微生物學(xué)課件個(gè)論腸道病毒

腸道病毒與

輪狀病毒中醫(yī)七年制腸道病毒新型腸道病毒內(nèi)容Contents脊髓灰質(zhì)炎病毒輪狀病毒新型腸道病毒小結(jié)12433學(xué)習(xí)要求掌握1、脊髓灰質(zhì)炎病毒的致病性2、特異性預(yù)防（劑型）自學(xué)柯薩奇病毒熟悉1、脊髓灰質(zhì)炎病毒抵抗力、感染類型2、新型腸道病毒自學(xué)?？刹《舅伎碱}為什么預(yù)防脊髓灰質(zhì)炎的預(yù)防疫苗選用口服制劑？脊髓灰質(zhì)炎病毒poliovirus結(jié)構(gòu)Poliovirus生物學(xué)特征形態(tài)與大小病毒抵抗力在污水和糞便中可活數(shù)月食品中可保存數(shù)周不易被胃酸或膽汁滅活對(duì)氧化劑敏感56。C30min被滅活致病性傳染源：病人或無(wú)癥狀攜帶者傳染方式：糞-口途徑致病機(jī)理二、致病性病毒咽部、腸壁淋巴組織入血流第1次病毒血癥入全身淋巴組織再次入血流第2次病毒血癥中樞神經(jīng)系統(tǒng)

埃及第十八朝的這塊石碑可能是脊髓灰質(zhì)炎病例的最早記載。歷史小兒麻痹癥感染類型人群中絕大多數(shù)為隱性感染或輕型感染顯性感染引起麻痹者僅為顯性感染的0.1%-1%頓挫感染免疫性SIgA：清除腸道內(nèi)病毒，阻止病毒入血IgM,IgG:阻斷血流中病毒向中樞神經(jīng)系統(tǒng)擴(kuò)散感染后獲得對(duì)同型病毒較牢固的免疫力預(yù)防口服脊髓灰質(zhì)炎減毒活疫苗糖丸(1957年發(fā)明）

OralvaccinationwithlivevaccineVaccinationprogramshaveeradicateditfromtheWesternworldandpromisetoeliminateitglobally

DrAlberSabin我國(guó)疫苗的生產(chǎn)顧方舟教授向周恩來(lái)總理匯報(bào)脊髓灰質(zhì)炎病毒疫苗研究和生產(chǎn)情況ORALVACCINE51周年1957今天疫苗使用的效果輪狀病毒看圖獲得什么信息？形態(tài)（為什么叫輪狀病毒？）核心為dsRNA，外有雙層衣殼，內(nèi)外兩層呈放射狀排列輪狀病毒分組：A、B、C組：可引起人、動(dòng)物腹瀉，最常見(jiàn)A組(有稱為小兒輪狀病毒）D-G組：僅引起動(dòng)物腹瀉A組抵抗力：耐乙醚、弱酸室溫中傳染性可保持7個(gè)月-20。C長(zhǎng)期保存A組輪狀病毒所致疾?。簨胗變河绕淝锒炯毙晕改c炎傳播途徑：糞-口途徑機(jī)理：病毒在十二指腸粘膜細(xì)胞中增殖影響腸道對(duì)水、鹽的正常吸收腹瀉（糞便綠或白色），常伴發(fā)熱，嚴(yán)重者可出現(xiàn)脫水或酸中毒新型腸道病毒？？68697170721969年以來(lái)分離鑒定的腸道病毒HotTip新型腸道病毒71引起中樞神經(jīng)系統(tǒng)感染世界性分布腦炎，腦膜炎手足口病（日本，瑞士）新型腸道病毒70感染眼結(jié)膜急性出血性結(jié)膜炎“紅眼病”結(jié)膜下出血接觸傳染紅眼病

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