實驗室常用化療藥物

1紫杉醇(paclitaxol)分子式：C47H51NO14分子量：853.92CAS號：33069-62-4藥理：促進微管聚合和穩(wěn)定已聚合的微管，抑制有絲分裂。關鍵詞：tubulinbinding，mitosisinhibition代表文獻： WallME.Camptothecinandtaxol:discoverytoclinic--thirteenthBruceF.CainMemorialAwardLecture.Cancerresearch.1995,55(4):753-60.全文鏈接：/pubmed/78507852多烯紫杉醇(Docetaxel)分子式：C43H53NOm分子量：807.88CAS號：114977-28-5

關鍵詞：microtubulesbinding,stabilizedmicrotubles,關鍵詞：microtubulesapoptosis代表文獻：YvonAM,WadsworthP,JordanMA(April1999).”TaxolSuppressesDynamicsofIndividualMicrotubulesinLivingHumanTumorCell.”Mol.Biol.Cell10(4):947-59.3阿霉素(Doxorubicin/Adriamycin)分子式:C27H29NO11分子式:C27H29NO11分子量:579.99CAS號:23214-92-8關鍵詞:代表文獻:關鍵詞:代表文獻:DNAintercalating,macromolecularbiosynthesisinhibitionMomparlerRL,KaronM,SiegelSE,AvilaF(August1976)"EffectofadriamycinonDNA,RNA,andproteinsynthesisincell-freesystemsandintactcells.CancerRes36(8):2891-5.4毗柔比星(Pirarubicin)分子式：c32h37noi2分子量：627.63CAS號：72496-41-4關鍵詞：intercalating,DNAandRNAsynthesisinhibition,topoisomeraseIIenzymeinhibition文獻：ZhengSE,Pirarubicininhibitsmultidrug-resistantosteosarcomacellproliferationthroughinductionofG(2)/Mphasecellcyclearrest.ActaPharmacolSin.2012,5網(wǎng)址：/pubmed/225807405 5-氟尿嘧啶(5-Flurouracil)分子式：C4H3FN2O2分子量：130.08CAS號：51-21-8X"關鍵詞：suicideinhibitor,thymidylatesynthaseinhibition文獻：LongleyDB,HarkinDP,JohnstonPG(May2003).”5-fluorouracil:mechanismsofactionandclinicalstrategies”.Nat.Rev.Cancer3(5):

330-8.doi:10.1038/nrc10746鹽酸伊立替康(IrinotecanHydrochloride)分子式：C33H38N4O6-HCI-3H2°分子量：677.19CAS號：100286-90-6關鍵詞：topoisomeraseIenzymeinhibition文獻:O'DwyerPJ,CatalanoRB(October2006).”Uridinediphosphateglucuronosyltransferase(UGT)1A1andirinotecan:practicalpharmacogenomicsarrivesincancertherapy"J.Clin.Onc(24(28):4534-8.doi:10.1200/JCO.2006.07.30317索拉菲尼(sorafenib)分子式：CHClFNO116 343分子量：464.825CAQ號? zHHCAS號：284461-73-0HH°T...文獻:關鍵詞：tyrosineproteinkinasesinhibition,Rafkinasesinhibition文獻:KeatingGM,SantoroA.(2009).”Sorafenib:AReviewofitsUsein

AdvancedHepatocellularCarcinoma"Drugs69(2):223240.doi:10.2165/00003495-200969020-000068替尼泊苷(Teniposide)分子式：C32H32O13S分子量：656.655CAS號:CAS號:29767-20-2'關鍵詞DNAandDNA-proteincross-linksbreak,關鍵詞topoisomeraseIIenzymeinhibition文獻:AnejaR,Multidrugresistance-associatedprotein-overexpressingteniposide-resistanthumanlymphomasundergoapoptosisbyatubulin-bindingagent.CancerRes.2008網(wǎng)址：/pubmed/183166149舒尼替尼(Sunitinib)分子式：C22H27FN4O2分子量：398.474CAS號：341031-54-7關鍵詞:關鍵詞:文獻:multiplerecepto