神經(jīng)內(nèi)分泌學(xué)生長軸課件

1、神經(jīng)內(nèi)分泌學(xué)生長軸神經(jīng)內(nèi)分泌學(xué)生長軸神經(jīng)內(nèi)分泌學(xué)生長軸人有了知識(shí)，就會(huì)具備各種分析能力，明辨是非的能力。神經(jīng)內(nèi)分泌學(xué)生長軸神經(jīng)內(nèi)分泌學(xué)生長軸神經(jīng)內(nèi)分泌學(xué)生長軸人有了神經(jīng)內(nèi)分泌學(xué)生長軸課件Growth hormone(GH):Secrete by anterior pituitary Single peptide chainComposed of 191 aamolecular mass: 22kDaGrowth hormone(GH):Secrete byFunction of Growth hormoneFurther growthSynthesize proteinDecompose fa

2、tGenerate sugarFunction of Growth hormoneFurtGH: Somatotrophin, Growth hormone is regulated by GHRH, SS (SRIH), and hypothalamic peptides as well as complex neuroendocrine network. 神經(jīng)內(nèi)分泌學(xué)生長軸課件1). GHRH and SS regulation of GH releaseGrowth hormone releasing hormone （GHRH）44 peptide distribution in AR

3、C , PVN , AMH, and VMH GH releaseGH DNAmRNA GH cell in pituitary proliferate and differentiate 1). GHRH and SS regulation GHRHvia：GHRH to anterior pituitary to bind its receptor (GHRH receptor) activate G-protein induce cAMP-PKA stimulate GH release.GHRH receptor: 7 transmembrane (see Fig.4) GHRHvia

4、：神經(jīng)內(nèi)分泌學(xué)生長軸課件GHRH receptor: 7 transmembrane GHRH receptor: 7 transmembrane生長抑素 SSvia： SS release from ME to anterior pituitary SS release into CSF via cell line ventricle(室管膜細(xì)胞) to anterior pituitary to inhibites GH release and synthesis。SS intermitted inhibit GH release，induce GH to lowest amplitude

5、生長抑素 SSvia：SS: SS-28, SS-14（2 activity type） SS receptor: SStr 1-5, SSrt-14, SSrt-28, 7-transmembrane domain, G-protein coupledSS: SS receptor subtypesSS receptor subtypesThe regulation of GH release by GHRH and SSThe regulation of GH release b2). Feedback mechanismGHRH regulates GH release by super

6、short loop：via stimulates SS release from CNS to to portal vessles SS via ultrashort negative feedback to regulating SS release GH ultrashort loop feedback ： stimulates SS release and reduces GHRH release2). Feedback mechanismGHRH reHypothalamus network for GH Hypothalamus network for GH 3).NTs regu

7、lates GH release1、Dopamine（DA）DA enhanced GH releaseMechanism stimulates GHRH release inhibites SS release3).NTs regulates GH release1、D2、Norepinephrine（NE）receptor: stimulation, majorreceptor: inhibition2、Norepinephrine（NE）3、5-HTStimulate GH release3、5-HT4、Acetylcholine（Ach） stimulation for GH rele

8、aseBy M receptorMechanism: inhibites SS release，but do not stimulates GHRH release4、Acetylcholine（Ach）5、Gamma-aminobutyric acid（GABA）Stimulation for GH release5、Gamma-aminobutyric acid（GABA6、Histamine（His）For GH release (inhibition and stimulation)6、Histamine（His）1、Stimulation (major)M-ENK-EPNTP 物質(zhì)VIP胃泌素 PACAP Galanin 4). Neuropeptides regulates GH1、Stimulation (major)4). Neuro2、inhibition (major)CRFCCKAIINPY2、inhibition (major)GC T3,T4 E and T 5). Hormone regulates GHGC 5). Hormone regulates GH6).The ot