SGC3027-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemESGC3027Cat.No.:HY-112445CASNo.:2624313-13-7分?式:C??H??ClN?O?S分?量:787.37作?靶點(diǎn):HistoneMethyltransferase作?通路:Epigenetics儲存?式:Powder-20°C3yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:250mg/mL(317.51mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM1.2701mL6.3503mL12.7005mL5mM0.2540mL1.2701mL2.5401mL10mM0.1270mL0.6350mL1.2701mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲存時，請?jiān)?個?內(nèi)使?，-20°C儲存時，請?jiān)?個?內(nèi)使?。BIOLOGICALACTIVITY?物活性SGC3027?種組蛋?甲轉(zhuǎn)移酶抑制劑[1]。SGC3027第?個有效，選擇性，具有細(xì)胞活性的PRMT7化學(xué)探針[2]。IC50&TargetPRMT7[1][2]體外研究SGC3027isapro-drugofSGC8158whichreleasestheactivecomponentuponreductioninthecellby1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEreductases.IncellularassaysusingC2C12cells,SGC3027inhibitsthemethylationofHSP70withIC50=1.3μM[2].戶使?本產(chǎn)品發(fā)表的科研?獻(xiàn)?MolCell.2021Aug5;81(15):3171-3186.e8.?NatCommun.2021Mar29;12(1):1946.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].CermakovaK,etal.Next-GenerationDrugsandProbesforChromatinBiology:FromTargetedProteinDegradationtoPhaseSeparation.Molecules.2018Aug6;23(8).pii:E1958.[2].SGC3027forPRMT7.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax: