審稿意見修回

\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\REQUESTFORREVISIONFeb18201512:10PMRE:MD-D-15-00193,entitled"Majorperioperativecomplicationsinlaparoscopicspleen-preservingtotalgastrectomyforgastriccancer:perspectivesfromahigh-volumecenter"PleasesubmittherevisedmanuscriptviaEditorialManagerbyApr01201511:59PM.COMMENTSTOAUTHOR:Wereadwithinterestyoursubmission.Despitetheeaseofusingthemodeltopredictoutcomes,themodelneedsfurthervalidationandthisshouldbeclearlystatedasalimitationinthemanuscript.Moreover,whywastheNo.10LNmetastasisnotincludedinthemodeldespiteitsstatisticalsignificance?一點應(yīng)該在文章的“不足”部分更清晰的闡釋。另外，NO.10淋巴結(jié)轉(zhuǎn)移是影響CommentstoAuthorReviewer#1:TheinclusioncriteriaforLSPTGarefarbeyondtheJGCAguidelinesforgastriccancertreatment.Bynow,laparoscopicgastrectomyiswellacceptedamongearlydiseases.However,forlocallyadvancedgastriccancer,laparoscopicgastrectomyisonlyconsideredinaprospectiveinvestigation.Additionally,thereisnovalidationforapredictionmodelinthisstudy.Reviewer1:行腹腔鏡保脾淋巴清掃(LSPTG)JGCA的治療指文中的納入和排除標準：Theinclusioncriteriawereasfollows:tumorshadtobelocatedintheuppertwo-thirdsofthestomachortheentirestomach;andpreoperativeevaluationsofthedepthoftumorinvasionhadtoshowthatthetumorwasconfinedtothemuscular(T2)orsubserosallayer(T3).Patientswithdistantmetastasesorobviousserosalcancerinvolvementatthetimeofpreoperativeexaminationwereexcludedfromthisstudy.Reviewer#2:Paperlookingattheperioperativecomplicationsassociatedwithsplenicpreservinglaparoscopictotalgastrectomyforcancerandaproposedscoringsystemforpredictionofmajorcomplications.SomeItisuncertainwhattheutilityofthescoringsystemis.Aretheauthorsproposingthatthesepatientsshouldnothavealaparoscopicprocedurebutanopen.Aretheyproposingthatthespleenshouldberemovedinthesepatients.clarificationwouldbeMostoftheconcernsregardingsplenicpreservationareoncologicalnottechnical.Thisremainscontroversialandiscurrentlyunderinvestigationwithresultsduesoon(ref4)TheabstractandintroductioninparticularshouldnotetheoncologicalissuesconcerningsplenicpreservationThesecondsentenceintheintroductioniscontroversialandnotbackedbyevidence.Itwouldbebettertonotethatmultimodalitytherapyisacceptedasthemosteffectivecurativetreatmentofwhichsurgeryisanessentialpart前言第二句“SurgicaltreatmentiswidelyacceptedasthemosteffectivestrategyforisacceptedasthemosteffectivecurativetreatmentofwhichsurgeryisanessentialItisnotedthatTstagingofthetumoursoccurredpreoperatively.AsEUSwasnotmentionedaspartoftheirpreoperativeworkup,howwasaccurateTstagingdeterminedpreoperatively.SimilarlyasT3tumourswereincludedinthestudy,didthesepatientshaveneoadjuventtherapypriortosurgeryandifsodidthisaffectoutcomeThereisnomentionofpreoperativelymphnodestaging.Werepatientswithpositivelymphnodes(bywhateverstagingcriteria)includedinthestudy.IfsodidtheyhaveneoadjuvanttherapyanddidthishaveanyinfluenceonoutcomeItisnotedthatpatientswere"allowedtoselect"thetypeofoperation.Wasthisopenvlaparoscopic,Wasitsplenicpreservinglaparoscopicvspleenremovedlaparoscopic.Thisneedstobeclarified保脾vs腹腔鏡切脾？Ifpatientshadopenorspleenremovedlaparoscopicprocedures,whatweretheirratesofcomplications.AlthoughitisstatedthatLNdissectionofstation10occurred,nowhereinthestudydoesitmentionthenumberoflymphnodesremvedfromthisstationwiththisWasthereanycorrelationbetweenthenumberoflymphnodesremovedandtheincidenceofcomplications.Thebaldstatementismadethatpatientspreferlaparoscopicsurgerybecauseofitsadvantages.WouldtheauthorspleaseoutlinetheseadvantageswithreferencesEditorialFormatting（格式要求-Titlepage:Besurethetitlepagelistsallauthornames,degrees,and-Title:Besurethetitleincludesanyspecifictermsasdirectedinthereportingguidelinesforyourtypeofarticle(forexample,"casereport"shouldbeinthetitleofaCARE-compliantarticle).Thefollowingguidelinesspecifytermsthatshouldbeinthetitle:CARE,CHEERS,CONSORT,PRISMA.-Abstract:Besuretouseastructuredabstract,withheadings.UsethespecificheadingslistedintheguidelineschecklistifyourreportisbasedontheCARE,CHEERS,CONSORT,orPRISMAguidelines.-Listofabbreviations:Ifnotalreadyincluded,pleaseincludealistofabbreviationsusedinthetextaspartofthemanuscripttextfilefollowingthetitlepage.Useabbreviationssparinglyinthetext,andspellthemoutthefirsttimeyouusethem.Abbreviationsusedintablesshouldbespelledoutatthebottomofthetable.-Ethicalreview,Methodssection:Ifnotalreadyincluded,pleasestateintheMethodssectionthatanethicscommitteeorinstitutionalreviewboardapprovedthestudy,andlisttheboard'sname.Ifethicalapprovalwaswaivedornotnecessary,pleasestatethereason.Ifthestudyinvolvespatientconsent,stateexplicitlythatinformedconsentwasorwasnotgiven,andstatethereasonifnotgiven.-Funding/ConflictofInterestinformation:ListanysourceoffundingoranythingthatcouldbeperceivedasaconflictofinterestintheAcknowledgmentssection.-Acknowledgments:IfyoulistanyonebynameintheAcknowledgmentssection,pleaseconfirmthatthepersongivespermissiontobenamed.-LicensetoPublish:Ifnotalreadysu