Caerulomycin-A-Cerulomycin-DataSheet-生命科學試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemECaerulomycin ACat. No.: HY-114495CAS No.: 21802-37-9Synonyms: Cerulomycin; Caerulomycin分式: CHNO分量: 229.23作靶點: Fungal作通路: Anti-infection儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 150 mg

2、/mL (654.36 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 4.3624 mL 21.8122 mL 43.6243 mL5 mM 0.8725 mL 4.3624 mL 8.7249 mL10 mM 0.4362 mL 2.1812 mL 4.3624 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實驗 請根據(jù)您的實驗動物和給藥式選擇適當?shù)娜芙獍?，配制前請先配制澄清的儲備液，再依次添加助溶?為保證實驗結(jié)果的可靠性，體內(nèi)實驗的作液，建議您

3、現(xiàn)現(xiàn)配，當天使；澄清的儲備液可以根據(jù)儲存條件，適當保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (10.91 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (10.91 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.Med

4、ChemEBIOLOGICAL ACTIVITY物活性 Caerulomycin A (Cerulomycin; Caerulomycin)種抗真 (antifungal) 化合物，能夠誘導 T 細胞的產(chǎn)。Caerulomycin A 能夠抑制 IFN- 誘導的 STAT1 通路，從增強 TGF-Smad3 信號通路。具有抗真菌和抗細活性，可于免疫病的研究 1。IC50 & Target Antifungal 1TGF-Smad3 1REFERENCES1. Gurram RK, et al. Caerulomycin A enhances transforming growth factor

5、- (TGF-)-Smad3 protein signaling by suppressing interferon-(IFN-)-signal transducer and activator of transcription 1 (STAT1) protein signaling to expand regulatory T cells (Tregs). J Biol Chem. 2014Jun 20;289(25):17515-28.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-589