Clobetasone-butyrate-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?Agonists?ScreeningLibrarieswww.MedChemEClobetasonebutyrateCat.No.:HY-B1616CASNo.:25122-57-0分?式:C??H??ClFO?分?量:478.98作?靶點(diǎn):GlucocorticoidReceptor作?通路:GPCR/GProtein儲(chǔ)存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:≥250mg/mL(521.94mM)*"≥"meanssoluble,butsaturationunknown.MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM2.0878mL10.4388mL20.8777mL5mM0.4176mL2.0878mL4.1755mL10mM0.2088mL1.0439mL2.0878mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存?式和期限。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥?式選擇適當(dāng)?shù)娜芙?案，配制前請(qǐng)先配制澄的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分?指該溶劑在您配制終溶液中的體積占?)：1.請(qǐng)依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥6.25mg/mL(13.05mM);ClearsolutionBIOLOGICALACTIVITY1/2MasterofSmallMolecules—您?邊的抑制劑?師www.MedChemE?物活性Clobetasonebutyrate?種糖?質(zhì)類醇(glucocorticoid)，具有局部抗炎活性，尤其在?膚上。Clobetasonebutyrate可?于緩解?質(zhì)類醇反應(yīng)性癥狀，包括特應(yīng)性?炎和??癬。IC50&TargetIC50:glucocorticoid[1]體內(nèi)研究Clobetasonebutyrate(applicationontheskin;0.05%;7weeks)inducesepidermalthinninginskin,Clobetasonebutyrate7weekscausesmuchlessepidermalthinninginthepigthanflurandrenolone(0.05%)orfluocinoloneacetonide(0.025%),bothofwhichcausessevereatrophy[1].AnimalModel:Largewhitedomesticpig[1]Dosage:0.5%applicationontheskinAdministration:7weeksResult:Causedmoderatetoslightatrophy.REFERENCES[1].MunroDD,etal.Clobetasonebutyrate,anewtopicalcorticosteroid:clinicalactivityandeffectsonpituitary-adrenalaxisfunctionandmodelofepidermalatrophy.[2].MichaelStewart,etal.Clobetasonebutyrateforinflammatoryskinconditions.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792