotech
Avegen
TaraCares
4.Appendix
Methodology
Glossaryand
References
12
13
14
15
16
DigitalHealthRadar
DigitalHealthRadar2024
OpeningInsights
SinceCOVID,weandourclientshave
observedadiscerniblechangeinhow
healthcareisdeliveredtopatientsglobally.Digitalhealthisseenasatransformational
partofthischangeinhealthcareprovision.Thisisevidencedbyrenewedimpetusinthestartupspacewithinvestmentreaching$3billionin2021.Ourfirstinterviewee,LucyJung,founderandCEOofCharcoNeurotech,notedthistrend,highlightingtheriseinhealthcare-
focusedproductdevelopmentandtechnology.
However,thesituationisnotentirelypositive.In2023investmentdeclinedto$1.1billion,
indicatingthatothereconomicand
geopoliticaldevelopmentsmaybeleading
tovolatility.Factorssuchastheemergenceofopen-accessGenAI,thewarinUkraine,thePalestine-Israelconflict,issuesintheGulfofAden,risinggasprices,andgeneralinflationmayallplayapart.
Pharma’sresponsetodigitalhealthhasbeenmixed.WhilstBiogencloseditsdigitalarm,EliLillyandCompanyreleaseditsowndigital
healthsolution:LillyDirectTMandAstraZenecahastakentheplungetospinoutitsdigital
healthdevelopmentarmintoEvinova,
leadingtomixedsignalsacrosstheboard.UtilisingstartupstosuperchargeinnovationcouldbeawaytobridgethegapforthosecautionaryPharmacompanieswishingtoexpand.
“Whenwestartedin2019,thereweren’tmanypeopleintheproductdevelopmentandtechareathatwerelookingintohealthcare.Therewaslotsofresearch
conceptsbutnotmanycompaniesorsupportinthisspace.I’mexcitedtoseetheimportanceofthisrisingovertheyears.”
LucyJungCo-founder&CEO,CharcoNeurotech
3
DigitalHealthRadar
“Thegeneraltrendistowardspartnership,towardspartneringwithstartups
likeourselvesbecausewecanprovidethedevelopmentcapability,wecanprovidetheplatform.Theydon'tneedtodoallthat.Theydon'tneedtohiresoftwareengineers.TheyneedprojectmanagersorprojectownerswhichisaneasierroletofillinPharma.”
JamieCampbellAssociateDirectorofCommercialPartnerships,Avegen
Inour2023WhitePaper
‘Competingthrough
CustomerValue
’wediscussedhow
partneringbetweenstartupsandpharmacanallowcompaniestogeneratevalueforpatientsandcustomersataquickerpace.ThisviewissomethingJamieCampbell,
AssociateDirectoratAvegen,pointsout,
describingtheefficienciesthatcancomewithemployingexternalexpertise.Digital
healthsolutionscanalsohelptoremove
someofthecostfromproviders,freeingupinvestmenttootherpartsofthehealthcaresystemandenhancingvalueforcustomers.Lookingtothestartupscenemaythereforehelptodiscernthefutureofthisdynamic
space.
Whilstthedigitalhealthstartupmarket
withintheUSiswelldeveloped,withseveralexamplesofunicorns(suchas23andMeasof2015orTempusasof2018),themarket
withinEuropehasnotbeenasfruitful.Thereareseveralpotentialreasonsforstagnation.Theseincludetheuniversalhealthcare
modelscommonlyutilisedinEurope,whichcanmakeprofitabilitymorechallengingandconsequentlylessappealingtoinvestors.
Additionally,Europe'sfragmentednature
resultsinnumeroussmallermarkets,
collectivelytotaling500millionpotential
users,asopposedtoasinglemarketof350millionpotentialusersintheUS.
TherearesomeverygoodexampleswithinEuropeofcompaniesdevelopingbeyondasinglemarket,companies,suchasOwlstoneMedical,havebecomeprofitableand
successfulacrossmultiplemarkets,bridgingthegaptotheUSandglobally.Consideringthesegreenshoots,wehaveanalysedthe
Europeanstartupmarketandhighlightedthekeydevelopments,trendsandexamplesofcompaniesthatweareeagertowatchthathaveinnovativesolutionsorthataremakingwavesinthemarket.Youcanfindoutmore
aboutourmethodology
here
.
4
DigitalHealthRadar
TheDigitalHealthRadar
StartupLonglist2024
Ourlonglistillustratesourinterpretationofthe
dimensionsofthedigitalhealthstartupspace.Displayedaretheuniqueandinnovativeofferingsthathavethe
potentialtotransformpatientcare.
Animportantpointtonoteisthat
telemedicineandmHealthpropositionsareconspicuousbytheirexclusionfromthe
Radar.Thenumberofthesehave
skyrocketedfollowingCOVIDandcontinuestogrow;in2020,250newdigitalhealthappswereaddedtotheappstoreperday1.Duetothescaleofthissector,wehavetherefore
limitedtheirappearanceinourRadartoa
fewspecial-caseexampleswebelievetobetrulyinnovative.ThisincludesMika,anAI-
poweredcompanionforcancerpatientsandcaregivers,BeneTalk,ahabitbuildingapp
forstammeringthatanalysesspeechandprovidesrealtimefeedback.
w5
Insights
OurShortlist
Ourshortlistdepictswhatwebelievetobethepotentialfutureleadersindigitalhealthinnovations.
Ourinterpretationofmarketinsights
Overall,weseefourkeytrendsacrossthestartupmarket:
1.Providinginformationtopatientsandinvestorsfuelssuccess
2.Gatheringinformationandpatientinsightsimproveprospects
3.Companiesaddressingmultipletouchpointsacrossthepatientjourneyshowgreatpotential
4.Thereisagrowingrequirementforevidence-ledDTxandhealthcaresolutions
6
Insights
MarketInsights
1.Providinginformationtopatientsandinvestorsfuelssuccess
Onecriticalobservationwe
gainedfromcyclingthrough574companies,wasthat
thismarketisvast.Tofloatto
thetop,startupsarebenefitingfromusingvalidatedresearchto
differentiatethemselvesand
increasecredibility.There
arenumerousexamplesofthisthroughoutourlonglist.One-waystartupsaredoingthisisbyfocusingon
informationprovisionto
drivepatienteducation,
adherenceanddrivevalueandsuccess.Whathas
becomeofincreasing
importancetopatient
providersandusersisthattheinformationprovidedisaccurateandever
increasinglyactionable.
Acrosstheboard,theresultsareconsistent-evidence-
basedapproachesarekeyforpatientengagement.Thisincludespatientstudies
acrossconditionsand
therapyareas,including
asthma,diabetes3and
hypertension4.Likewise,
studiessuchasTinschertetal.2019showtheimportanceofevidence-based
informationingaining
patienttrustinAIchatbots.
Whilstyoumaybeabletoprovideinformationto
patients,whatcanyoudowiththatinformation?
Wesawasaturationof
digitalappsthatfocusedonbringingpatientstodoctors;however,reducingthe
impactonhealthcare
systemsbypreventative
measuresisincredibly
important,especiallyifwewishtoachievesustainablehealthcaresystems.
Itisthereforeessentialwe
looktoeducation,basedonpeerreviewedinformation,tosupportpatientsin
everythingfromtreatmentchoicetobehavioural
support.Thisisagapseen
by
TaraCares
whoturned
individualizedresearchintomeaningfulinsightsto
informhormonehealthy
ageingforsubscribersofitsMIMOSAplatform.FounderandCEOJyotiSharmaspoketousabouttheimportanceofcenteringscienceintheconversationaroundage-
relatedhealth
Thecompanylooksto
enableitsuserstogaina
bettercontroloftheirbodiesholistically,whichbrings
agencyandinevitablycanreduceimpactonthe
individual,employers,andhealthcaresystems.Healthy
ageingandbetter
understandingofourbodiesandthechangesthattheygothroughasweprogressthroughlifeisofincreasingimportancetopatients(andconsumers).
However,withgreater
evidenceoftencomes
greaterregulatoryoversight.Tocombatsomecompaniesarebeginningtheir
propositionsby
recommendinginformation,slowlybuildingthegreaterscrutinyneededforbuildingamedicaldeviceordigitaltherapeutic.Thismethod
hastheaddedbenefitof
enablingtrustbuildingandcredibilityinthespace.
“Wearelevellingupthescienceforhealthyageing.BypersonalizingsciencebasedonindividualdifferencesforhormonalshiftsandtransitionincludingMenopauseweareshapingthefutureoffemaleworkforgenerationsto
comeanddeliveringahealth-orientedemployee-employercaremodel
JyotiSharmaFounderandCEO,TaraCares
w7
Insights
8
2.Gatheringinformationandpatientinsights
improvesprospects
Ofcourse,thereisadualitytothisinformation.Asmorepatientsbegintousedigitalhealthsolutions,more
informationbasedon
consumptionbecomes
availabletothecompaniesthemselves.LucyJungof
CharcoNeurotech
spoketousaboutsomeofthe
benefitsshefoundfrom
leaningintothisopenand
curiousapproachtopatientstoprovidepivotalinsightsforitsCUE1wearable.Lucy
reflectedonaconversationshe’dhadwithacommitteememberandfriendwhowaslivingwithParkinson’s.He
pointedouttoherthe
difficultiesinconveyingthecompleteanddiverse
strugglesofthediseaseby
lookingpurelyatclinical
data.Oneday,hehad
visitedLondonforadoctor’sappointment.Whilstseatedherealisedhehadbecomeunabletogetup,leftgoingincirclesonthetubeand
unabletomove.He’daskedher:“ifIwasn’tabletomakeonestepthatday,howcanyoumeasurethat?”Those
wordsstuckwithLucyandhaveshapedCharco
Neurotech’sapproachtoitspatients;utiliseclinicaltrialswhilststayingcloseand
curiouswiththepeopletheyaretryingtohelp.
Onahumanlevelthese
insightsareessentialto
rememberthepurposeandimpactofthesedigital
healthsolutionsandprovide
directionforopportunitiesfordevelopment,potentialrisksorareasfordiversification.
Likewise,addingmeaningtoyourdatacancreatebuyinforinvestorsandconsumersalike.
“We'renotlookingtooneanswer.We're
lookingforlotsof
answers…It’snotjustclinicalmeasures
thatareimportant–remembertothink
aboutthepeople”
LucyJungCo-founder&CEO,CharcoNeurotech
Insights
9
3.Companiesaddressingmultipletouchpoints
acrossthepatientjourneyshowgreatpotential
Wheninvestigatingtheperformanceofourlonglistwebegantoseeatrendwithnumerousofferings
reachingfunding,developmentorclinical
milestoneswhenaddressingmultipletouchpointsacrossthepatientjourney.Forexample,wehave
seencompaniessuchasIkerian,withitsRetinAI
platform,supportingclinicalresearchflowsaswellasAIenabledeyediagnosticsanddecisionsupportreachingfundingandpartnershipmilestones.
Wevalueconnectionwith
peopleusingorwaitingtouse
thedevice.Oncetheloopisbroken,innovationsuffers.”
LucyJungCo-founder&CEO,CharcoNeurotech
4.Thereisagrowingrequirementforevidence-ledDTxandhealthcaresolutions
NeedforValidation
TheEuropeanmedicalspaceisarguablyoneofthemostevidence-ledindustriesinthe
world,highlyvettedandhighlyregulated.Itappearsthedigitalhealthspaceiscatchinguptotheestablishedstandardsofthis
industryanditspharmacompanieswhich
holdthewealthandinfluencetosupportnewstartupsuccess.ProducingourRadar,the
shifttowardsinvestmentintechnologies
evidencingtheirclinicalvaluewasapparent;perhapshelpingtheseofferingstostandout
againsttheplethoraofunvalidated
telehealthsolutionsthathavefloodedthemarketinrecentyears.
WhereHCPsandpayersarethecustomer,
clinicalevidenceorpublicationprovides
validationinamarketthatvaluesrobust
scientificapproach.
Avegen
Associate
DirectorofCommercialPartnerships,JamieCampbell,detailedtheneedforevidencetosupportitscloud-hosted,DigitalClinical
Workflows.ThecompanyrecentlyreceivedthegoldawardfromHSJforclinical
partnershipsasitsKlickofferingreducedwaitingtimesfrom6to3monthsand
decreasingmissedappointmentsby41%.6
CurrentChallenges
However,whilstthedemandforevidence
backedhealthcaresolutionsprevails,the
levelofevidencerequiredfordigitalhealthtechnologieswithineachofthesesegments
variesgreatly.Ambiguitywithinthe
requirementsdefinedbyregulatorybodiesremainsachallengeandorganizationsarestartingtopre-emptmorerobustregulatorypositionsinthisarea,leadingtoanincreaseinclinicalvalidationfordigitalhealth
technologies.Eventhosedigitalhealth
technologiesthatarenotregulatedas
medicaldevicesarestartingtocollectdatatoevidenceeffectivenessandbackup
claims.TherecentAIactfromtheEUfurtherimpactshere,theadditionofdataprivacyandusageregulationsforAImakeitmorecomplextogetthedataandinsightneededtoprovidemaximumvaluefornewsolutionsandenablevalidation.
Finally,tothepointaroundregulation,
ensuringcybersecurityhasbeenthoroughlybakedintoanydigitalsolutionthatcontainsdataremainsparamountforfutureor
ongoingsuccess.Anexampleofthisis
RetinAI,anAI-poweredeyediagnosticdatamanagementplatformusedtosupport
clinicalresearchworkflows.Nowboasting20processedclinicalstudies,over40peer
reviewedpublicationstodateanda2023CEMarkingCertificateforDiscoveryasaclassIIadevice.7
Insights
FindingtheSolution
However,whilstourRadarexemplifiesthestandoutsinthemarketcapitalizingon
evidence-ledsolutions,itappearsmanyhavefallenbehind.A2022studyestimatesonly20%ofhealthtechcompanieshavegoodclinicalevidenceandregulatory
filings.8
Ironically,theanswertomanyofthese
hurdlesmightlieinsomehealthtech
companiesfeaturedonourlist.Forexample,TrialBeeisacomprehensiverecruitment,
pre-screeningandconsentsolution
designedtodrivetrialefficienciesthroughscalable,real-worlddataandreal-timeanalytics.9
AnothergreatexampleisuMotif,apatient
engagementplatformforclinicalandpost-marketresearch.Itscasestudieshave
shownbothanincreaseincomplianceandareductionofstudytimelinesby30%,
demonstratingtheexpertiseandfinancial
benefitsofitsservices.10SanoGeneticsalso
offerpatientsearch,screeningand
engagementservicesinwhattheycall‘a(chǎn)
completecircle’platformthatutilisesDNAanalysistosuggestclinicaltrialstoviablecandidates.11Theseofferingsmaythereforehelptogeneraterobustevidencewith
greatereaseandspeed
“Oneplacemanydigitalhealthcompaniesfalldownisthattheydon’tcollectanyclinicalevidence.Webelieveit’sreallyimportanttobackupourclaimswithevidenceandoutcomes.”
JamieCampbellAssociateDirectorofCommercialPartnerships,Avegen
10
Insights
AViewtotheFuture
Regulatorsmustalsocatchuptothese
changes.AsLucyJungstates,regulators
must,andareadaptingtotheevolveddigitalcarepathway.Anexampleofthiscanbe
seeninGermanywiththeintroductionof
DiGAin2019.ThisinitiativeincludesaFast
Trackprocessforstreamliningformal
approvalsandlistingsofdigitalhealthcareapplications,enablingfastermarketentry.
DiGAissymptomaticofthedemandand
competitionfacedinthisspacewithstartupsneedingtoofferinnovativeandeffective
solutionstomeettheDiGAdirectory
criteria.12
ChangescanbeseenintherestofEuropetoo,withtheEuropeanHealthDataSpace(EHDS)proposingnewregulationsthat
mandatedatasharinginthehealthcarespace,implyinggreateraccesstohealthdata.
Alongsidethesenewtechnologiescomesaneedforcompaniestoadapttheirinternalgovernance,ensuringcompliancewithnewdirectivessuchastheAILiabilityDirective
(AILD)andthepreviouslymentionedAIAct.
Startupsandpharmaalikemustprepareforthechallengesofassessingandelevatingriskmanagement,traceabilityand
cybersecutiry.13
“Technology'sonething,regulations
andtrialsarestilltraditional
pathwaysofpharmacological
process(phase1/2/3)whendigitalcareisaquitedifferentpathway.Ifeelpositivethatregulatorsare
realisingthisandadaptingand
pushingoutregulations.Thisisa
challengingareabutit’samazingtoseepeoplearemoreinterestedandfoundersaregettinginvolved.I’m
hopeful.There’salottodoandwe
needtocollaborateacrossindustries”
LucyJungCo-founder&CEO,CharcoNeurotech
Withdynamismandnewplayersalwayscomingtothe
market,thedigitalhealthstartuplandscapeinEurope
remainsofcriticalinteresttohealthcaresystemsand
pharma.Welookforwardtoseeinghowthestartupmarketadaptsandchangesinthecomingmonthsandyearsandtolearnwhatnewdevelopmentsourshortlistcompanieshaveinstore.
11
CaseStudies
SelectCaseStudies
CharcoNeurotech
Mission
Lucytellsus:mypersonalgoalis"bringingbacksmilestopeoplewithParkinson’s".It'sthedevice,theservice.It'sthetotalthat
makesabigdifference.We'renotadevicecompany,we'reacompanythatcaresforpeople.Wewanttohelpotherpeoplewithmovementdisordersandneurological
conditions.
CEO
LucyJung
Website
HQ
UK
Category
Wearable/DigitalTherapeutic
TherapyArea
Parkinson’swithafocusonstiffness,slownessandgait
Funding
Seedfunded.LastinvestmentNovember16th,2021,of£7.4m
Tech
TheCUE1isanon-invasive,wearable,
medicaldeviceforpeoplewithParkinson’s,toimprovemovementandqualityoflife
Purpose
Theprincipleofferingofthecompanystems
from19thcenturyFrenchneurologist
ProfessorJean-MartinCharcotwhofoundhispatients’symptomsdramaticallyimprovedwhentheytravelledtohimbycarriage.Itwassoonsurmisedthevibrationsofthecarriagerideseemedtooffertherapeuticbenefit.In
modernday,thisideahassincebeen
researchedwithstudiesfindingvibration
stimulationtoresultinimprovementinstiffness,slownessandgaitamongothersymptoms.
Testing
Pilottestshaveseenparticipantswith
Parkinson’simprovetheirMDS-UPDRSscoresbyanaverageof9.3points,3timesthelevelconsideredclinicallysignificant.100%of
participantsreportedthattheywouldwanttousethedeviceagain.Continuingtostudy–3,200peoplecurrentlyusingthedevice
andbeingstudiedforthey’reusingandthesymptomcategory.
w12
CaseStudies
Avegen
CEO
Dr.NayanKalnad
Website
HQ
UK
Category
PatientSupport
TherapyArea
Longtermconditions
Funding
PrivatelyfundedwithintentionforseriesAfunding
Tech
Customizabledigitalhealthplatform
Purpose
ClinicianNayanKalnadandNeerajApte
createdAvegenin2015followinga
successfulandeducationalexperiencein
Pharmaandtechwiththemissionofmakingtheworldahealthierplace.Avegenisdrivenbypatientinsightsandcutting-edge
research
Testing
Avegenhasconductedmultiplestudiesonitsappstoensureitsclaimsarebackedup
withevidence.Thisincludesapublished
studyforHeartHealthfindinga51%reductionin6-monthreadmissionsanda30%increaseinclinicalcapability.ItsrandomisedclinicaltrialforitsTogetherforHerappfounda90%increaseinhealthliteracyanda142%
increaseindietarydiversity.Italsotracked1.9millioninstalls,positioningtheappinIndia’sTop3forparentingatthetimeofthestudy.
w13
CaseStudies
TaraCares
Mission
Levellingupthescienceforhealthyageing
Tech
ResponsibleAI-baseddigitalsupporttoolandeducation
Purpose
Equippingeveryhumantomastertheir
uniquehealthyageingjourneywith
personalisedresearchandhealthinsights
(withmenopausenavigationasaninitialuse
case)bytacklingmisinformation,
misdiagnosis,andmismanagement.
Integratingacademicresearch,clinicalexcellenceandcomputationalscience.
Product
MIMOSA,themodularplatformdevelopedby
TaraCares,isrevolutionizingtheway
corporatesaddressmenopause.Withits
evidence-led,science-backedapproach,MIMOSAofferscontinualaccesstoresearch,andscientificevidencetailoredfortheuser.
Fromtracing29hormonalhealth
determinantstopreparingformedicalappointments,theplatformprovidesa
comprehensivesolutionforwomen
navigatingmenopause.Morethanjustatool,MIMOSArepresentsashiftinmindset.It
encouragesorganizationstomovebeyondsuperficialmenopausepoliciesandinvestinscience-backed,actionablestrategies.Byunderstandingtheirmenopause
demographicandindividualpainpoints,
companiescancreateamoreinclusive,
supportiveworkenvironment.Indoingso,
theynotonlyretainvaluabletalentbutalsofosteracultureofunderstandingand
empathy.MIMOSAlookstoavoidthetrapsofsymptomtrackingandhormonetestingto
provideholisticsupportandinformation.Inarevolutionaryground-breakingmovethe
companyhasreleased,MIMI(MenopauseInformationandManagementInterface)
afterayear-longBetatestingwithcliniciansfromtheUS,UKandIndia.Availablefor
CEO
JyotiSharma
Website
mymimosa.uk
HQ
UK
Category
PatientEmpowerment(B2B
SaaS,HRTechforMenopauseHealthliteracyandintegratedemployeewellbeing)
TherapyArea
Healthyageingandhormonalshifts
Funding
Privatelyfunded
premiumsubscribersofMIMOSAplatform,
MIMIistheworld'sfirstResponsibleAIco-
pilot.Leveragingcutting-edgeresponsibleAIandadeepunderstandingofhumanhealth,MIMIaimstobecomeanindispensabletoolforwomenandfemaleindividualsofallagesseekingtooptimisetheirhormonalwellbeingandhealthspan,frompubertytopost-
menopause.MIMOSAisavailablein20+countriesonAndroidandiOSthroughemployerpaidsubscriptionmodel.
w14
Appendix
Methodology
ThiseditionoftheDigitalHealthRadaris
basedondataobservedoverthepastyear.WeanalysedbothOpen-SourceIntelligence(OSINT)andconductedqualitativeinterviewstoproducethisRadar,incorporatingourownopinionsandsubjectmatterexpertise.
Depictedare84longlistedinnovative,
Europeanstartupswehaveattemptedtosegmentintotheprimaryfunctiontheirsolutionsappeartooffer.
However,weknowtherearemanymoredigitalhealthinnovatorsintheEuropean
ecosystemthatweneedtohearfrom.Ifyouareinterestedinbeinginvolvedinthenextedition,pleasegetintouch[link].
Inoursearchwereviewed33funds,
researched574companies,longlisted88,
shortlisted16andinterviewed3ofthemost
excitingmarketinnovatorsintheEuropeanDigitalHealthspace(inouropinionof
course).Theirofferingsrangedfromdigitaltherapeuticstowearablesandutilised
techniquesrangingfromAR,VRthroughtoAIandbeyond.
OurSelectionCriteria:
?BasedinEuropebutcouldhaveoperationsinotherpartsoftheworld
?Itsbusinessmodelcentersaroundinnovationsinthedigitalhealthspace
?Definedasastartup
w15
Appendix
GlossaryandReferences
Glossary
DiGAreferstoDigitale
GesundheitsanwendungeninGermanor
digitalhealthcareapplications.Theseare
applicationsformallyapprovedandlistedin
theDiGAdirectory,followingtheregulationsoutlinedintheDigitalHealthcareAct
(Digitale-Versorgung-Gesetz,DVG).
DigitalTherapeutics(DTx)ultimately
enhancespatientoutcomesthrough
combiningtechnologyandmedical
expertise.Regardingtreatmentplanningandmanagement,DTxisenhancedby
leveragingtechnologyforpersonalised
suggestionsandrecommendations,goingbeyondprocessessuchasautomationorsymptomtracking.ItincludesHCP
interactions,recommendations,
interpretationofresultsandtargeted
interventionsthatutilizeexpertise.Withmonitoring,thisisautomated,involvingpatientinteractionsandtargetingand
communicatingdirectlyorindirectlywiththeHCP,forexampleviareports.
mHealthreferstomobilehealth,ageneraltermfortheuseofmobilephonesandotherwirelesstechnologyinmedicalcare.
mHealthhasanarrayofusesincludingeducationofpreventativehealthcare
services,diseasesurveillance,treatmentsupport,epidemic
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