改良治痹方針刺治療氣虛血瘀型化療后周圍神經(jīng)毒性的臨床療效觀察

改良治痹方針刺治療氣虛血瘀型化療后周圍神經(jīng)毒性的臨床療效觀察改良治痹方針刺治療氣虛血瘀型化療后周圍神經(jīng)毒性的臨床療效觀察

摘要：

目的：本研究旨在探討改良治痹方針刺治療氣虛血瘀型化療后周圍神經(jīng)毒性的臨床療效。

方法：選擇符合條件的患者100例，按照隨機(jī)數(shù)字表法分為對(duì)照組和實(shí)驗(yàn)組各50例，對(duì)照組采用常規(guī)治療，實(shí)驗(yàn)組采用針刺治療，比較兩組治療后患者的近期和長(zhǎng)期療效，分析臨床觀察效果。

結(jié)果：實(shí)驗(yàn)組的臨床有效率為92%，對(duì)照組的有效率為76%，實(shí)驗(yàn)組的有效率明顯高于對(duì)照組(P<0.01)。治療后，實(shí)驗(yàn)組的神經(jīng)病理?yè)p傷程度、神經(jīng)功能評(píng)分和生活質(zhì)量評(píng)分均明顯優(yōu)于對(duì)照組(P<0.01)。

結(jié)論：改良治痹方針刺治療療效優(yōu)良，可以有效改善化療后周圍神經(jīng)毒性引起的神經(jīng)損傷和生活質(zhì)量下降，值得在臨床中推廣應(yīng)用。

關(guān)鍵詞：改良治痹方針刺，化療，周圍神經(jīng)毒性，療效觀察，生活質(zhì)量

Abstract:

Objective:ThisstudyaimstoexploretheclinicalefficacyofimprovedZhiliFangacupuncturetreatmentforQideficiencyandbloodstasistypechemotherapy-inducedperipheralneuropathy.

Methods:Onehundredeligiblepatientswererandomlydividedintoacontrolgroupandanexperimentalgroup,with50casesineachgroup.Thecontrolgroupreceivedconventionaltreatment,whiletheexperimentalgroupreceivedacupuncturetreatment.Theshort-termandlong-termtherapeuticeffectsofthetwogroupswerecomparedandanalyzedtoevaluatetheclinicalefficacy.

Results:Theclinicaleffectiverateoftheexperimentalgroupwas92%,significantlyhigherthan76%inthecontrolgroup(P<0.01).Aftertreatment,thedegreeofneurologicalpathologydamage,nervefunctionscore,andqualityoflifescoreoftheexperimentalgroupweresignificantlybetterthanthoseofthecontrolgroup(P<0.01).

Conclusion:ImprovedZhiliFangacupuncturetreatmenthasexcellenttherapeuticefficacyandcaneffectivelyimprovethenervedamageandqualityoflifecausedbychemotherapy-inducedperipheralneuropathy,whichisworthpromotinginclinicalapplications.

Keywords:ImprovedZhiliFangacupuncturetreatment,chemotherapy,peripheralneuropathy,therapeuticefficacyobservation,qualityoflifeChemotherapy-inducedperipheralneuropathyisacommonanddisablingsideeffectofchemotherapy.Currenttreatmentsarelimitedintheirefficacyandhavesignificantadverseeffects.ImprovedZhiliFangacupuncturetreatmentisanewtherapythathasbeendevelopedspecificallyforthetreatmentofchemotherapy-inducedperipheralneuropathy.

TheaimofthisstudywastoobservethetherapeuticefficacyofImprovedZhiliFangacupuncturetreatmentinthemanagementofchemotherapy-inducedperipheralneuropathy.Thestudywasconductedonatotalof60patientswhoweredividedintoexperimentalandcontrolgroups(n=30pergroup).TheexperimentalgroupreceivedImprovedZhiliFangacupuncturetreatment,whilethecontrolgroupreceivedconventionalacupuncturetreatment.

Theresultsofthestudyshowedthattheexperimentalgrouphadsignificantlybetteroutcomesthanthecontrolgroupintermsofpainrelief,sensoryfunction,andqualityoflife(P<0.01).Furthermore,theresultsshowedthatImprovedZhiliFangacupuncturetreatmentwaseffectiveinthemanagementofchemotherapy-inducedperipheralneuropathy,andhadnoadverseeffects.

Inconclusion,ImprovedZhiliFangacupuncturetreatmentisaneffectivetherapyforthemanagementofchemotherapy-inducedperipheralneuropathy.Thistherapyhasahightherapeuticefficacyandcansignificantlyimprovethequalityoflifeofpatients.Therefore,theuseofImprovedZhiliFangacupuncturetreatmentshouldbepromotedinclinicalapplicationsforthemanagementofchemotherapy-inducedperipheralneuropathy.FurtherresearchisneededtoexplorethemechanismsofactionofthistherapyandtooptimizeitsuseChemotherapy-inducedperipheralneuropathy(CIPN)isacommonanddistressingsideeffectofchemotherapy,affectingupto70%ofcancerpatientsreceivingchemotherapy(Sakuraietal.,2014).CIPNischaracterizedbyarangeofsensory,motor,andautonomicsymptoms,includingpain,numbness,tingling,weakness,andimpairedbalanceandcoordination(Kottschadeetal.,2011).Theexactmechanismsbywhichchemotherapyinducesperipheralneuropathyarenotfullyunderstood,butitisthoughttoinvolvedamagetotheperipheralnervesandtheirsupportingstructures,leadingtosensoryandmotordysfunction(Krukowskietal.,2016).

VariouspharmacologicalinterventionshavebeenusedtomanageCIPN,includinganalgesics,antidepressants,anticonvulsants,andtopicalagents(Pachmanetal.,2018).However,thesetreatmentsoftenhavelimitedefficacyandareassociatedwithadverseeffects,suchassedation,nausea,andcognitiveimpairment(Rowbothametal.,2014).Therefore,thereisaneedforalternativetherapiesthatcaneffectivelyalleviatethesymptomsofCIPNwithminimalsideeffects.

AcupunctureisatraditionalChinesemedicinetechniquethatinvolvestheinsertionofthinneedlesintospecificpointsonthebodytostimulatetheflowofenergyor"Qi"(Leeetal.,2021).Acupuncturehasbeenwidelyusedforthemanagementofpainandothersymptomsassociatedwithvariousmedicalconditions,includingneuropathicpain(Dingetal.,2019).ImprovedZhiliFangacupuncturetreatmentisamodifiedformofacupuncturethatcombinestraditionalacupuncturewithelectricalstimulationandmoxibustiontherapy(Luetal.,2018).Thistherapyhasbeenshowntohaveahightherapeuticefficacyinthemanagementofvariouskindsofneuropathicpain,includingdiabeticneuropathy,trigeminalneuralgia,andpostherpeticneuralgia(Luetal.,2018).

SeveralstudieshaveinvestigatedtheuseofacupunctureforthemanagementofCIPN,andtheresultssuggestthatacupuncturecanbeaneffectivetherapyforthiscondition(Liuetal.,2017;Zhaoetal.,2017).ArandomizedcontrolledtrialconductedbyLiuetal.(2017)evaluatedtheeffectsofacupunctureonCIPNinpatientswithbreastcancer.Thestudyparticipantsreceivedeitherrealacupunctureorshamacupunctureforeightweeks.Theresultsshowedthatrealacupuncturesignificantlyimprovedthepatients'symptomsofCIPN,includingpain,numbness,andtingling,comparedtoshamacupuncture.AnotherrandomizedcontrolledtrialconductedbyZhaoetal.(2017)comparedtheeffectsofacupunctureandpregabalin,acommonlyusedanticonvulsantforneuropathicpain,onCIPNinpatientswithlungcancer.Thestudyparticipantsreceivedeitheracupuncture,pregabalin,orplacebofor12weeks.Theresultsshowedthatacupunctureandpregabalinwerebotheffectiveinreducingthepatients'symptomsofCIPN,butacupuncturehadfeweradverseeffectsthanpregabalin.

ThemechanismsbywhichacupuncturealleviatesCIPNarenotfullyunderstood,butseveralhypotheseshavebeenproposed.Acupuncturemaymodulatethereleaseofneurotransmittersandcytokinesinvolvedinpainandinflammation,leadingtoareductioninpainperception(Dingetal.,2019).Acupuncturemayalsopromotetheregenerationandrepairofdamagednervesbyincreasingbloodflowandoxygenationtotheaffectedarea(Liuetal.,2017).Additionally,acupuncturemayhaveaneuroprotectiveeffectbyreducingoxidativestressandinflammationintheperipheralnerves(Zhaoetal.,2017).

Inconclusion,acupuncture,particularlyImprovedZhiliFangacupuncturetreatment,isaneffectivetherapyforthemanagementofCIPN.AcupuncturecansignificantlyimprovethesymptomsofCIPNwithminimalsideeffectsandmayhaveaneuroprotectiveeffect.Therefore,theuseofacupunctureshouldbepromotedinclinicalapplicationsforthemanagementofCIPN.FurtherresearchisneededtoexplorethemechanismsofactionofacupunctureandtooptimizeitsuseAdditionally,itshouldbenotedthatacupunctureisarelativelysafetherapywithfewadverseeffects.However,itshouldonlybeperformedbylicensedacupuncturiststoensurepropertechniqueandhygienetominimizetheriskofinfectionorinjury.Patientswithbleedingdisordersortakinganticoagulantmedicationsshouldalsoexercisecautionwhenconsideringacupuncture.

WhileacupunctureshowspromisingresultsforthemanagementofCIPN,itisimportanttonotethatitshouldnotbeusedasasubstituteforconventionalmedicaltreatment.Patientsshouldcontinuetofollowtheirprescribedmedicationregimenanddiscusstheuseofacupuncturewiththeirhealthcareprovider.

Inconclusion,