LPA2-antagonist-1 - LPL Receptor 抑制劑 - 生命科學(xué)試劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemELPA2 antagonist 1Cat. No.: HY-18075CAS No.: 1017606-66-4分式: CHClNOS分量: 500.46作靶點(diǎn): LPL Receptor作通路: GPCR/G Protein儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMF : 100 mg/mL (199.82 mM)DMSO : 1

2、00 mg/mL (199.82 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 1.9982 mL 9.9908 mL 19.9816 mL5 mM 0.3996 mL 1.9982 mL 3.9963 mL10 mM 0.1998 mL 0.9991 mL 1.9982 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn) 請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍福渲魄罢?qǐng)先配制澄的儲(chǔ)備液，再依次添加助

3、溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (5.00 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (5.00 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制

4、劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 LPA2 antagonist 1LPA2的拮抗劑，IC50值為17 nM。IC50 & Target IC50: 17 nM (LPA2) 1體外研究 LPA2 antagonist 1 inhibits the phosphorylation of Erk induced by LPA in a concentration dependent manner.LPA2 antagonist 1 inhibits HCT-116 colon cancer cell proliferation caused by LPA

5、in a doses dependentmanner 1.REFERENCES1. Beck HP, et al. Discovery of potent LPA2 (EDG4) antagonists as potential anticancer agents. Bioorg Med Chem Lett. 2008 Feb1;18(3):1037-41.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-58955