Fluvastatin-sodium-XU-62320-sodium-DataSheet-生命科學試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEFluvastatin sodiumCat. No.: HY-14664ACAS No.: 93957-55-2Synonyms: XU 62320 sodium分式: CHFNNaO+分量: 434.46作靶點: HMG-CoA Reductase (HMGCR); Autophagy作通路: Metabolic Enzyme/Protease; Autophagy儲存式: Powder -20C 3 years4C 2 yearsIn solven

2、t -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 H2O : 50 mg/mL (115.09 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.3017 mL 11.5085 mL 23.0171 mL5 mM 0.4603 mL 2.3017 mL 4.6034 mL10 mM 0.2302 mL 1.1509 mL 2.3017 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Fl

3、uvastatin sodium (XU 62320 sodium)是HMG-CoA還原酶競爭性抑制劑。IC50 & Target HMGCR 1.體外研究Fluvastatin (XU 62320) is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR),the enzyme that catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol1/2 Master

4、 of Small Molecules 您邊的抑制劑師www.MedChemEbiosynthesis. Human hepatocellular carcinoma cell (HCC) studies indicate that Fluvastatin (XU 62320)induces G2/M phase arrest. In the presence of Fluvastatin (XU 62320), HCC cells show a decrease of Bcl-2and procaspase-9 expression, and an increase in Bax, clea

5、ved caspase-3, and cytochrome c. Fluvastatin(XU 62320) is antilipemic and is used to reduce plasma cholesterol levels and prevent cardiovasculardisease.戶使本產(chǎn)品發(fā)表的科研獻 Mol Med Rep. 2018 Mar;17(3):3944-3950.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Arajo FA, Rocha MA, Capettin

6、i LS, et al. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (fluvastatin) decreasesinflammatory angiogenesis in mice. APMIS. 2012 24. Epub ahead of print2. Makabe S, Takahashi Y, Watanabe H, et al. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2

7、-dependent antioxidant pathway. Atherosclerosis. 2010 Dec;213(2):377-84.3. Zhang W, Wu J, Zhou L, et al. Fluvastatin, a lipophilic statin, induces apoptosis in human hepatocellular carcinoma cells throughmitochondria-operated pathway. Indian J Exp Biol. 2010 Dec;48(12):1167-74.4. Scripture CD, Pieper JA. Clinical pharmacokinetics of fluvastatin. Clin Pharmacokinet. 2001;40(4):263-81.McePdfHeightCaution: Product has not been fully validated for medical applications.For resear