L-Aspartic-acid-DataSheet-生命科學試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEL-Aspartic acidCat. No.: HY-N0666CAS No.: 56-84-8分式: CHNO分量: 133.1作靶點: Endogenous Metabolite作通路: Metabolic Enzyme/Protease儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 H2O : 8.33 mg/mL (62.58 mM

2、; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 7.5131 mL 37.5657 mL 75.1315 mL5 mM 1.5026 mL 7.5131 mL 15.0263 mL10 mM 0.7513 mL 3.7566 mL 7.5131 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 L-Aspartic acid種氨酸，被證明種結腸特異性藥物輸送的前體藥物。IC50 & Target Human Endog

3、enous Metabolite體內(nèi)研究L-Aspartic acid is shown to be a suitable prodrug for colon-specific drug deliverly 1. L-3HAsp remaining inthe brain at 5 min is increased by 206 and 178% by preadministration of 100 mM L-Aspartic acid and 100mM L-Glu, respectively, whereas 100 mM D-Asp does not affect L-3HAsp ef

4、flux transport. That value for L-1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE3HGlu at 20 min is increased by 145 and 156% by coadministration with 100 mM L-Aspartic acid and 100mM L-Glu, respectively, but not by D-Asp. It is interesting that the apparent efflux rate of L-Aspartic acidacross the

5、 BBB is sevenfold faster than that of L-Glu 2.REFERENCES1. Leopold CS, et al. In vivo pharmacokinetic study for the assessment of poly(L-aspartic acid) as a drug carrier for colon-specific drugdelivery. J Pharmacokinet Biopharm. 1995 Aug;23(4):397-406.2. Hosoya K, et al. Blood-brain barrier produces significant efflux of L-aspartic acid but not D-aspartic acid: in vivo evidence using the brainefflux index method. J Neurochem. 1999 Sep;73(3):1206-11.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3