Lycorine-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemELycorineCat. No.: HY-N0288CAS No.: 476-28-8分式: CHNO分量: 287.31作靶點(diǎn): Apoptosis作通路: Apoptosis儲(chǔ)存式: Please store the product under the recommended conditions inthe COA.溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 25 mg/mL (87.01 mM; Need ultrasonic)Mass Solvent1

2、 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 3.4806 mL 17.4028 mL 34.8056 mL5 mM 0.6961 mL 3.4806 mL 6.9611 mL10 mM 0.3481 mL 1.7403 mL 3.4806 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Lycorine從眼科植物科中提取的天然物堿，具有抗病毒，抗瘧疾和抗發(fā)炎的活性。Lycorine 抑制激素難治性抗前列腺癌 (PCa) 的長和轉(zhuǎn)移并誘導(dǎo)細(xì)胞凋亡 (apoptosis)。體外

3、研究 Lycorine inhibits cell proliferation in a dose-dependent manner in the abovementioned 4 PCa cell lines, andthe IC50 ranged from 5 M to 10 M., it also shows Lycorine has little effects on PNT1A cells proliferation1.REFERENCES1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE1. Hu M, et al.Lycorine is a novel inhibitor of the growth and metastasis of hormone-refractory prostate cancer.Oncotarget. 2015 Jun20;6(17):15348-61.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: 021-53700