Acetoacetic-acid-sodium-salt-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEAcetoacetic acid sodium saltCat. No.: HY-112540BCAS No.: 623-58-5分式: CHNaO分量: 124.07作靶點: Others作通路: Others儲存式: -20C, stored under nitrogen* In solvent : -80C, 6 months; -20C, 1 month (stored undernitrogen)溶解性數(shù)據(jù)體外實驗 H2O : 50 mg/m

2、L (403.00 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 8.0600 mL 40.2998 mL 80.5997 mL5 mM 1.6120 mL 8.0600 mL 16.1199 mL10 mM 0.8060 mL 4.0300 mL 8.0600 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Acetoacetic acid sodium salt種酯化脂 酸代謝物，參與類糖尿病的發(fā)展。Ace

3、toacetic acid sodiumsalt 誘導(dǎo)氧化應(yīng)激，抑制肝細胞中極低密度脂蛋的組裝 1。體外研究Acetoacetic acid sodium salt induces oxidative stress to inhibit the assembly of very low density lipoprotein inbovine hepatocytes 1.Acetoacetic acid (0.6, 2.4, 4.8 mM) increases malondialdehyde (MDA) content in high-dose group (GH)group, decreas

4、es mRNA expression of Mn SOD, Cu/Zn SOD, and glutathione peroxidase (GSH-Px) in allgroups, lowers catalase (CAT) mRNA expression in medial-dose group (GM), and GH groups. In addition,1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEAcetoacetic acid down-regulates the mRNA expression of apolipoprotei

5、n B100 (ApoB100), apolipoprotein E(ApoE), and low density lipoprotein receptor (LDLR). Thus, VLDL assembly is decreased andtriglyceride (TG)accumulation is increased in these bovine hepatocytes 1.REFERENCES1. Shi X, et al. Acetoacetic acid induces oxidative stress to inhibit the assembly of very low density lipoprotein in bovine hepatocytes. JDairy Res. 2016 Nov;83(4):442-446.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;