catosal科特壯犬貓疾病支持治療藥物演示文稿

catosal科特壯犬貓疾病支持治療藥物演示文稿現(xiàn)在是1頁\一共有31頁\編輯于星期日支持治療支持治療是指與特異性療法配合的附加治療,它可以縮短犬貓疾病的康復時間！現(xiàn)在是2頁\一共有31頁\編輯于星期日支持治療支持治療是指與特異性療法配合的附加治療,它可以縮短犬貓疾病的康復時間！現(xiàn)在是3頁\一共有31頁\編輯于星期日支持治療對犬貓的重要性

一般來說，疾病會降低犬貓新陳代謝機能，而新陳代謝機能降低又會延緩犬貓的康復。臨床上特異性治療不會恢復患病犬貓的新陳代謝機能。所以促進新陳代謝的支持治療性藥物會明顯促進患病寵物的康復?，F(xiàn)在是4頁\一共有31頁\編輯于星期日患病犬貓需要額外的能量來幫助疾病康復總結(jié)簡而言之:患病動物需要更多的能量:正常的身體功能需要從疾病中快速康復

現(xiàn)在是5頁\一共有31頁\編輯于星期日支持治療形式平衡營養(yǎng)充足休息注意管理增加多種維生素和礦物質(zhì)保護肝臟等現(xiàn)在是6頁\一共有31頁\編輯于星期日ATP+H2O ADP+HPO4ENERGY脂類和糖類最終利用的形式(ATP)ATP變成ADP并釋放細胞利用的能量(如:提供給肌肉細胞)能量的利用方式現(xiàn)在是7頁\一共有31頁\編輯于星期日能量–重要的因素整個新陳代謝過程關(guān)鍵因素是磷元素的代謝磷元素在AMP-ADP-ATP循環(huán)后,有部分會流失掉理論上,磷元素加入到ADP分子中是提供能量儲備的最好方式現(xiàn)在是8頁\一共有31頁\編輯于星期日能量–理想的支持治療磷會流失,需要不斷補充提供含能量儲備的磷能幫助細胞更好的工作!隨著能量需求的增加,富含能量的磷混合物可以滿足新陳代謝的需求現(xiàn)在是9頁\一共有31頁\編輯于星期日現(xiàn)在是10頁\一共有31頁\編輯于星期日CATOSAL就是答案每ml含量:布他磷 100.00mg VitB12 0.05mg Methylparaben 1.00mgPhosphoruscontent:17.3mg/ml提供磷元素提供維生素其他作用成分磷含量:17.3mg/mlCatosal–疾病支持治療的關(guān)鍵現(xiàn)在是11頁\一共有31頁\編輯于星期日科特壯的成分布他磷

有機磷酸無味的白色晶體VB12ButaphosphaneVitaminB12+ThePowerofPink現(xiàn)在是12頁\一共有31頁\編輯于星期日科特壯的成分布他磷無味的白色晶體作用機理通過促進ADP-ATP循環(huán)，促進機體能量代謝。促進機體的合成代謝過程。激活犬貓機體非特異性免疫反應(yīng)恢復疲勞肌肉功能?，F(xiàn)在是13頁\一共有31頁\編輯于星期日緩解應(yīng)激/降低激素水平DeGrootJ.,vanDerWerfJ.,vanReenenC.,SchuurmanT.,SchmidtB.(2003):Theeffectofbutafosfan(componentofCatosal)onpsychosocialstressinpigs.J.Vet.Pharmacol.Therap.26(Suppl.1),222-223.VanderStaayJ.,DeGrootJ.,SchmidtB.,SchuurmanT.(2006):EffectsofCatosalonthephysiologicalandbehavioralresponsetosocialstressinpiglets.Proceedingsofthe19thIPVSCongress,Copenhagen,Denmark,Volume2.SimonF(1990):Studyonstressreducingeffectofbutafosfaninsheep.InstitutfürPharmakologieundToxikologie,Veterin?rmedizinischeUniversit?t,Budapest,Hungary.BayerID12765.H?nselA.,FuhrmannH.,SallmannH.-P,KleeW.(1992):InfusionvonPropionateandButyratalsBelastungstestzurüberprüfungm?glicherButafosfanwirkungenaufdenEnergiestoffwechseldesRindes.Berl.Münch.Tier?rztl.Wschr.105,361-366.HasiSu-rong,DUXiao-yan,ZHUBei-lei,JIANGJin-shu(2004a):StudiesonEffectsofCompoundButaphosphanSolutiononEnduranceCapabilityandEnergyMetabolisminMice.ActaVeterinariaEtZootechnicaSinica,35(03),290-294.現(xiàn)在是14頁\一共有31頁\編輯于星期日降低冷熱刺激StressReduction/controlofcortisolincrease.HasiSu-rongetal.(2004a)*:p<0.05,**p<:0.001comparedtocontrolgroup***:p<0.05comparedtohighdosebutaphosphan******%Highdosebutaphosphan(n=15):250mg/kgbutaphosphanonceadayfor7daysorally.Lowdosebutaphosphan(n=15)125mg/kgbutaphosphanonceadayfor7daysorally.Controlgroup(n=15):10ml/kgphysiologicsalineonceadayfor7daysoral.Onehouraftertreatmentonthelastday,eachmousewasplacedIna300mlwide-mouthedflaskwhichwassealedwithadoublelayerofgauze.Inordertoevaluatethecoldtolerance,thiswasplacedinametaboliccageat5±0.5oCwithacyclicpump.But,fortheevaluationofheattolerancethetemperaturewas45±0.5oC.Inthecoldtolerancestudy,after10hoursthenumberofmicestillalivewasrecorded.Intheheattolerancestudy,after50minutes,thenumberofmicestillalivewasrecorded現(xiàn)在是15頁\一共有31頁\編輯于星期日.布他磷作用于組織缺氧HasiSu-rongetal.(2004a)*p<:0.05,**p<:0.001comparedtocontrolgroup***存活時間(分鐘)Highdosebutaphosphan(n=12):250mg/kgbutaphosphanonceadayfor7daysorally.Lowdosebutaphosphan(n=12)125mg/kgbutaphosphanonceadayfor7daysorally.Controlgroup(n=12):10ml/kgphysiologicsalineonceadayfor7daysoral.Onehouraftertreatmentonthelastday,eachmousewasplacedIna300mlwide-mouthedflaskwhichwassealedwithtransparentgladwrapThatdidnotadmitairandtimingwascommenced.Withtheterminationofbreathingastheendpoint,thetimeforeachmousetoexpirefromlackofoxygenwasnoted,soastodeterminetheeffectofbutaphosphanonthetoleranceofmicehypoxia.現(xiàn)在是16頁\一共有31頁\編輯于星期日刺激能量產(chǎn)生參考資料:HasiSu-rong,DUXiao-yan,ZHUBei-lei,JIANGJin-shu(2004a):StudiesonEffectsofCompoundButaphosphanSolutiononEnduranceCapabilityandEnergyMetabolisminMice.ActaVeterinariaEtZootechnicaSinica,35(03),290-294.HASISu-rong,JIANGJin-shu,DUXiao-yan,ZHUBei-lei(2005a):Anti-coldstresseffectsandmechanismsofcompoundbutaphosphansolution.ProgressinVeterinaryMedicine,26,(03),59-62.HASISu-rong,JIANGJin-shu,ZHUBei-lei,DUXiao-yan(2005b):StudiesonAnti-HeatStressEffectsandMechanismsofCompoundButafosfanSolution.ActaVeterinariaEtZootechnicaSinica,36(12),1334-1338.現(xiàn)在是17頁\一共有31頁\編輯于星期日布他磷刺激肝糖元產(chǎn)生Contentoflivergycogen(mg/g)*****=p<0.05,***=p<0.001ComparedtocontrolgroupHasiSu-rongetal.(2004a)Experiment1(n=12):250mg/kgbutaphosphanonceadayfor7daysorally.Experiment2(n=12):125mg/kgbutaphosphanonceadayfor7daysorally.Controlgroup(n=12):10ml/kgphysiologicsalinesolution.Onehourafterlasttreatmentonthelastday,miceweresacrificedandliverglycogencontentwasdeterminedviaspectrometer現(xiàn)在是18頁\一共有31頁\編輯于星期日布他磷刺激肌糖元產(chǎn)生Contentofmuscleglycogen(mg/g)*******=p<0.01,***=p<0.001ComparedtocontrolgroupHasiSu-rongetal.(2004a)Experiment1(n=12):250mg/kgbutaphosphanonceadayfor7daysorally.Experiment2(n=12):125mg/kgbutaphosphanonceadayfor7daysorally.Controlgroup(n=12):10ml/kgphysiologicsalinesolution.Onehourafterlasttreatmentonthelastday,miceweresacrificedandmuscleglycogencontentwasdeterminedviaspectrometer現(xiàn)在是19頁\一共有31頁\編輯于星期日提高肌肉中的Tri-phosphate(ATP)含量ContentofmuscleATP(mg/g)******=p<0.001ComparedtocontrolgroupHasiSu-rongetal.(2004a)Butaphosphantreatmentgroup(n=12):250mg/kgbutaphosphanonceadayfor7daysorally.Controlgroup(n=12):10ml/kgphysiologicsalinesolution.Onehourafterlasttreatmentonthelastday,miceweresacrificedandmuscleATPcontentwasdeterminedviaHPLC.現(xiàn)在是20頁\一共有31頁\編輯于星期日提高肝臟功能StudiesFürllM.,WitteckTh.,GengenbachS.,SchmidtB.(2006):Effectsofpre-operativeapplicationofbutaphosphanandcyanocobalamineonreconvalescenceclinico-chemicalparameters,antioxidavivemetabolismandpostoperativeabomosalemptyingincowswithabomosaldislocation.Tier?rztl.Prax.34(G):351-356.HASISu-rong,JIANGJin-shu,DUXiao-yan,ZHUBei-lei(2005a):Anti-coldstresseffectsandmechanismsofcompoundbutaphosphansolution.ProgressinVeterinaryMedicine,26,(03),59-62.HASISu-rong,JIANGJin-shu,ZHUBei-lei,DUXiao-yan(2005b):StudiesonAnti-heatStressEffectsandMechanismsofCompoundButafosfanSolution.ActaVeterinariaEtZootechnicaSinica,36(12),1334-1338.SommerH.,MarxD.,undStarkerG.(1971):StudiestoreducereproductivedisordersincattlebyusingCatosal?asmetaphylaxis.Dtsch.Tier?rtzl.Wschr.78,593–616..FlasshoffF.-H.(1974):Clinicalandchemicalbloodseruminvestigationsincattleandtreatmentstudieswithornithine-aspartate-productHMV20andwithCatosalforthereductionoffertilityandhealthdisorders.DoctorateThesis,Tier?rztlicheHochschuleHannover,Germany.MarbachW(1980):AlkalischePhosphatase(AP)undAspartataminotransferase(AST)desBlutplasmasalsParameterderKonditionvonRennpferdenunddieWirkungvonCoforta/CatosalaufdieseEnzyme.Vet.Med.Nahchr.,12.現(xiàn)在是21頁\一共有31頁\編輯于星期日CATOSAL:營養(yǎng)肝臟ASAT(U/l)50100150200250300350Catosal對照組谷草轉(zhuǎn)氨酶(ASAT)是一種線粒體內(nèi)的酶，當肝臟或肌肉損傷或肝臟代謝負擔過重是會釋放到血液中。科特壯能促進糖異生的過程，這樣減輕肝臟的負擔。0d1d2d3dpostOP科特壯-藥理作用現(xiàn)在是22頁\一共有31頁\編輯于星期日

游離脂肪酸(μmol/l)20060010001400180022000d1d2d3dCATOSAL:營養(yǎng)肝臟血液中的游離脂肪酸含量是脂肪代謝的指標，脂肪代謝不好時其含量高用科特壯治療后游離脂肪酸含量比未治療明顯降低Catosal對照組Catosal–

藥理作用現(xiàn)在是23頁\一共有31頁\編輯于星期日科特壯的成分VB12水溶性,提供鈷元素需要不斷攝入作用方式調(diào)節(jié)蛋白質(zhì)、脂類和碳水化合物的新陳代謝提供鈷元素，幫助紅細胞合成。促進蛋氨酸合成，而蛋氨酸是機體蛋白質(zhì)重要的合成原料。促進身體生長,提高食物利用率。黑色晶體,吸水性現(xiàn)在是24頁\一共有31頁\編輯于星期日科特壯-藥理作用CATOSAL:抗氧化作用布他磷是一種α-氨基磷酸,可以保護犬貓機體免受氧化損傷。CATOSAL:促進生長發(fā)育布他磷能夠影響寵物的中間代謝（GIESECKE1985），主要表現(xiàn)為促進能量代謝、提高蛋白質(zhì)合成（KAEMMERER1984,KIETZMANN1986）和促進生長發(fā)育。實驗證明，給予科特壯、維生素以及硒元素可使動物生長速度提高38%（El-Sherifetal.,1981）。促進生長