8-Bromo-cAMP-sodium-salt-8-Br-Camp-sodium-salt-DataSheet-生命科學試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemE8-Bromo-cAMP sodium saltCat. No.: HY-12306CAS No.: 76939-46-3Synonyms: 8-Br-Camp sodium salt分式: CHBrNNaOP分量: 430.08作靶點: PKA作通路: Protein Tyrosine Kinase/RTK; Stem Cell/Wnt儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months

2、-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 125 mg/mL (290.64 mM; Need ultrasonic)H2O : 33.33 mg/mL (77.50 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.3251 mL 11.6257 mL 23.2515 mL5 mM 0.4650 mL 2.3251 mL 4.6503 mL10 mM 0.2325 mL 1.1626 mL 2.3251 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解

3、度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實驗請根據(jù)您的實驗動物和給藥式選擇適當?shù)娜芙獍?，配制前請先配制澄清的儲備液，再依次添加助溶?為保證實驗結(jié)果的可靠性，體內(nèi)實驗的作液，建議您現(xiàn)現(xiàn)配，當天使；澄清的儲備液可以根據(jù)儲存條件，適當保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (4.84 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD

4、in saline)1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemESolubility: 2.08 mg/mL (4.84 mM); Clear solution3. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (4.84 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 8-Bromo-cAMP sodium salt (8-Br-Camp sodium salt)種環(huán) AMP 類似物， 種環(huán) AMP 依賴性蛋激酶(PKA) 激活劑 1。IC

5、50 & Target PKA 1體外研究 8-Bromo-cAMP sodium salt is a brominated derivative of cyclic AMP. 8-Bromo-cAMP sodium salt enhancesthe efficiency of cellular reprogramming. 8-Bromo-cAMP sodium salt improves the reprogramming efficiencyof human neonatal foreskin fibroblast (HFF1) cells. 8-Bromo-cAMP sodium sa

6、lt inhibits proliferation, inducedifferentiation and apoptosis in a malignant glioma cell line (A-172) and an esophageal cancer cell line (Eca-109) 1.REFERENCES1. Wang Y, et al. A cyclic AMP analog, 8-Br-cAMP, enhances the induction of pluripotency in human fibroblast cells. Stem Cell Rev. 2011Jun;7(2):331-41.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 4