間質(zhì)干細(xì)胞和急性肺損傷課件

MesenchymalstemCellsandAcuteLungInjury間質(zhì)干細(xì)胞及急性肺損傷Mesenchymalstem1ARDSwasfirstrecognizedinthe1960s1asaclinicalsyndromeofsevereacuterespiratofailurepresentingwithhypoxemiaandbilateralpulmonaryinfiltrates,mostofteninthesetofpneumonia,sepsis,ormajortrauma●ARDs最初在1960年,被人們認(rèn)識(shí)為嚴(yán)重急性呼吸衰竭的臨床綜合征●血氧不足和雙邊肺浸潤(rùn),通常繼發(fā)于肺炎、敗血癥、或嚴(yán)重的的創(chuàng)傷ARDSwasfirstrecognizedint2distinctionbe(ALI)andARDSrelatestotheseverlendothelialinjury,alveolarepithelialitheaccumulationofprotein-richld、celu|ardebri急性肺損傷(AL)和ARDS的區(qū)別主要指血氧不足嚴(yán)重程度,前者有PaO2/|O2小于300后者PaO2O2不足200;●AL/ARDS的發(fā)病機(jī)制涉及肺血管內(nèi)皮損傷,肺泡上皮損傷,富含蛋白質(zhì)液體的增加和肺泡腔內(nèi)的細(xì)胞殘骸distinctionbe3流行病學(xué)2019年,大約200000名患者在美國發(fā)展為AL|/ARDS,估計(jì)有40%的死亡率采用肺保護(hù)性通氣時(shí)代,死亡率下降大約25%In2019,approximately200,000ptsintheUnitedStatesALI/ARDS,withanestimatedmortalityof40%Intheeraoflungprotectiveventilation,mortalityhasdeclinedtoapproximately25%流行病學(xué)4大量的臨床試驗(yàn),藥物治療吸入表面活性劑(inhaledsurfactant氧化氮(nitricoxide)、前列環(huán)素(prostacyclins),糖皮質(zhì)激素(glucocorticoids),抗氧化劑(antioxidants),酮康唑(ketoconazole)并非AL治療標(biāo)準(zhǔn);●ALI肺泡的病理生理,任何單一分」不可能逆轉(zhuǎn)綜合癥的過程,使臨床獲益:reversethecourseofthissyndrome,providesubstantialclinicalbenefit大量的臨床試驗(yàn),藥物治療吸入表面活性劑(inhaled5間質(zhì)干細(xì)胞和急性肺損傷課件6間質(zhì)干細(xì)胞和急性肺損傷課件7間質(zhì)干細(xì)胞和急性肺損傷課件8間質(zhì)干細(xì)胞和急性肺損傷課件9間質(zhì)干細(xì)胞和急性肺損傷課件10間質(zhì)干細(xì)胞和急性肺損傷課件11間質(zhì)干細(xì)胞和急性肺損傷課件12間質(zhì)干細(xì)胞和急性肺損傷課件13間質(zhì)干細(xì)胞和急性肺損傷課件14間質(zhì)干細(xì)胞和急性肺損傷課件15間質(zhì)干細(xì)胞和急性肺損傷課件16間質(zhì)干細(xì)胞和急性肺損傷課件17間質(zhì)干細(xì)胞和急性肺損傷課件18間質(zhì)干細(xì)胞和急性肺損傷課件19間質(zhì)干細(xì)胞和急性肺損傷課件20間質(zhì)干細(xì)胞和急性肺損傷課件21間質(zhì)干細(xì)胞和急性肺損傷課件22間質(zhì)干細(xì)胞和急性肺損傷課件23間質(zhì)干細(xì)胞和急性肺損傷課件24間質(zhì)干細(xì)胞和急性肺損傷課件25間質(zhì)干細(xì)胞和急性肺損傷課件26間質(zhì)干細(xì)胞和急性肺損傷課件27間質(zhì)干細(xì)胞和急性肺損傷課件28間質(zhì)干細(xì)胞和急性肺損傷課件29間質(zhì)干細(xì)胞和急性肺損傷課件30間質(zhì)干細(xì)胞和急性肺損傷課件31間質(zhì)干細(xì)胞和急性肺損傷課件32間質(zhì)干細(xì)胞和急性肺損傷課件33間質(zhì)干細(xì)胞和急性肺損傷課件34間質(zhì)干細(xì)胞和急性肺損傷課件35間質(zhì)干細(xì)胞和急性肺損傷課件36間質(zhì)干細(xì)胞和急性肺損傷課件37間質(zhì)干細(xì)胞和急性肺損傷課件38間質(zhì)干細(xì)胞和急性肺損傷課件39間質(zhì)干細(xì)胞和急性肺損傷課件40間質(zhì)干細(xì)胞和急性肺損傷課件41間質(zhì)干細(xì)胞和急性肺損傷課件42間質(zhì)干細(xì)胞和急性肺損傷課件43間質(zhì)干細(xì)胞和急性肺損傷課件44間質(zhì)干細(xì)胞和急性肺損傷課件45間質(zhì)干細(xì)胞和急性肺損傷課件46間質(zhì)干細(xì)胞和急性肺損傷課件47間質(zhì)干細(xì)胞和急性肺損傷課件48間質(zhì)干細(xì)胞和急性肺損傷課件49間質(zhì)干細(xì)胞和急性肺損傷課件50間質(zhì)干細(xì)胞和急性肺損傷課件51間質(zhì)干細(xì)胞和急性肺損傷課件52間質(zhì)干細(xì)胞和急性肺損傷課件53間質(zhì)干細(xì)胞和急性肺損傷