Synaptamide-Dehydroepiandrosteron-DHEA-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemESynaptamideCat.No.:HY-100197CASNo.:162758-94-3Synonyms:Dehydroepiandrosteron(DHEA);Docosahexaenoylethanolamide分?式:C??H??NO?分?量:371.56作?靶點(diǎn):CannabinoidReceptor作?通路:GPCR/GProtein;NeuronalSignaling儲存?式:Solution,-20°C,2years*Insolvent:-80°C,6months;-20°C,1month(2years)溶解性數(shù)據(jù)體外實(shí)驗(yàn)Ethanol:25mg/mL(67.28mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM2.6914mL13.4568mL26.9136mL5mM0.5383mL2.6914mL5.3827mL10mM0.2691mL1.3457mL2.6914mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲存時，請?jiān)?個?內(nèi)使?，-20°C儲存時，請?jiān)?個?內(nèi)使?。BIOLOGICALACTIVITY?物活性Synaptamide(Dehydroepiandrosteron;DHEA)?種內(nèi)性代謝物，Anandamide的結(jié)構(gòu)類似物。Synaptamide與??素-1和2(CB1和CB2)??素受體結(jié)合并具有抗炎特性。Synaptamide第?個粘附G蛋?偶聯(lián)受體(aGPCR)的?分?內(nèi)性配體。體外研究Synaptamide(Dehydroepiandrosteron;DHEA)isaweakagonistatbothCB1andCB2receptors[2].1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE體內(nèi)研究Synaptamide(10mg/kg;subcutaneously;dailyfor7days)promotescognitiverecoveryinratssubjectedtomildtraumaticbraininjury(mTBI)[1].Synaptamide(2-10mg/kg;adultmaleC57BL/6Jmice)reducedthelevelsofnociceptiveandinflammatorypain-relatedbehaviourover60minintheintraplantarformaldehydeassayviabothintraperitonealandlocalintraplantaradministration[2].AnimalModel:MaleWistarrats;260?±?20g,age3months;mTBImodel)[1]Dosage:10mg/kgAdministration:Subcutaneously;dailyfor7daysResult:ReversedthemTBI-inducedcognitivedeficits.戶使?本產(chǎn)品發(fā)表的科研?獻(xiàn)?EcotoxicolEnvironSaf.2021Feb25;214:112005.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].KimHY,etal.Synaptamide,endocannabinoid-likederivativeofdocosahexaenoicacidwithcannabinoid-independentfunction.ProstaglandinsLeukotEssentFattyAcids.2013Jan;88(1):121-5.[2].RashidMA,etal.N-Docosahexaenoylethanolamineisapotentneurogenicfactorforneuralstemcelldifferentiation.JNeurochem.2013Jun;125(6):869-84.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.