NKL-22-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemENKL22Cat.No.:HY-100384CASNo.:537034-15-4分?式:C??H??N?O?分?量:325.4作?靶點(diǎn):HDAC作?通路:CellCycle/DNADamage;Epigenetics儲(chǔ)存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:100mg/mL(307.31mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM3.0731mL15.3657mL30.7314mL5mM0.6146mL3.0731mL6.1463mL10mM0.3073mL1.5366mL3.0731mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；?旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲(chǔ)備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?。BIOLOGICALACTIVITY?物活性NKL22(化合物4b)?種有效的選擇性組蛋?脫?酰酶(HDAC)抑制劑，抑制HDAC1和HDAC3的IC50值分別為199和69nM。NKL22對(duì)HDAC2/4/5/7/8(IC50≥1.59μM)具有選擇性。NKL22改了亨廷頓?病轉(zhuǎn)因??的疾病表型和轉(zhuǎn)錄異常。IC50&TargetHDAC1HDAC2HDAC3HDAC81/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE0.199μM(IC50)1.59μM(IC50)0.069μM(IC50)5μM(IC50)戶使?本產(chǎn)品發(fā)表的科研?獻(xiàn)?JMolMed(Berl).2019Aug;97(8):1183-1193.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].DHermanetal.HistonedeacetylaseinhibitorsreversegenesilencinginFriedreich'sataxia.NatChemBiol,2006Oct,2(10):551-8.[2].JiaH,et,al.Histonedeacetylase(HDAC)inhibitorstargetingHDAC3andHDAC1amelioratepolyglutamine-elicitedphenotypesinmodelsystemsofHuntington'sdisease.NeurobiolDis.2012May;46(2):351-61.[3].ThomasEA,et,al.TheHDACinhibitor4bamelioratesthediseasephenotypeandtranscriptionalabnormalitiesinHuntington'sdiseasetransgenicmice.ProcNatlAcadSciUSA.2008Oct7;105(40):15564-9.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-5