目前國(guó)際最新制劑發(fā)展動(dòng)態(tài)及加工關(guān)鍵技術(shù)介紹-先正達(dá)課件

1、Agrochemical Formulation Trends農(nóng)藥制劑的發(fā)展趨勢(shì)CCPIAGuilin, Guangxi, China中國(guó) 桂林Keith Parker, Ph.D.Syngenta Asia Pacific Pte. Ltd.Who is Syngenta 先正達(dá)介紹Agrochemical Formulation Trends農(nóng)業(yè)化學(xué)配方的發(fā)展趨勢(shì)Contents 內(nèi)容Our industry family tree 國(guó)際農(nóng)化公司發(fā)展概況CibaSandozICIISK BiosciencesMonsantoDuPontShellCyanamidBASFBayerRhone

2、-PoulencHoechstScheringDowRohm & HaasMerck1992199319941995199619971998199920002001NovartisAHPAventis2002AgrevoZenecaExcellent complementary and leading product portfolio卓越全面、領(lǐng)先的產(chǎn)品線 A leader in crop protection 植保領(lǐng)域的領(lǐng)先者 Third in high-value commercial seeds 高價(jià)值商業(yè)種子排名第三First class research and developme

3、nt resources 一流的研發(fā)資源 Investment of around $800m annually 每年投入約八億美元Strong worldwide presence 業(yè)務(wù)遍布全球 Around 21,000 employees in over 90 countries 在90多個(gè)國(guó)家擁有2萬(wàn)1千名雇員Rich pipeline of Crop Protection and Seeds products豐富的植保和種子產(chǎn)品產(chǎn)銷渠道Syngenta a leading global agribusiness先正達(dá)全球領(lǐng)先的農(nóng)業(yè)科技公司Syngenta a leading glob

4、al agribusiness先正達(dá)全球領(lǐng)先的農(nóng)業(yè)科技公司 million tonnes of cotton is grown using our crop protection products全球440萬(wàn)噸棉花種植過(guò)程中使用先正達(dá)植保產(chǎn)品Thats the equivalent of 20 billion T-Shirts這相當(dāng)于200億件T恤的用料4.4What We Do 我們從事哪些業(yè)務(wù)Crop Protection作物保護(hù)Seeds種子 Professional Products專業(yè)產(chǎn)品 Bio-technology生物技術(shù) Major product brands 主要的產(chǎn)品品牌

5、Herbicides 除草劑Professional products 專業(yè)產(chǎn)品Fungicides 殺菌劑Insecticides 殺蟲(chóng)劑Seeds 種子 阿克泰金雷世高阿米西達(dá)銳勝泰草達(dá)克無(wú)蹤功夫千層紅Major R&D sites located at theheart of scientific communitiesOther sitesMarker-assisted and seed breeding capabilitiesGlobal field station networkGlobal R&D capabilities 全球研發(fā)機(jī)構(gòu)美國(guó)格林斯博羅GREENSBOROForm

6、ulationEnvironmental Science美國(guó)SBIBiotechnologyR&D英國(guó)集能山JEALOTTS HILLChemical DiscoveryWeed ControlFormulationBioscienceEnvironmental Science瑞士巴塞爾/斯坦恩BASEL/STEINFungicides, Insecticides &Professional Products印度果阿GOAChemistrySyngenta in China 先正達(dá)在中國(guó)Crop Protection作物保護(hù)Seeds 種子 Professional Products專業(yè)產(chǎn)品

7、R&D研發(fā)A history of more than 100 years 百多年合作歷史 Associated investment US$ 200m 目前總投資達(dá)2億美元 40% of the total direct foreign investment in CP section投資額占中國(guó)市場(chǎng)植保領(lǐng)域外商直接投資的40Investment in China 先正達(dá)在中國(guó)的投資Syngenta (Suzhou) Crop Protection Co., Ltd.Syngenta Seeds Company Ltd.Syngenta Nantong Crop Protection Co.

8、, Ltd.Chinas sustainable agriculture development through innovative research and technology通過(guò)創(chuàng)新性的研究和技術(shù)，中國(guó)農(nóng)業(yè)的可持續(xù)性發(fā)展Improve crop productivity, quality and safety through integrated solutions通過(guò)完整的方案，提高和改善作物產(chǎn)量，質(zhì)量和安全性Upgrade Chinese farmers income and the quality of life提升中國(guó)農(nóng)民的收入和生活質(zhì)量Syngenta China is Co

9、mmitted To先正達(dá)中國(guó)忠于.Who is Syngenta 先正達(dá)介紹Agrochemical Formulation Trends農(nóng)業(yè)化學(xué)配方的發(fā)展趨勢(shì)Contents 內(nèi)容Why Formulation? 為什么要制成制劑使用？Active Ingredients dont work. 原藥本身沒(méi)有藥效.Until they are made into formulations 除非原藥被做成制劑后使用 Our customers buy formulated products in packs我們的客戶購(gòu)買的是包裝好的農(nóng)藥制劑產(chǎn)品Solutions溶液Emulsions乳液Sus

10、pensions懸浮液Solids固體Capsules膠囊Untreated 沒(méi)有使用過(guò)農(nóng)藥Un-Formulated Herbicide 未經(jīng)制劑加工的除草劑Formulated Herbicide 經(jīng)過(guò)配制的除草劑Liquid Formulation SC SL, EC液體制劑 水懸浮劑、可溶性液劑、乳油Concentrated Flowable具流動(dòng)性的濃縮產(chǎn)品On dilution稀釋過(guò)程(SC: suspension concentrate; SL: soluble concentrate; EC: Emulsifiable concentrate Solid Formulation

11、s WP WG 固體制劑 可濕粉、水分散粒劑WP: Wettable Powder可濕性粉劑WG水分散粒劑 WG (Pepite)WPWG: Water Dispersible Granule 水分散粒劑 可濕性粉劑Wettable powder 可濕性粉劑application in Egypt circa 1980應(yīng)用在埃及 大約在1980Agricultural formulations can be very sophisticated農(nóng)藥制劑具有悠久的歷史trigger ruptures weak linkfor fast release at right place / timeT

12、riggered release觸發(fā)釋放Polymer layers聚合物層First generation第一代New surface properties新表面特性Anionic陰離子Cationic陽(yáng)離子Liquid液體+-Improved handling改善操作Targeted activity 活性目標(biāo)Differentiated products 產(chǎn)品多樣化New markets 新市場(chǎng)Extended patent protection 擴(kuò)大專利保護(hù)范圍Zeon is a Reg. trademark觸發(fā)劑割裂脆弱處在合適的時(shí)間/地點(diǎn)釋放What do Companies th

13、ink? 公司在考慮什么？ “Product innovation using existing active ingredients” “運(yùn)用新技術(shù)對(duì)現(xiàn)有的原藥進(jìn)行創(chuàng)新” Combining active ingredients in novel combination products drives innovation. 運(yùn)用新技術(shù)，對(duì)產(chǎn)品重新配制，以推動(dòng)創(chuàng)新。Novel formulation technology enables new products from existing compounds which have new levels of activity, safety

14、 and spectrum, both as sprayed products and increasingly as seed treatments.利用新的制劑技術(shù)可以使現(xiàn)有的原藥，無(wú)論是用于噴灑還是日益增長(zhǎng)的種子處理劑，成為高效、安全、廣譜的新產(chǎn)品。Bayer annual review: 拜爾年度回顧Formulation know-how translates into competitive edge制劑技術(shù)成為競(jìng)爭(zhēng)的優(yōu)勢(shì)Different technologies are used to formulate the active ingredient into a product

15、 with optimal application properties采用的不同技術(shù)，將原藥配制成具有最佳應(yīng)用性能的產(chǎn)品Syngenta Annual Review 2005 先正達(dá)2005年度回顧Formulation Trends 制劑的發(fā)展趨勢(shì) Increasing complexity 日益復(fù)雜mixtures, AI properties, novel technology,混合制劑，原藥的性能，新型技術(shù)Continued regulatory pressure (environment)持續(xù)的法規(guī)壓力（環(huán)境）cost pressures 成本壓力Formulation diffe

16、rentiation increasingly important to agri business 制劑的多樣性對(duì)農(nóng)業(yè)行業(yè)日益重要Formulation Research : Historic View 制劑技術(shù)研究：歷史回顧1970s2000s1990s1980sECs and WPs乳油和可濕性粉劑SCs and EWs水懸浮劑&乳液o/wMicrocapsules微膠囊WGs 水分散顆粒Adjuvants 助劑Novel Physical Forms具有新性能的產(chǎn)品Oil Dispersions油分散產(chǎn)品Safety安全Safety, Environmental and Efficac

17、y安全，環(huán)境和有效Convenience / Safety / Environmental方便/安全/環(huán)境Efficacy 有效Convenience方便Convenience / labile AIs方便/有效成份進(jìn)入植物組織Formulation Benefits 配制成制劑的益處Case studies: 實(shí)例研究Increased biological performance (adjuvants)增強(qiáng)生物性能（助劑）Improved handling and application characteristics 改善操作和應(yīng)用特性Controlled release & enhan

18、ced safety 控制釋放和增強(qiáng)安全性 Increased biological performance 增強(qiáng)生物活性The use of adjuvants may improve the performance or allow a reduced rate of many active ingredients 助劑的使用可以改善應(yīng)用性能或可以降低使用原藥的用量Adjuvants: Improved Efficacy 助劑：改善功效Example : Adjuvant can improve activity by : increasing droplet spreadincreasi

19、ng leaf uptake例如：助劑可以通過(guò)下列方式改善活性增加液滴的擴(kuò)散增加植物葉片的吸收No adjuvant 沒(méi)有助劑With adjuvant 有助劑Novel adjuvant新型助劑Standard adjuvant 標(biāo)準(zhǔn)助劑No adjuvant無(wú)助劑時(shí)間Adjuvancy: the “on-off“ switch for pinoxaden當(dāng)天應(yīng)用未處理沒(méi)有助劑有助劑未處理沒(méi)有助劑有助劑應(yīng)用20天以后Not Just Herbicides! 不只是除草劑 Bayer WOO2098230-fatty alcohol alkoxylates with insecticides拜

20、爾WOO2098230烷氧基脂肪醇與殺蟲(chóng)劑 WO 2003/099012A1 Syngenta 先正達(dá)2003/09912A1 Use of phosphonate adjuvants with insecticides 在殺蟲(chóng)劑中使用磷酸酯做助劑 Exemplified by bis(2-ethylhexyl)-2-ethylhexyl phosphonate (BEEP) 例如：雙（2乙基己基）2乙基己基磷酸酯吸收/轉(zhuǎn)移24小時(shí)后吸收/轉(zhuǎn)移48小時(shí)后吸收/轉(zhuǎn)移死亡率多殺菌素氯芬新 甲氨基阿維菌素苯甲酸鹽 死亡率死亡率吸收/imidacloprid 的轉(zhuǎn)移Improved Handling

21、and Application 改善操作和應(yīng)用Formula M, a new technology in Seed Treatment配方M，在種子處理中的新技術(shù)Treated seeds 種子處理Celest Extra (current) Celest Extra（目前）Celest Extra Formula M Celest Extra 配方MFormula M provides 配方M可以具有 Improved coverage (homogeneity of treatment) 改善覆蓋層（處理均勻性） Improved appearance (stronger colour)

22、 改善外觀（較強(qiáng)的色澤） Reduced human exposure (less dust-off) 減少與人體接觸 （較少脫落） Faster processing of treated seed (faster drying) 加快種子處理過(guò)程 （快速干燥）Less Dust-off : safer product 更少的脫落：更安全的產(chǎn)品Dust-off filter, A8533F 200 mL/100kg on wheat, diluted with 400mL water ST22TA828/03粉塵濾膜，A8533F200ml/100kg，用于小麥。用400ml水稀釋ST22T

23、A828/03Dust-off filter, A8533G 200 mL/100kg on wheat, diluted with 400 mL water ST22TA828/09 濾膜A8533G 200 mL/100kg，用于小麥。 用400ml水稀釋ST22TA828/09Celest Extra (current)目前Celest Extra Formula M 配方M脫落，克/100公斤小麥Higher productivity for treating companies種子處理公司有更高的生產(chǎn)能力Celest 025 FS (current)目前Celest 025 FS f

24、ormula M配方MImprovement of bagging time by 15%!減少15的包裝時(shí)間Controlled Release and Enhanced Safety 控制釋放和增強(qiáng)安全性Karate and Demand: microencapsulation provides many benefits功夫和大滅：微膠囊化可以提供很多好處Microencapsulation (1st Generation) 微膠囊化（第一代）polymericWall聚合物壁Water水Lambda in solvent高效氯氟氰菊脂在溶劑中 UV protectant 紫外線保護(hù)劑D

25、emand High load capacity; safening; environmental高容量；安全；環(huán)保Robust - designed for slow release 可靠-設(shè)計(jì)為緩慢釋放Micro-encapsulation (2nd Generation) 微乳膠囊化（第二代）氯氟氰菊酯微膠囊劑 Improved safety 改善安全性Safer mammalian tox 對(duì)哺乳動(dòng)物更安全Lower solvent levels 更低的溶劑量Improved performance 改善性能Efficacy EC by fast release 功效通過(guò)快速釋放的EC

26、UV protectant 防紫外線保護(hù)劑Lambda DemandParathion-methylLambda ZeonCapsule Suspensions 懸浮劑Capsules suspended in a liquid base giving a flowable suspension concentrate. 膠囊懸浮在液體中，生產(chǎn)出具有流動(dòng)性的懸浮劑Microcapsules 微膠囊Typically 1-20 micron hollow spheres filled with AI通常活性成分被填入120微米的空心球中High load capacity 高容量Aqueous

27、(CS) or dry products水溶液（懸浮液）或固體產(chǎn)品Reservoir儲(chǔ)存囊Matrix母體Control of parameters to vary release rate: 控制參數(shù)以控制釋放速率：particle size 顆粒大小monomer composition單體成分cross-link density鉸鏈密度wall thickness壁厚Stabiliser穩(wěn)定劑polymeric wall聚合物墻壁continuousPhase 連續(xù)相 Active Ingredient活性成分rr”ccConventional Microcapsules Release

28、 by Diffusion Control常規(guī)的微膠囊釋放是由控制擴(kuò)散完成的釋放速率表面積擴(kuò)散濃度墻壁厚度滲透性擴(kuò)撒系數(shù)分配系數(shù)Applications Beyond Conventional Technology新技術(shù)的應(yīng)用Reduced mammalian tox降低哺乳動(dòng)物毒性Targeting against pest Pressure 將害蟲(chóng)作為目標(biāo)的壓力season long control from one application一次施藥可長(zhǎng)期有效Reduced antagonism降低抗性Hours / days / monthsTriggers;觸發(fā)劑pH, light, t

29、emp，pH，光線，溫度 Hours / days / monthsAI seenby target農(nóng)藥有效成份到達(dá)標(biāo)靶EC浮油Microcap微膠囊Hrs / days / mthsExtended release for established benefits延長(zhǎng)有效成份釋放到受藥體research challenges ! 研究挑戰(zhàn)Beneficial insect protection 保護(hù)益蟲(chóng)Chemically Triggered Release Strategy化學(xué)方法觸發(fā)法custom designed weak links are incorporated into the

30、 wall during polymerisation 在聚合過(guò)程中將結(jié)合力較弱的物質(zhì)嵌入內(nèi)壁trigger is activated at chosen moment - ruptures weak link 在合適的時(shí)間，觸發(fā)劑被激活，結(jié)合力較弱處斷裂punctures reduce wall thickness (r-r”) to zero, circumventing the normal diffusion process 滲透物使壁厚變小(r-r”) 到0，打破常規(guī)的正常的擴(kuò)散過(guò)程triggerrupturesweak linkallowingfast releaseweak li

31、nkAIAI觸發(fā)劑可以快速釋放結(jié)合力較弱處裂開(kāi)釋放率結(jié)合力較弱的物質(zhì)Acid Triggered Capsules酸觸發(fā)膠囊Non-triggered沒(méi)有被觸發(fā)的Triggered觸發(fā)的Future Vision: From a Western perspective未來(lái)前景：西方展望 Further restrictions in the regulatory environment 環(huán)境法規(guī)更加嚴(yán)格 Continued need for safer, more effective products 持續(xù)需要更安全，更有效的產(chǎn)品 Increased accessibility to usef

32、ul triggered systems for targeted delivery 利用有用的觸發(fā)機(jī)制，增強(qiáng)（藥物）達(dá)到目標(biāo)受體能力 Improved adjuvants offer reduced application rates 改善助劑以降低施用量 Increased role of polymeric systems to deliver better controlled release systems (including nanotechnologies) 增加聚合系統(tǒng)的作用，更好地控制釋放系統(tǒng)（包括納米技術(shù)，10-9） Greater understanding of crystallisation processes 更好地了解結(jié)晶過(guò)程 Changing pesticide chemistries will provide continually changing challenges to the formulator不斷變化的農(nóng)藥化學(xué)將會(huì)對(duì)制劑開(kāi)發(fā)人員帶來(lái)持續(xù)的挑戰(zhàn)Formulation Research : Future 制劑研究：未來(lái)1990s?2010s20