免疫學課程教學大綱

免疫學課程教學大綱CourseOutline課程基本信息（CourseInformation）課程代碼（CourseCode）

MS310

*學時64t

*學分（Credits）

4.0*課程名稱（CourseTitle）*課程性質(zhì)（CourseType）授課對象（TargetAudience）*授課語言(LanguageofInstruction)*開課院系先修課程授課教師

（中文）免疫學（英文）PrincipleofImmunobiology本科二年級/三年級雙語（漢語+英語）蘇冰

選修課課程網(wǎng)址（Instructor）

(CourseWebpage)*）些主要的實驗手段。并介紹其同其它生命學科的密切相關性，和其研究的方法。學生物學知識的生物工程學專業(yè)的學生。Thiscourseisahalf-yearcoursewhichintroducesthebasicprinciplesofmodernimmunobiology.Itwillfocusonthegeneration,developmentandregulationoftheimmunesystemanditsfunctioninhumanepidemics,immunologicaldiseases,inflammationandtumor.Theaimofthiscourseisnotonlytoelucidatethesekeyprinciplesofimmunology,butalsotodiscussitshistoryofdiscoveryandsomemajor*）

experimentaltechniques.Thecoursewillalsointroducethecloserelationshipofimmunologytotheothersubdisciplinesoflifescienceandresearchmethods.Thiscourseisnotonlysuitableforthestudentswhomajorsinlifescienceormedicalscience,butisalsogoodforthestudentswhomajorinbiomedicalengineeringwhowanttopickupsomebasicknowledgeinimmunology.課程教學大綱（coursesyllabus）免疫系統(tǒng)組成和功能。Introductiontotheimmunesystem.理解免疫細胞的免疫學功能。Describeinnateimmunerecognition.UnderstandInflammation,infectionandacutephaseresponses.DiscussimmunologicalFunctionofinnateimmunecells,suchasmonocyte,macropahgeandDC,etc.T,B淋巴細胞的發(fā)育，了解淋巴細胞抗原受體基因結(jié)構(gòu)和V(D)J排。DescribethedevelopmentofTandBcells.RecognizetheTCRandBCRgenestructuresandV(D)Jrearrangement.TTT細胞激活和T細胞亞群的分化及T細胞的功能。DescribeTCellreceptorandantigenrecognition.UnderstandTlymphocytematurationandmigrationintheLymphoidOrgans.DescribeTcellactivation,differentiationandthefunctionofeffectorTcells.*學習目標(LearningOutcomes)

認識B細胞介導的免疫應答和生發(fā)中心的反應，理解Ig類別轉(zhuǎn)換、體細胞高頻突變和抗體親和力成熟認識免疫球蛋白分子結(jié)構(gòu)分類和功能Recognize B cell mediated immune response and germinal center reacyion.UnderstandIgclassswitch,somatichypermutationandaffinitymaturation.Describethestructure,classificationandfunctionofimmunoglobulin.B和TRecognizeandcomparethedifferenceofBCRandTCRsignaltransduction.Recognizethecytokinesandsignalingpathways.MHCMHCIII類分子抗原提呈的區(qū)別。DescribeMHCgeneandstructure.ComparethedifferenceofMHCImoleculeandMHCIImoleculepresentingantigen.記憶，了解疫苗的功能。Recognizeimmuneevolution. Understandtheinductionoftheadaptiveimmunitybyinnateimmuneresponseandimmunologicalmemory.Describethefunctionofvaccine.認識黏膜免疫的組成和功能。Recognizemucosalimmunesystemandmucosalimmunity.認識抗感染免疫的具體機制。Recognizeimmuneresponsetoinfection(virus,fungi,bacteria).認識腫瘤免疫逃逸及機體抗腫瘤免疫。Understandtheimmunologicalprinciplesoftumorimmuneescape,anti-tumorimmunity.理解移植排斥的免疫學原理。Understandtheimmunologicalprinciplesoftransplantrejection.認識免疫缺陷，認識自身免疫病的病理損傷機制和相關治療。Recognizeimmunodeficiency.Understandpathologicaldamagemechanismandtherapeuticprincipleofautoimmunedisease(suchasSLE、RA、Diabetesetc.).教學內(nèi)容Introductiontothe

學時 教學方式 作業(yè)及要求基本要求 考查方式ImmuneSystemInnateImmuneSystemInnateImmuneRecognition4課堂教學預復習andInflammationDevelopmentof6課堂教學預復習LymphocytesAdaptiveImmuneReceptorand4課堂教學預復習AntigenRecognitionTCRandBCRsignal4課堂教學預復習transductionGenerationandRegulationof4課堂教學預復習AdaptiveImmunityMHCandAntigen8課堂教學預復習Presentation*教學內(nèi)容、進度安排及要求(ClassSchedule&Requirements)2課堂教學預復習10課堂教學2課堂教學預復習10課堂教學預復習10課堂教學預復習ImmunityandAdaptiveImmunity,MemoryTheImmuneSysteminHealthandDisease*考核方式(Grading)*教材或參考資料(Textbooks&OtherMateri