人與動(dòng)物及各類動(dòng)物間藥物劑量的換算方法

#動(dòng)物種類Meeh-Rubner公式的K值體重（kg）體表面積（m2）mg/kg-mg/m2轉(zhuǎn)移因子每kg體重占有體面積相對比值小白9.10.0180.00662.9鼠0.020.00673.0粗略值31.00.0220.00713.1(0.02kg)0.0240.00763.2大白9.10.100.01965.1鼠0.150.02575.8粗略值60.470.200.03116.4(0.20kg)0.250.07616.9豚鼠9.80.300.04396.80.400.05327.5粗略值80.400.500.06178.1(0.40kg)0.600.06978.6家兔10.11.500.132311.30.242.000.160812.4粗略值12(2.0kg)2.500.186013.4貓9.02.000.157112.70.222.500.132413.7粗略值14(2.5kg)3.000.205914.6狗11.25.000.327515.30.1610.000.519919.2粗略值19(10.0kg)15.000.681222.0猴11.82.000.187810.70.24粗略值12(3.0kg)

3.004.000.24550.297312.213.5人10.640.001.239832.20.0850.001.438634.8粗略值35(50.0kg)60.001.624636.9表2人和動(dòng)物間按體表面積折算的等效劑量比值表小白鼠(20g)大白鼠(200g)豚鼠(400g)家兔(1.5kg)貓(2.0kg)猴(4.0kg)狗(12kg)人(70kg)小白鼠(20g)1.07.012.2527.829.764.1124.2378.9大白鼠(200g)0.141.01.743.94.29.217.856.0豚鼠(400g)0.080.571.02.252.45.24.231.5家兔(1.5kg)0.040.250.441.01.082.44.514.2貓(2.0kg)0.030.230.410.921.02.24.113.0猴(4.0kg)0.0160.110.190.420.451.01.96.1狗(12kg)0.0080.060.100.220.230.521.08.1人(70kg)0.00260.0180.0310.070.0780.160.821.0(5)按人與各種動(dòng)物以及各種動(dòng)物之間用藥劑量換算已知A種動(dòng)物每kg體重用藥量，欲估算B種動(dòng)物每kg體重用藥劑量時(shí)，可先查第422頁表3,找出折算系數(shù)(W),再按下式計(jì)B種動(dòng)物的劑量(mg/kg)=WxA種動(dòng)物的劑量(mg/kg)例如，已知某藥對小鼠的最大耐受量為20mg/kg(20g小鼠用0.4mg)，需折算為家兔量。查A種動(dòng)物為小鼠，B種動(dòng)物為兔，交叉點(diǎn)為折算系數(shù)W=0.37,故家兔用藥量為0.37x20mg/kg=7.4mg/kg,1.5kg家兔用藥量為ll.lmg。表3動(dòng)物與人體的每公斤體重劑量折算系數(shù)表折算系數(shù)WA組動(dòng)物或成人小鼠0.02kg大鼠0.2kg豚鼠0.4kg兔1.5kg貓2kg犬12kg成人60kgB種動(dòng)物或成人小鼠20g1.01.61.62.73.24.89.01大鼠0.2kg0.71.01.141.882.33.66.25豚鼠0.4kg0.610.871.01.652.053.05.55兔1.5kg0.370.520.61.01.231.762.30貓2.0kg0.300.420.480.811.