Tyrphostin-A9-AG-17-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemETyrphostin A9Cat. No.: HY-15511CAS No.: 10537-47-0Synonyms: AG 17; Tyrphostin 9分式: CHNO分量: 282.38作靶點(diǎn): VEGFR作通路: Protein Tyrosine Kinase/RTK儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 10

2、0 mg/mL (354.13 mM)H2O : 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (8.85 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 Tyrphostin A9(AG 17)是51種酪氨酸激酶抑制劑，是線粒體分裂誘導(dǎo)劑。REFERENCES1. Park SJ, Park YJ, Shin JH, et al. A receptor tyrosine kinase inhibi

3、tor, Tyrphostin A9 induces cancer cell death through Drp1 dependentmitochondria fragmentation. Biochem Biophys Res Commun. 2011 May 13;408(3):465-70.2. Richard F. Loeser, Christopher B. Forsyth, Allen M. Samarel et al. Fibronectin Fragment Activation of Proline-rich Tyrosine Kinase PYK2Mediates Inte

4、grin Signals Regulating Collagenase-3 Expression by Human Chondrocytes through a Protein Kinase C-dependent Pathway.The Journal of Biological Chemistry, 2003, 278, 24577-24585.3. Michele Fuortes, Maxine Melchior, Hyunsil Han, et al. Role of the tyrosine kinase pyk2 in the integrin-dependent activati

5、on of humanneutrophils by TNF. J Clin Invest. 1999;104(3):327-335.4. Johan Thyberg . Tyrphostin A9 and wortmannin perturb the Golgi complex and block proliferation of vascular smooth muscle cells.European Journal of Cell Biology.1998,76(1): 33-425. R Marhaba, F Mary, C Pelassy, et al. Tyrphostin A9 inhibits calcium release-dependent phosphorylations and calcium entry via calciumrelease-activated channel in Jurkat T cells. The Journal of Immunology. 1996,157 (4): 1468-1473McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-