Linaprazan-AZD0865-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemELinaprazanCat.No.:HY-100412CASNo.:248919-64-4Synonyms:AZD0865分?式:C??H??N?O?分?量:366.46作?靶點(diǎn):ProtonPump作?通路:MembraneTransporter/IonChannel儲(chǔ)存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:≥35mg/mL(95.51mM)*"≥"meanssoluble,butsaturationunknown.MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM2.7288mL13.6441mL27.2881mL5mM0.5458mL2.7288mL5.4576mL10mM0.2729mL1.3644mL2.7288mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；?旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲(chǔ)備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?。BIOLOGICALACTIVITY?物活性Linaprazan(AZD0865)能夠通過(guò)K+競(jìng)爭(zhēng)約束抑制胃?H+,K+-ATPase.(IC50:1.0±0.2μM)，它對(duì)酸有很強(qiáng)的抑制作?。1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEREFERENCES[1].GeddaKetal.MechanismofactionofAZD0865,aK+-competitiveinhibitorofgastricH+,K+-ATPase.BiochemPharmacol.2007Jan15;73(2):198-205.[2].KahrilasPJetal.Arandomized,comparativestudyofthreedosesofAZD0865andesomeprazoleforhealingofrefluxesophagitis.ClinGastroenterolHepatol.2007Dec;5(12):1385-91.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:021-53700