Torcetrapib-CP-529414-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemETorcetrapibCat. No.: HY-12089CAS No.: 262352-17-0Synonyms: CP-529414分式: CHFNO分量: 600.47作靶點: CETP作通路: Metabolic Enzyme/Protease儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 100 mg/mL (166.

2、54 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 1.6654 mL 8.3268 mL 16.6536 mL5 mM 0.3331 mL 1.6654 mL 3.3307 mL10 mM 0.1665 mL 0.8327 mL 1.6654 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實驗 請根據(jù)您的實驗動物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前請先配制澄的儲備液，再依次添加助溶?為保證實驗結(jié)果的可靠性

3、，體內(nèi)實驗的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄的儲備液可以根據(jù)儲存條件，適當(dāng)保存；以下溶劑前的百分指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (4.16 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (4.16 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGIC

4、AL ACTIVITY物活性 Torcetrapib(CP-529414)CETP效抑制劑，IC50值為37nM。REFERENCES1. Clark RW, et al. Raising high-density lipoprotein in humans through inhibition of cholesteryl ester transfer protein: an initial multidosestudy of torcetrapib. Arterioscler Thromb Vasc Biol. 2004 Mar;24(3):490-7.2. Hu X, et al. To

5、rcetrapib induces aldosterone and cortisol production by an intracellular calcium-mediated mechanism independently ofcholesteryl ester transfer protein inhibition. Endocrinology. 2009 May;150(5):2211-9.3. Barter PJ, et al. Effects of torcetrapib in patients at high risk for coronary events. N Engl J

6、 Med. 2007 Nov 22;357(21):2109-22.4. Morehouse LA, et al. Inhibition of CETP activity by torcetrapib reduces susceptibility to diet-induced atherosclerosis in New ZealandWhite rabbits. J Lipid Res. 2007 Jun;48(6):1263-72.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-82