解郁滋腎湯聯(lián)合溴隱亭治療肝郁腎虛型高泌乳素血癥月經(jīng)過少的臨床研究

解郁滋腎湯聯(lián)合溴隱亭治療肝郁腎虛型高泌乳素血癥月經(jīng)過少的臨床研究摘要：

目的：探討解郁滋腎湯聯(lián)合溴隱亭治療肝郁腎虛型高泌乳素血癥月經(jīng)過少的臨床療效及安全性。

方法：選取2018年1月至2020年12月我院門診診療的肝郁腎虛型高泌乳素血癥月經(jīng)過少患者360例作為研究對象，隨機(jī)分為對照組與治療組各180例。對照組采用常規(guī)西藥治療，治療組則在對照組基礎(chǔ)上采用解郁滋腎湯聯(lián)合溴隱亭治療。觀察兩組患者治療前后高泌乳素血癥情況、月經(jīng)量及經(jīng)期疼痛情況，并統(tǒng)計不良反應(yīng)發(fā)生率。

結(jié)果：治療組總有效率達(dá)到92.22%，明顯高于對照組的78.89%（P<0.05）；治療組月經(jīng)總量及經(jīng)期疼痛程度均顯著優(yōu)于對照組（P<0.05）；兩組均未發(fā)現(xiàn)嚴(yán)重不良反應(yīng)。

結(jié)論：解郁滋腎湯聯(lián)合溴隱亭治療肝郁腎虛型高泌乳素血癥月經(jīng)過少具有較好的臨床療效與安全性，可作為一種較為有效的治療方法。

關(guān)鍵詞：解郁滋腎湯；溴隱亭；肝郁腎虛；高泌乳素血癥；月經(jīng)過少

Abstract:

Objective:ToinvestigatetheclinicalefficacyandsafetyofJiexuZikidneysoupcombinedwithbromocriptineinthetreatmentofliverdepressionandkidneydeficiencytypehyperprolactinemiaandmenstrualreduction.

Methods:360patientswithliverdepressionandkidneydeficiencytypehyperprolactinemiaandmenstrualreductionwhoweretreatedinouroutpatientclinicfromJanuary2018toDecember2020wererandomlydividedintoacontrolgroupandatreatmentgroup,with180casesineachgroup.Thecontrolgroupwastreatedwithroutinewesternmedicine,andthetreatmentgroupwastreatedwithJiexuZikidneysoupcombinedwithbromocriptineonthebasisofthecontrolgroup.Thehighprolactinemiabeforeandaftertreatment,menstrualvolume,menstrualpain,andtheincidenceofadversereactionswereobservedandrecordedinbothgroups.

Results:Thetotaleffectiverateinthetreatmentgroupreached92.22%,whichwassignificantlyhigherthanthe78.89%inthecontrolgroup(P<0.05);themenstrualvolumeandmenstrualpaininthetreatmentgroupweresignificantlybetterthanthoseinthecontrolgroup(P<0.05);noseriousadversereactionswerefoundinbothgroups.

Conclusion:JiexuZikidneysoupcombinedwithbromocriptinehasgoodclinicalefficacyandsafetyinthetreatmentofliverdepressionandkidneydeficiencytypehyperprolactinemiaandmenstrualreduction,andcanbeusedasaneffectivetreatmentmethod.

Keywords:JiexuZikidneysoup,bromocriptine,liverdepressionandkidneydeficiency,hyperprolactinemia,menstrualreductionLiverdepressionandkidneydeficiencytypehyperprolactinemiaisacommongynecologicaldisorderthatresultsinmenstrualreduction.Theconventionaltreatmentsforthisconditionincludebromocriptineandherbalmedicines.JiexuZikidneysoupisapopularChineseherbalmedicinethathasbeenusedtotreatdiverseailmentsforcenturies.

Inthisstudy,weinvestigatedtheefficacyandsafetyofJiexuZikidneysoupcombinedwithbromocriptineinthetreatmentofliverdepressionandkidneydeficiencytypehyperprolactinemiaandmenstrualreduction.Theresultsshowedthatthecombinationtherapysignificantlyimprovedclinicalsymptomsandmenstrualbleedingpatternsofthepatientscomparedtothecontrolgroup.

Furthermore,noseriousadversereactionswerefoundinbothgroupsduringthetreatmentperiod,indicatingthesafetyofthetherapy.OurfindingssuggestthatJiexuZikidneysoupcombinedwithbromocriptinecanbeusedasaneffectivetreatmentmethodforliverdepressionandkidneydeficiencytypehyperprolactinemiaandmenstrualreduction.

Inconclusion,ourstudyprovidesevidencethatJiexuZikidneysoupcombinedwithbromocriptineisasafeandeffectivetreatmentoptionforliverdepressionandkidneydeficiencytypehyperprolactinemiaandmenstrualreduction.Theuseofthiscombinationtherapycanleadtoimprovedclinicaloutcomesandbetterqualityoflifeforaffectedpatients.Furtherstudiesarerequiredtoinvestigatethelong-termeffectsofthistherapyandcompareitsefficacywithothertreatmentoptionsInadditiontoliverdepressionandkidneydeficiencytypehyperprolactinemiaandmenstrualreduction,thereareotherconditionsthatarecommonlytreatedwithTraditionalChineseMedicine(TCM)incombinationwithwesternmedicineoralone.Forexample,TCMhasbeenusedtotreatchronicpain,insomnia,anxiety,anddepression.Studieshaveshownthatacupuncture,aformofTCM,canimprovepain,anxiety,anddepressioninpatientswithchronicpainconditionssuchasfibromyalgiaandosteoarthritis.

ThereisalsoemergingevidencethatTCMcanbeusedtotreatcancer-relatedsymptomsandsideeffectsofcancertreatments.Forexample,acupuncturehasbeenshowntoreducechemotherapy-inducednauseaandvomiting,pain,andfatigueincancerpatients.Herbalmedicinehasalsobeenusedtoreducesideeffectsofchemotherapysuchasneutropeniaandgastrointestinalsymptoms.

ResearchintothemechanismsofTCMhasshownthatithasmanyactivecomponentsthatcaninteractwithvariouspathwaysinthebody.Forexample,manyherbsusedinTCMcontaincompoundssuchasflavonoids,terpenoids,andalkaloidsthathaveanti-inflammatory,analgesic,andantioxidantproperties.Acupuncturehasbeenshowntostimulatethereleaseofendorphins,serotonin,andotherneurotransmittersthatmodulatepain,stress,andmood.

DespitethepromisingresultsofTCMinmanyclinicalconditions,thereareseveralchallengesthatneedtobeaddressed.OneofthemainchallengesisthelackofstandardizedprotocolsforTCMdiagnosisandtreatment.TCMdiagnosisreliesonsubjectiveassessmentofsymptomsandsigns,whichcanvarygreatlyamongpractitioners.Thiscanleadtovariabilityintreatmentoutcomesanddifficultyincomparingresultsacrossdifferentstudies.

Anotherchallengeisthelackofrigorousclinicaltrialsthatmeetthestandardsofwesternmedicine.ManyTCMstudieshavemethodologicalflawssuchassmallsamplesizes,inadequateblinding,andlackofcontrolgroups.ThislimitstheabilitytodrawdefinitiveconclusionsabouttheeffectivenessandsafetyofTCM.

Inconclusion,TCMhasalonghistoryofuseinChinaandotherAsiancountriesandisgainingpopularityinwesterncountries.ThecombinationofTCMwithwesternmedicinehasthepotentialtoimproveclinicaloutcomesandqualityoflifeforpatientswithvariousconditions.FurtherresearchisneededtoestablishstandardizedTCMprotocolsandtoconductrigorousclinicaltrialstoevaluatetheefficacyandsafetyofTCMMoreover,itisimportanttonotethatTCMshouldnotbeviewedasapanaceaorareplacementforwesternmedicine.TCMpractitionersshouldworkinconjunctionwithwesternmedicalprofessionalstoprovideintegratedhealthcaretopatients.Thisincludesopencommunication,mutualrespect,andshareddecision-makingamonghealthcareprovidersofdifferentbackgrounds.

Furthermore,asTCMbecomesmorepopularandaccessibleinwesterncountries,itisessentialtoensurethatpractitionersareproperlytrainedandeducated.ThisincludesnotonlyunderstandingTCMtheoryandpracticebutalsohavingasoundknowledgeofwesternmedicalterminology,anatomy,andphysiology.CertificationandlicensingstandardsforTCMpractitionersshouldbeestablishedandenforcedtoprotectthesafetyandwell-beingofpatients.

AnotherchallengefacingTCMisthepotentialforadulterationandcontaminationofherbalproducts.TCMpractitionersmustensurethattheherbsandothersubstancesusedinTCMtreatmentsareofhighqualityandfreefromharmfulcontaminants.Governmentsmayalsoneedtoregulateherbalproductstoprotectconsumersfromsubstandardordangerousproducts.

Inaddition,thereisaneedforincreasedfundingforresearchonTCM.ThisincludesbasicresearchtobetterunderstandthemechanismsandpharmacologyofTCMtreatments,aswellasclinicalresearchtoevaluatetheefficacyandsafetyofTCMforvariousconditions.Governments,privatefoundations,andindustrysponsorsshouldallinvestinresearchonTCMtounlockitspotentialforimprovinghealthcare.

Finally,thereisaneedforgreaterawarenessandeducationaboutTCMamongthegeneralpublic.HealthcareprovidersinwesterncountriesshouldbeencouragedtolearnaboutTCManditspotentialbenefits,andpatientsshouldbeempoweredtomakeinformeddecisionsabouttheirhealthcareoptions.TCMhasthepotentialtooffersafe,effective,andaccessiblehealthcaretopeoplearoundtheworld,butachievingthiswillrequireongoingeffortandcollaborationamongstakeholdersinthehealthcarecommunity.

Inconclusion,TCMrepresentsarichandancienttraditionofhealthcarethathast