BAY-8400-DataSheet-生命科學試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEBAY-8400Cat.No.:HY-132293分?式:C??H??F?N?O分?量:393.39作?靶點:DNA-PK作?通路:CellCycle/DNADamage;PI3K/Akt/mTOR儲存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實驗DMSO:62.5mg/mL(158.88mM;ultrasonicandwarmingandheatto60°C)MassSolvent1mg5mg10mgConcentration制備儲備液1mM2.5420mL12.7100mL25.4201mL5mM0.5084mL2.5420mL5.0840mL10mM0.2542mL1.2710mL2.5420mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲存時，請在6個?內(nèi)使?，-20°C儲存時，請在1個?內(nèi)使?。體內(nèi)實驗請根據(jù)您的實驗動物和給藥?式選擇適當?shù)娜芙?案。以下溶解?案都請先按照InVitro?式配制澄的儲備液，再依次添加助溶劑：(為保證實驗結(jié)果的可靠性，澄的儲備液可以根據(jù)儲存條件，適當保存；體內(nèi)實驗的?作液，建議您現(xiàn)?現(xiàn)配，當天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的?式助溶)1.請依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.08mg/mL(5.29mM);Clearsolution1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEBIOLOGICALACTIVITY?物活性BAY-8400?種?服活性、有效和選擇性DNA依賴蛋?激酶(DNA-PK)抑制劑(IC50=81nM)。BAY-8400可?于癌癥研究[1]。IC50&TargetIC50:81nM(DNA-PK)[1]體內(nèi)研究BAY-8400(150mg/kg;p.o.)increasestheantitumorefficacy.BAY-8400showsusefulaqueoussolubilityandoralbioavailabilityacrossspecies[1].REFERENCES[1].BergerM,etal.BAY-8400:ANovelPotentandSelectiveDNA-PKInhibitorwhichShowsSynergisticEfficacyinCombinationwithTargetedAlphaTherapies[publishedonlineaheadofprint,2021Aug24].JMedChem.2021;10.1021/acs.jmedchem.1c00762.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-58955