《免疫學(xué)基礎(chǔ)知識》

基礎(chǔ)知識培訓(xùn)手冊2008版僅供內(nèi)部培訓(xùn)使用目錄1.感染與疾病1.1介紹……………………51.2病毒……………………101.3細菌……………………191.4流行病學(xué)………………311.5抗擊傳染性疾病………392.免疫2.1介紹……………………482.2先天性免疫……………512.3后天性免疫……………552.4抗體介導(dǎo)免疫…………642.5細胞介導(dǎo)免疫…………772.6免疫病理學(xué)……………843.疫苗學(xué)3.1被動和主動免疫………933.2疫苗種類………………1013.3疫苗檢測………………1163.4疫苗的使用……………129感染與疾病1.感染與疾病什么引起感染?感染如何引起疾病?什么時候感染引起疾病?1.1Introduction1.2Viruses1.3Bacteria1.4Epidemiology1.5Combating

infectiousdisease

Quizone介紹1.1Introduction

Theproblem

Somestatistics

Achangingscene1.2Viruses1.3Bacteria1.4Epidemiology1.5Combating

infectiousdisease

Quizone乙肝病毒白日咳桿菌麻疹病毒破傷風桿菌白喉桿菌在20世紀末引起死亡的病因01020304050全部百分比其它新生兒與圍產(chǎn)期感染性疾病循環(huán)系統(tǒng)疾病腫瘤呼吸系統(tǒng)疾病全球工業(yè)化國家發(fā)展中國家感染性疾病的問題1.1Introduction

Theproblem

Somestatistics

Achangingscene1.2Viruses1.3Bacteria1.4Epidemiology1.5Combating

infectiousdisease

Quizone一些統(tǒng)計數(shù)字1.1Introduction

Theproblem

Somestatistics

Achangingscene1.2Viruses1.3Bacteria1.4Epidemiology1.5Combating

infectiousdisease

Quizone1975-1999年報告的脊灰病例200004000060000197519801985199019952000一些統(tǒng)計數(shù)字1975-1999年全球疫苗接種覆蓋率100%80%60%40%20%198019851990199520001.1Introduction

Theproblem

Somestatistics

Achangingscene1.2Viruses1.3Bacteria1.4Epidemiology1.5Combating

infectiousdisease

QuizoneMeaslesDTPBCG正在變化的情況挑戰(zhàn):新的感染性疾病老的傳染病死灰復(fù)燃耐藥傳染病向新領(lǐng)域的播散在控制不利地區(qū)傳染病的播散1.1Introduction

Theproblem

Somestatistics

Achangingscene1.2Viruses1.3Bacteria1.4Epidemiology1.5Combating

infectiousdisease

Quizone病毒本章涉及的題目是:病毒的結(jié)構(gòu)與分類病毒如何復(fù)制病毒如何引起疾病一些重要病毒和它們引起的疾病1.1Introduction1.2Viruses

Generaldescription

Classification

Replication

Virusesanddisease

Viraldiseases

Someimportant

viruses1.3Bacteria1.4Epidemiology1.5Combating

infectiousdiseases

Quizone一般描述病毒外膜(蛋白,糖蛋白或脂蛋白)衣殼(蛋白)病毒核心(DNA或RNA)1.1Introduction1.2Viruses

Generaldescription

Classification

Replication

Virusesanddisease

Viraldiseases

Someimportant

viruses1.3Bacteria1.4Epidemiology1.5Combating

infectiousdiseases

Quizone分類DNARNA單鏈雙鏈病毒外膜甲肝病毒脊灰病毒流感病毒麻疹病毒腮腺炎病毒風疹病毒皰疹病毒乙肝病毒1.1Introduction1.2Viruses

Generaldescription

Classification

Replication

Virusesanddisease

Viraldiseases

Someimportant

viruses1.3Bacteria1.4Epidemiology1.5Combating

infectiousdiseases

Quizone復(fù)制1.1Introduction1.2Viruses

Generaldescription

Classification

Replication

Virusesanddisease

Viraldiseases

Someimportant

viruses1.3Bacteria1.4Epidemiology1.5Combating

infectiousdiseases

Quizone復(fù)制1.1Introduction1.2Viruses

Generaldescription

Classification

Replication

Virusesanddisease

Viraldiseases

Someimportant

viruses1.3Bacteria1.4Epidemiology1.5Combating

infectiousdiseases

Quizone病毒與疾病病毒能夠:損害和摧毀細胞例如流感干擾細胞生長例如先天性風疹,腫瘤激活免疫反應(yīng)來摧毀被感染細胞例如甲型肝炎1.1Introduction1.2Viruses

Generaldescription

Classification

Replication

Virusesanddisease

Viraldiseases

Someimportant

viruses1.3Bacteria1.4Epidemiology1.5Combating

infectiousdiseases

Quizone病毒感染的特征局部例如

流感,輪狀病毒病毒在入口處復(fù)制在感染的1-3天出現(xiàn)局部癥狀和體征全身例如

麻疹病毒通過全身播散感染器官和組織在1-3周出現(xiàn)全身癥狀和體征1.1Introduction1.2Viruses

Generaldescription

Classification

Replication

Virusesanddisease

Viraldiseases

Someimportant

viruses1.3Bacteria1.4Epidemiology1.5Combating

infectiousdiseases

Quizone一些重要的病毒甲肝乙肝賀福立適

(雙福立適,Hepatyrix)安在時

(雙福立適,Tritanrix&Infanrixcombos)病毒疾病GSK疫苗麻疹腮腺炎風疹普祥立適

(Rimevax,Eolarix)普祥立適普祥立適(Ervevax,Eolarix)1.1Introduction1.2Viruses

Generaldescription

Classification

Replication

Virusesanddisease

Viraldiseases

Someimportant

viruses1.3Bacteria1.4Epidemiology1.5Combating

infectiousdiseases

Quizone一些重要的病毒病毒疾病GSKVACCINE(S)水痘流感脊灰威可檬福祿立適,Influsplit,AlpharixPolioSabin(Infanrixcombos)1.1Introduction1.2Viruses

Generaldescription

Classification

Replication

Virusesanddisease

Viraldiseases

Someimportant

viruses1.3Bacteria1.4Epidemiology1.5Combating

infectiousdiseases

Quizone細菌本章涉及的題目是:細菌的結(jié)構(gòu)和分類細菌如何繁殖細菌如何引起疾病一些重要細菌和它們引起的疾病1.1Introduction1.2Viruses1.3Bacteria

Generaldescription

Structure

Multiplication

Bacteriaanddisease

Bacterialdiseases

Someimportant

bacteria1.4Epidemiology1.5Combating

infectiousdisease

Quizone一般描述細胞壁基因物質(zhì)(DNA)核糖體胞漿細胞膜1.1Introduction1.2Viruses1.3Bacteria

Generaldescription

Structure

Multiplication

Bacteriaanddisease

Bacterialdiseases

Someimportant

bacteria1.4Epidemiology1.5Combating

infectiousdisease

Quizone結(jié)構(gòu)與分類鞭毛纖毛莢膜1.1Introduction1.2Viruses1.3Bacteria

Generaldescription

Structure

Multiplication

Bacteriaanddisease

Bacterialdiseases

Someimportant

bacteria1.4Epidemiology1.5Combating

infectiousdisease

Quizone革蘭氏陰性外膜結(jié)構(gòu)與分類細胞壁革蘭氏陽性肽聚糖細胞漿膜1.1Introduction1.2Viruses1.3Bacteria

Generaldescription

Structure

Multiplication

Bacteriaanddisease

Bacterialdiseases

Someimportant

bacteria1.4Epidemiology1.5Combating

infectiousdisease

Quizone結(jié)構(gòu)與分類細菌細胞形態(tài)形態(tài)名稱例如螺旋體螺旋體百日咳球桿菌鏈球菌肺炎鏈球菌腦膜炎球菌球菌白喉破傷風流感嗜血桿菌桿菌1.1Introduction1.2Viruses1.3Bacteria

Generaldescription

Structure

Multiplication

Bacteriaanddisease

Bacterialdiseases

Someimportant

bacteria1.4Epidemiology1.5Combating

infectiousdisease

Quizone繁殖二分裂法1.1Introduction1.2Viruses1.3Bacteria

Generaldescription

Structure

Multiplication

Bacteriaanddisease

Bacterialdiseases

Someimportant

bacteria1.4Epidemiology1.5Combating

infectiousdisease

Quizone芽孢形成出芽1.1Introduction1.2Viruses1.3Bacteria

Generaldescription

Structure

Multiplication

Bacteriaanddisease

Bacterialdiseases

Someimportant

bacteria1.4Epidemiology1.5Combating

infectiousdisease

Quizone細菌與疾病細菌引起的疾病:通過入侵有能力在體內(nèi)繁殖和快速播散通過產(chǎn)生外毒素在生長中分泌蛋白，通常有特定作用通過產(chǎn)生內(nèi)毒素當細菌細胞死亡時釋放屬于非專一作用1.1Introduction1.2Viruses1.3Bacteria

Generaldescription

Structure

Multiplication

Bacteriaanddisease

Bacterialdiseases

Someimportant

bacteria1.4Epidemiology1.5Combating

infectiousdisease

Quizone細菌性疾病細菌性疾病可以有:特殊的臨床癥狀典型的臨床體征非特殊的臨床癥狀臨床特征依賴于感染部位，而不是感染細菌不同細菌可以產(chǎn)生同樣癥狀1.1Introduction1.2Viruses1.3Bacteria

Generaldescription

Structure

Multiplication

Bacteriaanddisease

Bacterialdiseases

Someimportant

bacteria1.4Epidemiology1.5Combating

infectiousdisease

Quizone細菌性疾病特定感染的潛伏期出現(xiàn)癥狀前的天數(shù)0510152025感染霍亂白喉白日咳傷寒熱萊姆病1.1Introduction1.2Viruses1.3Bacteria

Generaldescription

Structure

Multiplication

Bacteriaanddisease

Bacterialdiseases

Someimportant

bacteria1.4Epidemiology1.5Combating

infectiousdisease

Quizone一些重要的細菌細菌疾病GSK疫苗白喉破傷風百日咳英芬立適,Infanrixcombos,Tritanrix,Tritanrixcombos,BoostrixDitanrixandTanrix1.1Introduction1.2Viruses1.3Bacteria

Generaldescription

Structure

Multiplication

Bacteriaanddisease

Bacterialdiseases

Someimportant

bacteria1.4Epidemiology1.5Combating

infectiousdisease

Quizone一些重要的細菌細菌疾病GSK疫苗Hib疾病傷寒熱腦膜炎賀新立適

(andcombos)Typherix(Hepatyrix)Mencevaxrange1.1Introduction1.2Viruses1.3Bacteria

Generaldescription

Structure

Multiplication

Bacteriaanddisease

Bacterialdiseases

Someimportant

bacteria1.4Epidemiology1.5Combating

infectiousdisease

Quizone流行病學(xué)本章涉及的題目是:感染來源感染傳播一些共同問題1.1Introduction1.2Viruses1.3Bacteria1.4Epidemiology

Sourcesofinfection

Routesofinfection

Somecommonterms1.5Combating

infectiousdisease

Quizone感染來源外源性感染來源于身體之外內(nèi)源性感染來源于身體內(nèi)或身體上1.1Introduction1.2Viruses1.3Bacteria1.4Epidemiology

Sourcesofinfection

Routesofinfection

Somecommonterms1.5Combating

infectiousdisease

Quizone感染來源外源性感染來源1.1Introduction1.2Viruses1.3Bacteria1.4Epidemiology

Sourcesofinfection

Routesofinfection

Somecommonterms1.5Combating

infectiousdisease

Quizone感染來源內(nèi)源性感染1.1Introduction1.2Viruses1.3Bacteria1.4Epidemiology

Sourcesofinfection

Routesofinfection

Somecommonterms1.5Combating

infectiousdisease

Quizone感染途徑1.1Introduction1.2Viruses1.3Bacteria1.4Epidemiology

Sourcesofinfection

Routesofinfection

Somecommonterms1.5Combating

infectiousdisease

Quizone流行病學(xué)定義衡量疾病負擔發(fā)病率在特點時期某種疾病的新發(fā)病數(shù)流行率在特定時間點感染的全部數(shù)量患病率在特定時期某種疾病和它的并發(fā)癥的數(shù)量1.1Introduction1.2Viruses1.3Bacteria1.4Epidemiology

Sourcesofinfection

Routesofinfection

Somecommonterms1.5Combating

infectiousdisease

Quizone流行病學(xué)定義死亡率的衡量病死率在特定時間由某種疾病致死的數(shù)量病例死亡率由某種疾病致死的百分比1.1Introduction1.2Viruses1.3Bacteria1.4Epidemiology

Sourcesofinfection

Routesofinfection

Somecommonterms1.5Combating

infectiousdisease

Quizone流行病學(xué)定義地方性流行流行病

例

數(shù)

量1.1Introduction1.2Viruses1.3Bacteria1.4Epidemiology

Sourcesofinfection

Routesofinfection

Somecommonterms1.5Combating

infectiousdisease

Quizone抗擊傳染性疾病本章涉及的題目是:一般措施抗微生物藥物1.1Introduction1.2Viruses1.3Bacteria1.4Epidemiology1.5Combating

infectiousdiseases

Generalmeasures

Anti-microbialdrugs

Resistance

Preventionorcure?

Vaccination

Quizone藥物治療的問題通過接種預(yù)防干擾一般措施感染來源宿主Route預(yù)防隔離與清除保護1.1Introduction1.2Viruses1.3Bacteria1.4Epidemiology1.5Combating

infectiousdiseases

Generalmeasures

Anti-microbialdrugs

Resistance

Preventionorcure?

Vaccination

Quizone能治療:治療很多感染性疾病抗生素但可以:使用不當和無效有副作用改變?nèi)梭w正常菌群1.1Introduction1.2Viruses1.3Bacteria1.4Epidemiology1.5Combating

infectiousdiseases

Generalmeasures

Anti-microbialdrugs

Resistance

Preventionorcure?

Vaccination

Quizone耐藥問題耐藥性肺炎球菌的傳播首次在西班牙被確認Source:KlugmanK.SouthAfricanInstituteofMedicalResearch,fromWHOAnnualReport19981.1Introduction1.2Viruses1.3Bacteria1.4Epidemiology1.5Combating

infectiousdiseases

Generalmeasures

Anti-microbialdrugs

Resistance

Preventionorcure?

Vaccination

Quizone耐藥問題在英國醫(yī)院耐甲氧西林金葡菌Source:ReacherWHetal.BrMedJ2000;320,213WHOAnnualReport1998010%20%30%8990919293949596971.1Introduction1.2Viruses1.3Bacteria1.4Epidemiology1.5Combating

infectiousdiseases

Generalmeasures

Anti-microbialdrugs

Resistance

Preventionorcure?

Vaccination

Quizone預(yù)防勝于治療更容易更人性化預(yù)防或治療更節(jié)省費用控制疾病更有效1.1Introduction1.2Viruses1.3Bacteria1.4Epidemiology1.5Combating

infectiousdiseases

Generalmeasures

Anti-microbialdrugs

Resistance

Preventionorcure?

Vaccination

Quizone免疫接種大規(guī)模接種DTPa在瑞典接種英芬立適對百日咳的由影響2000HallanderHOetal.SwedishInstInfControl,Report

14May199919901995Casesofpertussis1985500100015001.1Introduction1.2Viruses1.3Bacteria1.4Epidemiology1.5Combating

infectiousdiseases

Generalmeasures

Anti-microbialdrugs

Resistance

Preventionorcure?

Vaccination

Quizone基礎(chǔ)免疫課程免疫2.1Introduction2.2Innateimmunity2.3Adaptiveimmunity2.4Antibody-mediated

immunity2.5Cell-mediated

immunity2.6Immunopathology

Quiztwo2.免疫什么保護我們免除疾病?這個防御機制如何工作?介紹2.1Introduction

Invasionand

immunity

Innateandadaptive

immunity2.2Innateimmunity2.3Adaptiveimmunity2.4Antibody-mediated

immunity2.5Cell-mediated

immunity2.6Immunopathology

Quiztwo周圍淋巴組織吞噬細胞淋巴細胞中央淋巴組織抗體入侵與免疫防御性免疫限制入侵確認摧毀病原菌入侵2.1Introduction

Invasionand

immunity

Innateandadaptive

immunity2.2Innateimmunity2.3Adaptiveimmunity2.4Antibody-mediated

immunity2.5Cell-mediated

immunity2.6Immunopathology

Quiztwo先天性和后天性免疫先天性免疫防御第一線在出生時存在非特異性后天性免疫防御第二道防線學(xué)習(xí)特異2.1Introduction

Invasionand

immunity

Innateandadaptive

immunity2.2Innateimmunity2.3Adaptiveimmunity2.4Antibody-mediated

immunity2.5Cell-mediated

immunity2.6Immunopathology

Quiztwo先天性免疫本章節(jié)涉及題目有:物理，化學(xué)和生物屏障天然抗感染物質(zhì)吞噬2.1Introduction2.2Innateimmunity

Physical,chemical

&biologicalbarriers

Naturalanti-infective

agents

Phagocytosis2.3Adaptiveimmunity2.4Antibody-mediated

immunity2.5Cell-mediated

immunity2.6Immunopathology

Quiztwo物理，化學(xué)和生物屏障物理屏障化學(xué)屏障細菌菌群皮膚物理屏障化學(xué)屏障粘膜粘膜酸堿細菌菌群消化道粘膜纖毛上皮呼吸道2.1Introduction2.2Innateimmunity

Physical,chemical

&biologicalbarriers

Naturalanti-infective

agents

Phagocytosis2.3Adaptiveimmunity2.4Antibody-mediated

immunity2.5Cell-mediated

immunity2.6Immunopathology

Quiztwo天然抗感染物質(zhì)抗細菌物質(zhì)

溶菌酶在眼淚和其它分泌物中破碎細胞壁抗病毒物質(zhì)

干擾素合成抗病毒感染限制病毒復(fù)制補體破碎細胞壁促進病原菌銷毀2.1Introduction2.2Innateimmunity

Physical,chemical

&biologicalbarriers

Naturalanti-infective

agents

Phagocytosis2.3Adaptiveimmunity2.4Antibody-mediated

immunity2.5Cell-mediated

immunity2.6Immunopathology

Quiztwo吞噬病原黏附，消化，殺滅，趨化性吞噬2.1Introduction2.2Innateimmunity

Physical,chemical

&biologicalbarriers

Naturalanti-infective

agents

Phagocytosis2.3Adaptiveimmunity2.4Antibody-mediated

immunity2.5Cell-mediated

immunity2.6Immunopathology

Quiztwo后天性免疫本章節(jié)涉及題目有:抗原免疫反應(yīng)機制淋巴細胞來源循環(huán)克隆擴增免疫反應(yīng)和免疫記憶2.1Introduction2.2Innateimmunity2.3Adaptiveimmunity

Antigens

Mechanismsof

immuneresponse

Lymphocytes

Thecirculationof

lymphocytes

Clonalexpansion

oflymphocytes

Immuneresponses

andmemory

Primaryand

secondaryresponses2.4Antibody-mediated

immunity2.5Cell-mediated

immunity2.6Immunopathology

Quiztwo抗原抗原是:激活免疫反應(yīng)的物質(zhì)‘非我’通常是很大的，復(fù)雜的分子通常由蛋白和多糖構(gòu)成2.1Introduction2.2Innateimmunity2.3Adaptiveimmunity

Antigens

Mechanismsof

immuneresponse

Lymphocytes

Thecirculationof

lymphocytes

Clonalexpansion

oflymphocytes

Immuneresponses

andmemory

Primaryand

secondaryresponses2.4Antibody-mediated

immunity2.5Cell-mediated

immunity2.6Immunopathology

Quiztwo抗原舉例乙肝病毒表面抗原(HBsAg)Pre-S1和pre-S2抗原‘e’抗原(HBeAg)核心抗原(HBcAg)百日咳百日咳毒素絲狀血凝素百日咳桿菌粘附素菌毛抗原2.1Introduction2.2Innateimmunity2.3Adaptiveimmunity

Antigens

Mechanismsof

immuneresponse

Lymphocytes

Thecirculationof

lymphocytes

Clonalexpansion

oflymphocytes

Immuneresponses

andmemory

Primaryand

secondaryresponses2.4Antibody-mediated

immunity2.5Cell-mediated

immunity2.6Immunopathology

Quiztwo免疫反應(yīng)機制細胞介導(dǎo)特定細胞擴增在細胞內(nèi)指導(dǎo)對付抗原

T-淋巴細胞介導(dǎo)B-淋巴細胞介導(dǎo)(T-淋巴也參與)抗體介導(dǎo)產(chǎn)生特定蛋白(抗體)指導(dǎo)對付循環(huán)抗原2.1Introduction2.2Innateimmunity2.3Adaptiveimmunity

Antigens

Mechanismsof

immuneresponse

Lymphocytes

Thecirculationof

lymphocytes

Clonalexpansion

oflymphocytes

Immuneresponses

andmemory

Primaryand

secondaryresponses2.4Antibody-mediated

immunity2.5Cell-mediated

immunity2.6Immunopathology

Quiztwo淋巴細胞在胸腺成熟T-淋巴細胞骨髓干細胞B-淋巴細胞在骨髓成熟2.1Introduction2.2Innateimmunity2.3Adaptiveimmunity

Antigens

Mechanismsof

immuneresponse

Lymphocytes

Thecirculationof

lymphocytes

Clonalexpansion

oflymphocytes

Immuneresponses

andmemory

Primaryand

secondaryresponses2.4Antibody-mediated

immunity2.5Cell-mediated

immunity2.6Immunopathology

Quiztwo淋巴細胞循環(huán)脾淋巴節(jié)骨髓胸腺血流2.1Introduction2.2Innateimmunity2.3Adaptiveimmunity

Antigens

Mechanismsof

immuneresponse

Lymphocytes

Thecirculationof

lymphocytes

Clonalexpansion

oflymphocytes

Immuneresponses

andmemory

Primaryand

secondaryresponses2.4Antibody-mediated

immunity2.5Cell-mediated

immunity2.6Immunopathology

Quiztwo淋巴細胞克隆擴增淋巴細胞克隆(全都一樣)不成熟淋巴池(每個都不同)抗原特定刺激淋巴細胞2.1Introduction2.2Innateimmunity2.3Adaptiveimmunity

Antigens

Mechanismsof

immuneresponse

Lymphocytes

Thecirculationof

lymphocytes

Clonalexpansion

oflymphocytes

Immuneresponses

andmemory

Primaryand

secondaryresponses2.4Antibody-mediated

immunity2.5Cell-mediated

immunity2.6Immunopathology

Quiztwo免疫反應(yīng)和免疫記憶CTLCTL細胞介導(dǎo)免疫輔助T-細胞細胞毒淋巴細胞記憶細胞T-細胞THTHTmTm激活的淋巴細胞抗體介導(dǎo)免疫抗體產(chǎn)生細胞記憶B-細胞BmBm2.1Introduction2.2Innateimmunity2.3Adaptiveimmunity

Antigens

Mechanismsof

immuneresponse

Lymphocytes

Thecirculationof

lymphocytes

Clonalexpansion

oflymphocytes

Immuneresponses

andmemory

Primaryand

secondaryresponses2.4Antibody-mediated

immunity2.5Cell-mediated

immunity2.6Immunopathology

Quiztwo原發(fā)和繼發(fā)免疫反應(yīng)免疫反應(yīng)強度Time1020304050初次接觸第二次接觸原發(fā)反應(yīng)繼發(fā)反應(yīng)2.1Introduction2.2Innateimmunity2.3Adaptiveimmunity

Antigens

Mechanismsof

immuneresponse

Lymphocytes

Thecirculationof

lymphocytes

Clonalexpansion

oflymphocytes

Immuneresponses

andmemory

Primaryand

secondaryresponses2.4Antibody-mediated

immunity2.5Cell-mediated

immunity2.6Immunopathology

Quiztwo抗體介導(dǎo)免疫本章節(jié)涉及題目有:抗體介導(dǎo)免疫的作用抗體介導(dǎo)免疫的機制抗體和它們的功能2.1Introduction2.2Innateimmunity2.3Adaptiveimmunity2.4Antibody-mediated

immunity

Theroleofantibody-

mediatedimmunity

Themechanismof

antibody-mediated

immunity

Functionofantibody

Structureofantibody

Classesofantibody

Theswitch

Defencesagainst

bacteria

Defencesagainst

viruses2.5Cell-mediated

immunity2.6Immunopathology

Quiztwo抗體介導(dǎo)免疫的作用抗體介導(dǎo)免疫:抵抗細胞外病原體抵抗細菌中非常重要…對細胞內(nèi)病原體無效在病毒進入細胞前非常重要2.1Introduction2.2Innateimmunity2.3Adaptiveimmunity2.4Antibody-mediated

immunity

Theroleofantibody-

mediatedimmunity

Themechanismof

antibody-mediated

immunity

Functionofantibody

Structureofantibody

Classesofantibody

Theswitch

Defencesagainst

bacteria

Defencesagainst

viruses2.5Cell-mediated

immunity2.6Immunopathology

Quiztwo抗體介導(dǎo)免疫的機制非T-細胞依賴的B-細胞抗原刺激B-淋巴細胞抗原被激活的B-淋巴細胞2.1Introduction2.2Innateimmunity2.3Adaptiveimmunity2.4Antibody-mediated

immunity

Theroleofantibody-

mediatedimmunity

Themechanismof

antibody-mediated

immunity

Functionofantibody

Structureofantibody

Classesofantibody

Theswitch

Defencesagainst

bacteria

Defencesagainst

viruses2.5Cell-mediated

immunity2.6Immunopathology

Quiztwo抗體介導(dǎo)免疫的機制T-細胞依賴的B-細胞抗原刺激含抗原的細胞TH-淋巴細胞被激活的B-淋巴細胞2.1Introduction2.2Innateimmunity2.3Adaptiveimmunity2.4Antibody-mediated

immunity

Theroleofantibody-

mediatedimmunity

Themechanismof

antibody-mediated

immunity

Functionofantibody

Structureofantibody

Classesofantibody

Theswitch

Defencesagainst

bacteria

Defencesagainst

viruses2.5Cell-mediated

immunity2.6Immunopathology

Quiztwo抗體介導(dǎo)免疫的機制B-細胞擴增和轉(zhuǎn)化擴增記憶B-細胞漿細胞抗體被激活的B-細胞2.1Introduction2.2Innateimmunity2.3Adaptiveimmunity2.4Antibody-mediated

immunity

Theroleofantibody-

mediatedimmunity

Themechanismof

antibody-mediated

immunity

Functionofantibody

Structureofantibody

Classesofantibody

Theswitch

Defencesagainst

bacteria

Defencesagainst

viruses2.5Cell-mediated

immunity2.6Immunopathology

Quiztwo抗體功能抗體抗原抗原-抗體復(fù)合物2.1Introduction2.2Innateimmunity2.3Adaptiveimmunity2.4Antibody-mediated

immunity

Theroleofantibody-

mediatedimmunity

Themechanismof

antibody-mediated

immunity

Functionofantibody

Structureofantibody

Classesofantibody

Theswitch

Defencesagainst

bacteria

Defencesagainst

viruses2.5Cell-mediated

immunity2.6Immunopathology

Quiztwo抗體功能激活補體C補體:

-直接攻擊細菌細胞

-促進吞噬

-加強炎癥和免疫反應(yīng)增強吞噬作用2.1Introduction2.2Innateimmunity2.3Adaptiveimmunity2.4Antibody-mediated

immunity

Theroleofantibody-

mediatedimmunity

Themechanismof

antibody-mediated

immunity

Functionofantibody

Structureofantibody

Classesofantibody

Theswitch

Defencesagainst

bacteria

Defencesagainst

viruses2.5Cell-mediated

immunity2.6Immunopathology

Quiztwo抗體結(jié)構(gòu)抗原結(jié)合位點功能區(qū)位置2.1Introduction2.2Innateimmunity2.3Adaptiveimmunity2.4Antibody-mediated

immunity

Theroleofantibody-

mediatedimmunity

Themechanismof

antibody-mediated

immunity

Functionofantibody

Structureofantibody

Classesofantibody

Theswitch

Defencesagainst

bacteria

Defencesagainst

viruses2.5Cell-mediated

immunity2.6Immunopathology

Quiztwo抗體分類IgMIgG2.1Introduction2.2Innateimmunity2.3Adaptiveimmunity2.4Antibody-mediated

immunity

Theroleofantibody-

mediatedimmunity

Themechanismof

antibody-mediated

immunity

Functionofantibody

Structureofantibody

Classesofantibody

Theswitch

Defencesagainst

bacteria

Defencesagainst

viruses2.5Cell-mediated

immunity2.6Immunopathology

Quiztwo抗體分類IgEIgDIgA分泌性IgA2.1Introduction2.2Innateimmunity2.3Adaptiveimmunity2.4Antibody-mediated

immunity

Theroleofantibody-

mediatedimmunity

Themechanismof

antibody-mediated

immunity

Functionofantibody

Structureofantibody

Classesofantibody

Theswitch

Defencesagainst

bacteria

Defencesagainst

viruses2.5Cell-mediated

immunity2.6Immunopathology

Quiztwo轉(zhuǎn)換抗體濃度天510152025IgMIgG抗原2.1Introduction2.2Innateimmunity2.3Adaptiveimmunity2.4Antibody-mediated

immunity

Theroleofantibody-

mediatedimmunity

Themechanismof

antibody-mediated

immunity

Functionofantibody

Structureofantibody

Classesofantibody

Theswitch

Defencesagainst

bacteria

Defencesagainst

viruses2.5Cell-mediated

immunity2.6Immunopathology

Quiztwo抵御細菌非特異性抵御入侵物理，化學(xué)和生物屏障吞噬限制繁殖特異性免疫提供進一步保護尤其是抗體介導(dǎo)免疫:

中和毒素

促進吞噬

激活補體2.1Introduction2.2Innateimmunity2.3Adaptiveimmunity2.4Antibody-mediated

immunity

Theroleofantibody-

mediatedimmunity

Themechanismof

antibody-mediated

immunity

Functionofantibody

Structureofantibody

Classesofantibody

Theswitch

Defencesagainst

bacteria

Defencesagainst

viruses2.5Cell-mediated

immunity2.6Immunopathology

Quiztwo抵御病毒非特異性限制進入干擾素限制復(fù)制特異性免疫提供進一步保護抗體介導(dǎo)免疫能限制病毒傳播細胞介導(dǎo)免疫能摧毀病毒感染的宿主細胞2.1Introduction2.2Innateimmunity2.3Adaptiveimmunity2.4Antibody-mediated

immunity

Theroleofantibody-

mediatedimmunity

Themechanismof

antibody-mediated

immunity

Functionofantibody

Structureofantibody

Classesofantibody

Theswitch

Defencesagainst

bacteria

Defencesagainst

viruses2.5Cell-mediated

immunity2.6Immunopathology

Quiztwo細胞介導(dǎo)免疫本章節(jié)涉及題目有:細胞介導(dǎo)免