O-304-DataSheet-生命科學試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEO-304Cat.No.:HY-112233CASNo.:1261289-04-6分?式:C??H??Cl?N?O?S分?量:380.25作?靶點:AMPK作?通路:Epigenetics;PI3K/Akt/mTOR儲存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實驗DMSO:30mg/mL(78.90mM;Needultrasonicandwarming)MassSolvent1mg5mg10mgConcentration制備儲備液1mM2.6298mL13.1492mL26.2985mL5mM0.5260mL2.6298mL5.2597mL10mM0.2630mL1.3149mL2.6298mL請根據(jù)產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲存時，請在6個?內使?，-20°C儲存時，請在1個?內使?。體內實驗請根據(jù)您的實驗動物和給藥?式選擇適當?shù)娜芙?案。以下溶解?案都請先按照InVitro?式配制澄的儲備液，再依次添加助溶劑：(為保證實驗結果的可靠性，澄的儲備液可以根據(jù)儲存條件，適當保存；體內實驗的?作液，建議您現(xiàn)?現(xiàn)配，當天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的?式助溶)1.請依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(6.57mM);Clearsolution1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEBIOLOGICALACTIVITY?物活性O-304?種?創(chuàng)的，具有?服活性的泛AMPK激活劑，可通過抑制pAMPK的去磷酸化來增加AMPK活性。O-304可?于2型糖尿病和相關??管并發(fā)癥的研究。IC50&TargetAMPK[1]體內研究O-304increasesglucoseuptakeinskeletalmuscle,reducedβcellstress,andpromotedβcellrestindiet-inducedobesemice.O-304reducesfastingplasmaglucoselevelsandhomeostasismodelassessmentofinsulinresistance(HOMA-IR)inaproof-of-conceptphaseIIaclinicaltrialintype2diabetes(T2D)patientsonMetformin[2].戶使?本產品發(fā)表的科研?獻?BiochemJ.2022Jun7;BCJ20220170.?BiochemJ.2021Oct20;BCJ20210411.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].PeriodicReportingforperiod1-AMPK-DIAB(AsmallmoleculeAMPactivatedproteinkinase(AMPK)activator,denotedO304,asanovelinnovativedrugforthetreatmentoftype2diabetes).McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792