Salvianolic-acid-A - MMP - 生命科學試劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemESalvianolic acid ACat. No.: HY-N0318CAS No.: 96574-01-5分式: CHO分量: 494.45作靶點: MMP作通路: Metabolic Enzyme/Protease儲存式: 4C, protect from light* In solvent : -80C, 6 months; -20C, 1 month (protect fromlight)溶解性數(shù)據(jù)體外實驗 DMSO : 125 mg/mL

2、(252.81 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.0224 mL 10.1122 mL 20.2245 mL5 mM 0.4045 mL 2.0224 mL 4.0449 mL10 mM 0.2022 mL 1.0112 mL 2.0224 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內實驗 請根據(jù)您的實驗動物和給藥式選擇適當?shù)娜芙獍福渲魄罢埾扰渲瞥吻宓膬湟?，再依次添加助溶?為保證實驗結果的可靠性，體內實驗的作液，建議您現(xiàn)現(xiàn)配，

3、當天使；澄清的儲備液可以根據(jù)儲存條件，適當保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.17 mg/mL (4.39 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.17 mg/mL (4.39 mM); Clear solutionBIOLOGICAL ACTIVITY1/2 Master of Small Molecules

4、 您邊的抑制劑師www.MedChemE物活性 Salvianolic acid A 可通過抑制質屬鈦酶 9 (MMP-9) 和抗炎作來保護腦屏障。IC50 & Target MMP-9體內研究 A significant beneficial effect of Salvianolic acid A (SAA) is observed in the Salvianolic acid A treatmentgroups. Salvianolic acid A (20 mg/kg) could significantly prolonged the retention time of rats

5、on the plate. Whilecompared with sham operation group, the brain water content in model group significantly increases, which isattenuated significantly by Salvianolic acid A (10 and 20 mg/kg). Compared with the model group, Salvianolicacid A (5, 10, and 20 mg/kg) could maintain the normal structures

6、 of neurons and increase neurons number. Itis also found that Salvianolic acid A (20 mg/kg) could significantly reduce I/R induced MMP-9 upregulation.While the MMP-2 expression is not significantly affected by Salvianolic acid A. Tissue inhibitors ofmetalloproteinases (TIMPs) could inhibit the activ

7、ity of MMPs through high affinity binding to MMPs catalyticdomain 1.REFERENCES1. Zhang W, et al. Salvianolic acid A attenuates ischemia reperfusion induced rat brain damage by protecting the blood brain barrierthrough MMP-9 inhibition and anti-inflammation. Chin J Nat Med. 2018 Mar;16(3):184-193.McePdfHeightCaution: Product has not been fully validated for medical applications.For research u