AOC第一章有機反應基本原理

AdvancedOrganicChemistryZhulili1985年，出生于湖北天門2004-2008年，西南大學化學化工學院2008-2013年，中國人民大學化學系2013至今，周口師范學院講師。SelfIntroductionResearchInterest：OrganicSynthesis&OrganicReactionMethodology（1）金催化的一些新合成方法學的研究。（2）區(qū)域選擇性N2烷基三唑的合成方法學研究。

電話有機化學有用有機合成物理有機有機分析合成一個新世界有機化學該怎么學？？？學習有機化學的難點：多，雜，規(guī)律性差是不是這個原因讓人望而生畏，不全是!!!!!!有哪一種科學比記GRE單詞更多，更雜，更沒有規(guī)律性？？文獻：<<Science>>,<<Nature>>與有機化學有關(guān)的一些期刊ACS系列:JournalofAmericanChemicalSocietyJournalofOrganicChemistryOrganicLettersOrganometallicsWieley系列:AngewChemieInternationaleditionChemistry,AEuropeanJournalChemistry,AAsianJournalEuropeanJournaloforganicChemistry

Rsc系列：ChemicalScience,ChemicalCommunicationElsevier系列：TetrahedronTetrahedronLettersTetrahedronAsymmetry檢索工具：ScienceFinderBeilsteinCrossfireWebofScience有機化學的研究方法，學習方法

chemistry學習方法：youshouldremembersthinorganicchemistry,justlikestudyingalanguage.Howtolearn<<AdvancedOrganicChemistry>>.Thebasicrequirment:trytounderstandeachfigure,andtellyourselfwhatisgoingon.RememberBasicReactionsandtheirmechanismThereareseveralgeneralreactiontypesinorganictransformation,suchas:radicalreaction,polarreaction,andmetalcatalyzedreaction.

Therearesomeuniversaleffectsgoverningchemicalreactions,suchas:stericeffect,electroniceffect,etc.Trytoexplainthereactionphenomenonusingdifferentreactiontypesanddifferentreactionfactors.Trytopredictsomenewreaction,andthenverifyorfalsifyitthroughexperiments.

AccomplishmentsoforganicsynthesisinthetwentiethcenturyR.B.Woodward1917-1979介紹一些有機合成化學的大師1965NobelPrizeWinner.“forhisoutstandingachievementsintheartoforganicsynthesis.”SelectedsynthesesbytheWoodwardGroup(1944-1981).Ref:Angew.Chem.Int.Ed.2000,39,44–122.…Coreyhasthusbeenawardedwiththe1990nobelPrizeforthreeintimatelyconnectedcontributions,whichformawhole.Throughretrosyntheticanalysisandintroductionofnewsyntheticreactions,hehassucceededinpreparingbiologicallyimportantnaturalproducts,previouslythoughtimpossibletoachieve.Corey’scontributionshaveturnedtheartofsynthesisintoascience…NobelLectures:Chemistry1981-1990,WorldScientific,NewJersey,1992,pp677-708.E.G.Corey1928-TheNobelPrizeinChemistry2001ThesuccessofasymmetrichydrogenationlargelyusingBINAP-Rucomplexandits’extensiveusefulnessinindustry.RyojiNoyori1938-介紹一些有機合成方法學的大師TheNobelPrizeinChemistry2001

Thesuccessofasymmetricepoxidationandasymmetricdihydroxyaltionofthealkene.K.BarrySharpless1941-TheNobelPrizeinChemistry2005goestoYvesChauvin,RobertH.GrubbsandRichardR.Schrock"forthedevelopmentofthemetathesismethodinorganicsynthesis".OlefinMetathesis/GrubbsReaction:OlefinMetathesisallowstheexchangeofsubstituentsbetweendifferentolefins-atransalkylidenation.

CouplingReactionTheRoyalAcademyofSciencesannouncestheNobelPrizeinChemistry2010awardedjointlyto(portraitsseenonscreenfromleft)USA'sRichardF.Heck,JapaneseEi-ichiNegishiandAkiraSuzukiinStockholmonOctober6,2010.RichardHeckoftheUnitedStatesandJapan'sEi-ichiNegishiandAkiraSuzukisharedthe2010NobelChemistryPrizeWednesdayforpioneeringresearchinlinkingcarbonatoms.TheRoyalSwedishAcademyofScienceslaudedthetrio'sworkin"thedevelopmentofpalladium-catalyzedcrosscoupling."我所希望的教學模式課堂的教學學生課后的反饋Referencebook：《AdvancedOrganicChemistry》PartA:StrutureandMechanismsPartB:ReactionsandSynthesis

FrancisA.Carey&RichardJ.Sundberg高等有機化學-------反應與機理BernardMiller吳范宏譯華東理工大學出版社現(xiàn)代有機反應(五卷)

胡躍飛林國強主編化學工業(yè)出版社1，有機反應的基本原理（2）2，取代基效應（5）3，取代、加成反應（8,9,11,12）4，消去反應（10）5，氧化還原反應（13）6，重排反應（15）7，周環(huán)反應（16）考核辦法：平時成績（10%）+作業(yè)（20%）+期末成績（70%）Tellmewhathappenedifyouarenotavailable!!Makeagoodhomework!Thisisdefinitelyyouredge！第二章有機反應的基本原理一、反應的分類（1）按反應歷程自由基反應：通過共價鍵的均裂而進行的反應。自由基反應一般在光或熱的作用下進行。離子型反應：通過共價鍵的異裂而進行的反應。離子型反應一般在酸、堿等極性試劑的作用下進行。它又分為親核反應和親電反應。協(xié)同反應：舊鍵的斷裂和新鍵的生成是同時進行的。（2）按原料和產(chǎn)物取代反應：鹵代