Ingenol-minus-Ingenol-DataSheet-生命科學試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEIngenolCat. No.: HY-N0865CAS No.: 30220-46-3Synonyms: (-)-Ingenol分式: CHO分量: 348.43作靶點: PKC作通路: Epigenetics; TGF-beta/Smad儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 100 mg/mL (287.00 mM

2、; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.8700 mL 14.3501 mL 28.7002 mL5 mM 0.5740 mL 2.8700 mL 5.7400 mL10 mM 0.2870 mL 1.4350 mL 2.8700 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實驗請根據(jù)您的實驗動物和給藥式選擇適當?shù)娜芙獍?，配制前請先配制澄的儲備液，再依次添加助溶?為保證實驗結(jié)果的可靠性，體內(nèi)實驗的作液，建議您現(xiàn)現(xiàn)配，當天使；澄的儲備液可以根

3、據(jù)儲存條件，適當保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (7.18 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (7.18 mM); Clear solution3. 請依序添加每種溶劑： 10% DMSO 90% corn oil1/2 Master of Small Molecule

4、s 您邊的抑制劑師www.MedChemESolubility: 2.5 mg/mL (7.18 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Ingenol種 PKC 激活劑，Ki 值為 30 M，具有抗腫瘤活性。IC50 & Target PKC30 M (Ki)體外研究 Ingenol is a PKC activator, with a Ki of 30 M. Ingenol induces ornithine decarboxylase activity (1, 3 mM),and causes morphological changes (1

5、mM) in primary mouse epidermal keratinocytes. Ingenol (125 M, 250M, 500 M, 1 mM) also inhibits cell-cell communication 1.REFERENCES1. Hasler CM, et al. Specific binding to protein kinase C by ingenol and its induction of biological responses. Cancer Res. 1992 Jan1;52(1):202-8.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-