NAMPT-inhibitor-linker-1-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemENAMPTinhibitor-linker1Cat.No.:HY-112615CASNo.:2241019-57-6分?式:C??H??FN?O?分?量:668.71作?靶點(diǎn):Drug-LinkerConjugatesforADC作?通路:Antibody-drugConjugate/ADCRelated儲(chǔ)存?式:-20°C,storedundernitrogen*Insolvent:-80°C,6months;-20°C,1month(storedunder

nitrogen)溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:37.5mg/mL(56.08mM;ultrasonicandwarmingandheatto60°C)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM1.4954mL7.4771mL14.9542mL5mM0.2991mL1.4954mL2.9908mL10mM0.1495mL0.7477mL1.4954mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；?旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲(chǔ)備液的保存?式和期限：-80°C,6months;-20°C,1month(storedundernitrogen)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?。BIOLOGICALACTIVITY?物活性NAMPTinhibitor-linker1為ADC的?部分，由?種NAMPT的抑制劑作為有效載荷和?個(gè)連接物組成。ADC-3由?個(gè)NAMPTinhibitor-linker1和?個(gè)anti-c-Kit單克隆抗體組成，對(duì)表達(dá)c-Kit的細(xì)胞具有抑制作?，?如GIST-T1和NCI-H526細(xì)胞，IC50值分別為[1]。IC50&TargetTraditionalCytotoxicAgents體外研究ADC-3exihibitspotentactivityagainstc-KitexpressingcelllinessuchasGIST-T1andNCI-H526,withIC50s1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEof[1].體內(nèi)研究ADC-3(20mg/kg,i.v.for28days)istolerated,andcausestumorstasisinmicebearingGIST-T1cells[1].AnimalModel:Femalescid-beige(SCIDbg)mice[1]Dosage:20mg/kgAdministration:Asingleintravenousinjection(i.v.)for28daysResult:Significantlyinhibitedthegrowthoftumorinmice.REFERENCES[1].KarpovAS,etal.NicotinamidePhosphoribosyltransferaseInhibitorasaNovelPayloadforAntibody-DrugConjugates.ACSMedChemLett.2018Jun28;9(8):838-842.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-